Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CDC16_HUMAN
Description:cell division cycle 16 [Source:HGNC Symbol;Acc:1720]
Location:chr13 q34
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S614MMLETsMSDHphosphoELM
T254MCYKLtSVVMEPhosphoSitePlus
S586TPLETsRKTPDPhosphoSitePlus
S112YLKDEsGFKDPPhosphoSitePlus; phosphoELM; RegPhos
S490IGYIHsLMGNFphosphoELM; RegPhos
S560LKNIIsPPWDFCDC2(CDK1RegPhos; SysPTM
S560LKNIIsPPWDFPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T589ETSRKtPDSRPPhosphoSitePlus; phosphoELM
S490IGYIHsLMGNFTPR_1PhosphoSitePlus
T581EETGLtPLETSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S614MMLETsMSDHSPhosphoSitePlus
T581EETGLtPLETSCDC2(CDK1RegPhos; SysPTM
S595PDSRPsLEETFPhosphoSitePlus; phosphoELM; RegPhos
S607IEMNEsDMMLEPhosphoSitePlus; phosphoELM
T599PSLEEtFEIEMPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
CDC16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000252457*620YCOSMICIntestines Cancer16959974

Differential expressed protein
CDC16_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CDC16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCDC16_HUMANkinase -> substrateRegPhos
CDK1_HUMANCDC16_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection
hsa04114Oocyte meiosis
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000278mitotic cell cycleTASbiological_process
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0005680anaphase-promoting complexIDAcellular_component
GO:0005819spindleTAScellular_component
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0070979protein K11-linked ubiquitinationIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005876spindle microtubuleIDAcellular_component
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0007088regulation of mitosisTASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0051301cell divisionIEAbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process


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