| UniProt/SwissProt ID: | UBA1_HUMAN |
| Description: | ubiquitin-like modifier activating enzyme 1 [Source:HGNC Symbol;Acc:12469] |
| Location: | chrX p11.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T800 | QVPEFtPKSGV | UBACT | PhosphoSitePlus |
| S4 | MSSSPlSKK | CDC2 | RegPhos |
| Y388 | IRKLAyVAAGD | PhosphoSitePlus | |
| T832 | EELKAtLPSPD | HPRD; phosphoELM | |
| S4 | __MSSsPLSKK | PhosphoSitePlus | |
| S21 | DPKPGsNCSPA | PhosphoSitePlus; HPRD; phosphoELM | |
| S13 | KKRRVsGPDPK | PhosphoSitePlus; HPRD; phosphoELM | |
| S529 | VTKLKsDTAAA | HPRD | |
| S816 | DQELQsANASV | PhosphoSitePlus; HPRD | |
| T603 | SGTLGtKGNVQ | ThiF | PhosphoSitePlus |
| S835 | KATLPsPDKLP | CDC2 | RegPhos |
| S13 | KKRRVsGPDPK | CK2_group | phosphoELM; RegPhos |
| Y55 | IDEGLySRQLY | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S35 | LSEVPsVPTNG | HPRD | |
| Y60 | YSRQLyVLGHE | PhosphoSitePlus | |
| T800 | QVPEFtPKSGV | HPRD; phosphoELM | |
| Y560 | DTERIyDDDFF | ThiF | PhosphoSitePlus |
| S835 | KATLPsPDKLP | PhosphoSitePlus; phosphoELM | |
| S810 | VKIHVsDQELQ | UBACT | PhosphoSitePlus |
| T191 | LVVADtRGLFG | ThiF | PhosphoSitePlus |
| Y273 | KVLGPyTFSIC | PhosphoSitePlus | |
| T274 | VLGPYtFSICD | PhosphoSitePlus | |
| S835 | KATLPsPDKLP | CDK1 | HPRD; phosphoELM |
| S4 | MSSSPlSKK | CDC2(CDK1 | RegPhos |
| S309 | KSLVAsLAEPD | PhosphoSitePlus; HPRD | |
| S4 | LSKK | CDK1 | HPRD; phosphoELM |
| S56 | DEGLYsRQLYV | PhosphoSitePlus | |
| T38 | VPSVPtNGMAK | HPRD | |
| T682 | LRLAGtQPLEV | PhosphoSitePlus | |
| S293 | RGGIVsQVKVP | PhosphoSitePlus | |
| T318 | PDFVVtDFAKF | PhosphoSitePlus; HPRD | |
| S284 | DTSNFsDYIRG | PhosphoSitePlus | |
| S781 | YGLTGsQDRAA | UBACT | PhosphoSitePlus |
| Y873 | LRAENyDIPSA | UBACT | PhosphoSitePlus |
| S46 | MAKNGsEADID | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S24 | PGSNCsPAQSV | PhosphoSitePlus; HPRD; phosphoELM | |
| S835 | KATLPsPDKLP | CDC2(CDK1 | RegPhos |
| S820 | QSANAsVDDSR | PhosphoSitePlus; HPRD | |
| S305 | KISFKsLVASL | PhosphoSitePlus; HPRD | |
| S140 | LAELNsYVPVT | ThiF | PhosphoSitePlus |
| Y590 | DRRCVyYRKPL | ThiF | PhosphoSitePlus |
| Y286 | SNFSDyIRGGI | PhosphoSitePlus | |
| S866 | FIVAAsNLRAE | UBACT | PhosphoSitePlus |
| S824 | ASVDDsRLEEL | PhosphoSitePlus | |
| S810 | VKIHVsDQELQ | HPRD | |
| Dephosphorylation site |
| UBA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338413 | R675* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000338413 | R174fs*33 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000338413 | S621C | COSMIC | Lymphoma | 21995386 | ENSP00000366568 | R675* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000366568 | R174fs*33 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000366568 | S621C | COSMIC | Lymphoma | 21995386 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000338413 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000338413 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.31 | 19142970 | ENSP00000338413 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.4 | 20804217 | ENSP00000338413 | Breast Cancer | Normal vs. Cancer | tissue | Up | 6.1 | 20005186 | ENSP00000338413 | Breast Cancer | Normal vs. Cancer | tissue | Up | 7.7 | 20005186 | ENSP00000338413 | Breast Cancer | Cancer vs. Cancer (Non-TNBC vs. TNBC) | cell line | Up | 20596302 | ENSP00000338413 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000338413 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.5 | 20625496 | ENSP00000338413 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.43 | 15761955 |
| Hyperphosphorylation site |
| UBA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | UBA1_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | UBA1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05012 | Parkinson's disease |
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0008641 | small protein activating enzyme activity | IEA | molecular_function |
| GO:0016874 | ligase activity | IEA | molecular_function |
| GO:0006464 | cellular protein modification process | IEA | biological_process |