| UniProt/SwissProt ID: | RAB4A_HUMAN |
| Description: | RAB4A, member RAS oncogene family [Source:HGNC Symbol;Acc:9781] |
| Location: | chr1 q42.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S199 | LRQLRsPRRAQ | CDC2 | RegPhos |
| S185 | PERMGsGIQYG | PhosphoSitePlus | |
| Y189 | GSGIQyGDAAL | PhosphoSitePlus | |
| T19 | IGNAGtGKSCL | Ras | PhosphoSitePlus |
| S199 | LRQLRsPRRAQ | PhosphoSitePlus | |
| S199 | LRQLRsPRRAQ | CDK_group | phosphoELM; RegPhos |
| S204 | LRQLRsPRRAQ | CDK1 | HPRD |
| T132 | ADREVtFLEAS | Ras | PhosphoSitePlus |
| T24 | IGNAGtGKSCL | HPRD | |
| S137 | TFLEAsRFAQE | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RAB4A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355651 | A208T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000355651 | A208T | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RAB4A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAB4A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | RAB4A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030100 | regulation of endocytosis | IEA | biological_process |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0008565 | protein transporter activity | IEA | molecular_function |
| GO:0005768 | endosome | IEA | cellular_component |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0006184 | GTP catabolic process | IDA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |