Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GFAP_HUMAN
Description:glial fibrillary acidic protein [Source:HGNC Symbol;Acc:4235]
Location:chr17 q21.31
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S13SAARRsYVSSGROCK_groupphosphoELM; RegPhos
T150AQDLAtVRQKLMyosin_tail_1; Filament; PhosphoSitePlus
S38PGTRLsLARMPPKC_groupphosphoELM; RegPhos
Y366IEIATyRKLLEFilamentPhosphoSitePlus
T7ERRRItSAARRAurB(Aurora BRegPhos
T7AARRROCK_groupphosphoELM
Y324REAASyQEALAFilament; Myosin_tail_1; PhosphoSitePlus
Y172NNLAAyRQEADMyosin_tail_1; Filament; PhosphoSitePlus
T7AARRAurora BphosphoELM
S8RRRITsAARRSCDC2(CDK1RegPhos
S17RSYVSsGEMMVCaMK2_groupRegPhos
T7AARRphosphoELM
S13SAARRsYVSSGAurB(Aurora BRegPhos
S8RRRITsAARRSCDK1HPRD
S8RRRITsAARRSphosphoELM
Y116KLADVyQAELRMyosin_tail_1; Filament; PhosphoSitePlus
S38PGTRLsLARMPROCK_groupphosphoELM; RegPhos
S38PGTRLsLARMPCAMK2AHPRD
Y14AARRSyVSSGEFilament_headPhosphoSitePlus
T383TIPVQtFSNLQRegPhos
S38PGTRLsLARMPAurB(Aurora BRegPhos
S13SAARRsYVSSGAurora BphosphoELM
S17RSYVSsGEMMVFilament_headPhosphoSitePlus
S38PGTRLsLARMPCaM-KII_groupphosphoELM
T240LKEIRtQYEAMFilament; Myosin_tail_1; PhosphoSitePlus
S38PGTRLsLARMPPKACaRegPhos
S38PGTRLsLARMPPRKACAHPRD
S38PGTRLsLARMPROCK1HPRD; phosphoELM; RegPhos
S13SAARRsYVSSGPRKACAHPRD
T7ERRRItSAARRROCK_groupRegPhos
S8RRRITsAARRSCDC2RegPhos
T7AARRROCK1HPRD; phosphoELM
S393QIRETsLDTKSCaMK2aRegPhos
T131RLDQLtANSARMyosin_tail_1; Filament; PhosphoSitePlus
S393QIRETsLDTKSCAMK2AHPRD
S305RGTNEsLERQMFilament; Myosin_tail_1; PhosphoSitePlus
S17RSYVSsGEMMVROCK1HPRD; RegPhos
S17RSYVSsGEMMVROCK_groupRegPhos
S17RSYVSsGEMMVCaMK2aRegPhos
S17RSYVSsGEMMVPKACaRegPhos
S17RSYVSsGEMMVPKCaRegPhos
S13SAARRsYVSSGCaMK2_groupRegPhos
S13SAARRsYVSSGCaMK2aRegPhos
S8RRRITsAARRSFilament_headPhosphoSitePlus
S13SAARRsYVSSGCAMK2AHPRD
S17RSYVSsGEMMVCAMK2AHPRD
S38PGTRLsLARMPCaMK2aRegPhos
S38PGTRLsLARMPPRKCAHPRD
S17RSYVSsGEMMVPRKACAHPRD
S38PGTRLsLARMPphosphoELM
T110RAKEPtKLADVRegPhos
S13SAARRsYVSSGPKACaRegPhos
S17RSYVSsGEMMVCaM-KII_groupphosphoELM
Y242EIRTQyEAMASFilament; Myosin_tail_1; PhosphoSitePlus
S13SAARRsYVSSGCaM-KII_groupphosphoELM
T7ERRRItSAARRFilament_headPhosphoSitePlus
S38PGTRLsLARMPFilament_headPhosphoSitePlus
S38PGTRLsLARMPPKCaRegPhos
S13SAARRsYVSSGFilament_headPhosphoSitePlus
T7ERRRItSAARRROCK1RegPhos
S13SAARRsYVSSGphosphoELM
S13SAARRsYVSSGROCK1HPRD; phosphoELM; RegPhos
S13SAARRsYVSSGPKCaRegPhos
S38PGTRLsLARMPAurora BphosphoELM
S17RSYVSsGEMMVPKC_groupphosphoELM; RegPhos
S17RSYVSsGEMMVphosphoELM
S13SAARRsYVSSGPRKCAHPRD
S38PGTRLsLARMPCaMK2_groupRegPhos
S13SAARRsYVSSGPKC_groupphosphoELM; RegPhos
Y349RHLQEyQDLLNFilament; Myosin_tail_1PhosphoSitePlus
S17RSYVSsGEMMVPRKCAHPRD

Dephosphorylation site
GFAP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253408E205KCOSMICPancreatic Cancer
ENSP00000253408R136QCOSMICHepatocellular Carcinoma21822264
ENSP00000253408D430NCOSMICSkin Cancer21984974

Differential expressed protein
GFAP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S13Filament_headITSAARRsYVSSGEMFTLD20886841PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
AURKB_HUMANGFAP_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANGFAP_HUMANkinase -> substrateHPRD
CDK1_HUMANGFAP_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANGFAP_HUMANkinase -> substrateRegPhos
KCC4_HUMANGFAP_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANGFAP_HUMANkinase -> substrateHPRD
ROCK1_HUMANGFAP_HUMANkinase -> substrateRegPhos
SP1_HUMANGFAP_HUMANTF -> target geneTRANSFAC
AP2A_HUMANGFAP_HUMANTF -> target geneTRANSFAC
NFIC_HUMANGFAP_HUMANTF -> target geneTRANSFAC
TBP_HUMANGFAP_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GFAP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042995cell projectionIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0060252positive regulation of glial cell proliferationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0045103intermediate filament-based processIEAbiological_process
GO:0060020Bergmann glial cell differentiationIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0031102neuron projection regenerationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0010625positive regulation of Schwann cell proliferationIEAbiological_process
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0044464cell partIEAcellular_component
GO:0005882intermediate filamentIEAcellular_component
GO:0014002astrocyte developmentIEAbiological_process
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0044297cell bodyIEAcellular_component
GO:0045109intermediate filament organizationIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0019900kinase bindingIEAmolecular_function
GO:0005198structural molecule activityIEAmolecular_function
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0051580regulation of neurotransmitter uptakeIEAbiological_process