Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLK1_HUMAN
Description:polo-like kinase 1 [Source:HGNC Symbol;Acc:9077]
Location:chr16 p12.2
Node attribute:substrate; kinase; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S461RDGTEsYLTVSHPRD; SysPTM
S224APEVLsKKGHSPkinasePhosphoSitePlus
S103MSMEIsIHRSLHPRD; SysPTM
S330FSIAPsSLDPSPhosphoSitePlus; HPRD
S450YNDGDsLQYIEHPRD; SysPTM
T210GERKKtLCGTPLOKphosphoELM; RegPhos; SysPTM
S103MSMEIsIHRSLPkinasePhosphoSitePlus; SysPTM
T6GKLAHPRD; SysPTM
T210GERKKtLCGTPPkinasePhosphoSitePlus; SysPTM
T464TESYLtVSSHPPOLO_boxPhosphoSitePlus; SysPTM
T6MSAAVtAGKLAPhosphoSitePlus; SysPTM
S387HSVNAsKPSERPhosphoSitePlus; HPRD; phosphoELM
S269KKNEYsIPKHIautocatalysis RegPhos
S2____MsAAVTAPhosphoSitePlus
S335SSLDPsNRKPLPhosphoSitePlus; RegPhos
T464TESYLtVSSHPHPRD; SysPTM
T214KTLCGtPNYIAPkinasePhosphoSitePlus; SysPTM
S2AVTAHPRD
T341NRKPLtVLNKGPhosphoSitePlus
S383LQQLHsVNASKPhosphoSitePlus
S137LCRRRsLLELHPkinasePhosphoSitePlus
T498AGANItPREGDPhosphoSitePlus; HPRD; SysPTM
S461RDGTEsYLTVSPOLO_boxPhosphoSitePlus; SysPTM
S326IPPRFsIAPSSPhosphoSitePlus
S375VDCHLsDMLQQPhosphoSitePlus; HPRD; SysPTM
S466SYLTVsSHPNSPOLO_boxPhosphoSitePlus
Y309FFTSGyIPARLPhosphoSitePlus
T214KTLCGtPNYIAHPRD; phosphoELM; SysPTM
S578CKELAsRLRYAPOLO_boxPhosphoSitePlus
S450YNDGDsLQYIEPOLO_boxPhosphoSitePlus; SysPTM
S49LVDPRsRRRYVPhosphoSitePlus
T210GERKKtLCGTPHPRD; phosphoELM; RegPhos; SysPTM
Y217CGTPNyIAPEVPkinasePhosphoSitePlus
S597SSRSAsNRLKAPhosphoSitePlus
S565RTYRLsLLEEYPOLO_boxPhosphoSitePlus
S137LCRRRsLLELHphosphoELM; RegPhos

Dephosphorylation site
PLK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000300093R12LGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000300093Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PLK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PLK1_HUMANCDC23_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANZN223_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANNINL_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANCEP55_HUMANkinase -> substrateHPRD; RegPhos
PLK1_HUMANTCTP_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
NEK9_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANCDK1_HUMANkinase -> substrateKEGG
PLK1_HUMANCDC27_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANBRCA2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANRAGE_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANALK_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANAPC1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANAPC4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANNPM_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANPLK1_HUMANkinase -> substrateRegPhos
PLK1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANPMYT1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANAPC7_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANECT2_HUMANkinase -> substrateHPRD; RegPhos
PLK1_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
E2AK2_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANNUDC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANWEE1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PLK1_HUMANCHK2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANCCNB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
STK10_HUMANPLK1_HUMANkinase -> substrateRegPhos
PLK1_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANPIN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PLK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
PLK1_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANIRS1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
HASP_HUMANPLK1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANCDK1_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0071168protein localization to chromatinIDAbiological_process
GO:0007067mitosisIMPbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0045736negative regulation of cyclin-dependent protein kiIMPbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0045862positive regulation of proteolysisIDAbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIMPbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0007092activation of mitotic anaphase-promoting complex aIDAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0008017microtubule bindingIDAmolecular_function
GO:0090007regulation of mitotic anaphaseIMPbiological_process
GO:0051443positive regulation of ubiquitin-protein ligase acIMPbiological_process
GO:0010800positive regulation of peptidyl-threonine phosphorIMPbiological_process
GO:0007091mitotic metaphase/anaphase transitionTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0043393regulation of protein bindingIMPbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0051726regulation of cell cycleTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000910cytokinesisIMPbiological_process
GO:0000088mitotic prophaseTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0051233spindle midzoneIDAcellular_component
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0001578microtubule bundle formationIDAbiological_process
GO:0051297centrosome organizationIMPbiological_process
GO:0010997anaphase-promoting complex bindingIPImolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0016567protein ubiquitinationIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0000942condensed nuclear chromosome outer kinetochoreIDAcellular_component
GO:0005819spindleIDAcellular_component
GO:0030496midbodyIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007346regulation of mitotic cell cycleIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0031648protein destabilizationIDAbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0031572G2/M transition DNA damage checkpointIDAbiological_process