Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDK7_HUMAN
Description:cyclin-dependent kinase 7 [Source:HGNC Symbol;Acc:1778]
Location:chr5 q13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S164AKSFGsPNRAYCDC2(CDK1RegPhos; SysPTM
S7AKRYHPRD; SysPTM
T316NCPVEtLKEQSHPRD
S164AKSFGsPNRAYphosphoELM; RegPhos; SysPTM
T170PNRAYtHQVVTCDC2RegPhos; SysPTM
S161FGLAKsFGSPNHPRD; phosphoELM
T170PNRAYtHQVVTHPRD; phosphoELM; RegPhos; SysPTM
Y169SPNRAyTHQVVHPRD
S7ALDVKsRAKRYPhosphoSitePlus; SysPTM
T170PNRAYtHQVVTCDK2HPRD; phosphoELM; RegPhos; SysPTM
T170PNRAYtHQVVTCDK1HPRD; SysPTM
T170PNRAYtHQVVTCDK7phosphoELM; RegPhos; SysPTM
T287ARITAtQALKMPkinasePhosphoSitePlus; SysPTM
T170PNRAYtHQVVTCDC2(CDK1RegPhos; SysPTM
S164AKSFGsPNRAYCDK1HPRD; SysPTM
S164AKSFGsPNRAYCDK2HPRD; phosphoELM; RegPhos; SysPTM
S164AKSFGsPNRAYCDK7phosphoELM; RegPhos; SysPTM
S161FGLAKsFGSPNPkinasePhosphoSitePlus
S321TLKEQsNPALAPhosphoSitePlus; HPRD; SysPTM
T170PNRAYtHQVVTPkinasePhosphoSitePlus; SysPTM
S164AKSFGsPNRAYPkinasePhosphoSitePlus; SysPTM
S164AKSFGsPNRAYCDC2RegPhos; SysPTM
T25EGQFAtVYKARHPRD
T287ARITAtQALKMHPRD; SysPTM

Dephosphorylation site
CDK7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256443*347CCOSMICOvarian Cancer21720365
ENSP00000256443M240ICOSMICGastric Cancer21097718
ENSP00000256443I43LCOSMICMelanoma21499247
ENSP00000256443*347SCOSMICOvarian Cancer21720365
ENSP00000256443E99QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000256443T25SCOSMICOvarian Cancer20668451

Differential expressed protein
CDK7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDK7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCDK7_HUMANkinase -> substrateRegPhos
CDK7_HUMANHDAC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNCBP2_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSOSB2_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANICK_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANMAD1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNOL7_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANLASP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CDK7_HUMANHSFY1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCDK2_HUMANkinase -> substrateHPRD; RegPhos; NetPath
CDK7_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPO2F1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANSET_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANZCHC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK2_HUMANCDK7_HUMANkinase -> substrateRegPhos
CDK7_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANP53_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCDK7_HUMANkinase -> substrateRegPhos
CDK7_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANCDK7_HUMANkinase -> substrateRegPhos
CDK7_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANESR1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CDK7_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCNOT6_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPCGF6_HUMANkinase -> substrateHPRD; RegPhos
CDK7_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANHES1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMAN2AAB_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANORC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANRARA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANHIRP3_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANRNH2C_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCDK4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANCDK1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CDK7_HUMANCRY1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANE2F1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK7_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa03420Nucleotide excision repair
hsa03022Basal transcription factors

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007050cell cycle arrestTASbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0003713transcription coactivator activityNASmolecular_function
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIDAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0006362transcription elongation from RNA polymerase I proTASbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005675holo TFIIH complexIDAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function