Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UBA1_HUMAN
Description:ubiquitin-like modifier activating enzyme 1 [Source:HGNC Symbol;Acc:12469]
Location:chrX p11.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T800QVPEFtPKSGVUBACTPhosphoSitePlus
S4MSSSPlSKKCDC2RegPhos
Y388IRKLAyVAAGDPhosphoSitePlus
T832EELKAtLPSPDHPRD; phosphoELM
S4__MSSsPLSKKPhosphoSitePlus
S21DPKPGsNCSPAPhosphoSitePlus; HPRD; phosphoELM
S13KKRRVsGPDPKPhosphoSitePlus; HPRD; phosphoELM
S529VTKLKsDTAAAHPRD
S816DQELQsANASVPhosphoSitePlus; HPRD
T603SGTLGtKGNVQThiFPhosphoSitePlus
S835KATLPsPDKLPCDC2RegPhos
S13KKRRVsGPDPKCK2_groupphosphoELM; RegPhos
Y55IDEGLySRQLYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S35LSEVPsVPTNGHPRD
Y60YSRQLyVLGHEPhosphoSitePlus
T800QVPEFtPKSGVHPRD; phosphoELM
Y560DTERIyDDDFFThiFPhosphoSitePlus
S835KATLPsPDKLPPhosphoSitePlus; phosphoELM
S810VKIHVsDQELQUBACTPhosphoSitePlus
T191LVVADtRGLFGThiFPhosphoSitePlus
Y273KVLGPyTFSICPhosphoSitePlus
T274VLGPYtFSICDPhosphoSitePlus
S835KATLPsPDKLPCDK1HPRD; phosphoELM
S4MSSSPlSKKCDC2(CDK1RegPhos
S309KSLVAsLAEPDPhosphoSitePlus; HPRD
S4LSKKCDK1HPRD; phosphoELM
S56DEGLYsRQLYVPhosphoSitePlus
T38VPSVPtNGMAKHPRD
T682LRLAGtQPLEVPhosphoSitePlus
S293RGGIVsQVKVPPhosphoSitePlus
T318PDFVVtDFAKFPhosphoSitePlus; HPRD
S284DTSNFsDYIRGPhosphoSitePlus
S781YGLTGsQDRAAUBACTPhosphoSitePlus
Y873LRAENyDIPSAUBACTPhosphoSitePlus
S46MAKNGsEADIDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S24PGSNCsPAQSVPhosphoSitePlus; HPRD; phosphoELM
S835KATLPsPDKLPCDC2(CDK1RegPhos
S820QSANAsVDDSRPhosphoSitePlus; HPRD
S305KISFKsLVASLPhosphoSitePlus; HPRD
S140LAELNsYVPVTThiFPhosphoSitePlus
Y590DRRCVyYRKPLThiFPhosphoSitePlus
Y286SNFSDyIRGGIPhosphoSitePlus
S866FIVAAsNLRAEUBACTPhosphoSitePlus
S824ASVDDsRLEELPhosphoSitePlus
S810VKIHVsDQELQHPRD

Dephosphorylation site
UBA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000338413R675*BIOMARTBreast Cancer21930507, 21930502
ENSP00000338413R174fs*33COSMICOvarian Cancer21720365
ENSP00000338413S621CCOSMICLymphoma21995386
ENSP00000366568R675*BIOMARTBreast Cancer21930507, 21930502
ENSP00000366568R174fs*33COSMICOvarian Cancer21720365
ENSP00000366568S621CCOSMICLymphoma21995386

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000338413Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000338413Esophageal CancerNormal vs. CancertissueDown0.3119142970
ENSP00000338413Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.420804217
ENSP00000338413Breast CancerNormal vs. CancertissueUp6.120005186
ENSP00000338413Breast CancerNormal vs. CancertissueUp7.720005186
ENSP00000338413Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000338413Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000338413Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.520625496
ENSP00000338413Gastric CancerNormal vs. CancertissueDown0.4315761955

Hyperphosphorylation site
UBA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANUBA1_HUMANkinase -> substrateRegPhos
CDK1_HUMANUBA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05012Parkinson's disease
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0016567protein ubiquitinationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008219cell deathIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0008641small protein activating enzyme activityIEAmolecular_function
GO:0016874ligase activityIEAmolecular_function
GO:0006464cellular protein modification processIEAbiological_process


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