| UniProt/SwissProt ID: | CDC16_HUMAN |
| Description: | cell division cycle 16 [Source:HGNC Symbol;Acc:1720] |
| Location: | chr13 q34 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S614 | MMLETsMSDH | phosphoELM | |
| T254 | MCYKLtSVVME | PhosphoSitePlus | |
| S586 | TPLETsRKTPD | PhosphoSitePlus | |
| S112 | YLKDEsGFKDP | PhosphoSitePlus; phosphoELM; RegPhos | |
| S490 | IGYIHsLMGNF | phosphoELM; RegPhos | |
| S560 | LKNIIsPPWDF | CDC2(CDK1 | RegPhos; SysPTM |
| S560 | LKNIIsPPWDF | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T589 | ETSRKtPDSRP | PhosphoSitePlus; phosphoELM | |
| S490 | IGYIHsLMGNF | TPR_1 | PhosphoSitePlus |
| T581 | EETGLtPLETS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S614 | MMLETsMSDHS | PhosphoSitePlus | |
| T581 | EETGLtPLETS | CDC2(CDK1 | RegPhos; SysPTM |
| S595 | PDSRPsLEETF | PhosphoSitePlus; phosphoELM; RegPhos | |
| S607 | IEMNEsDMMLE | PhosphoSitePlus; phosphoELM | |
| T599 | PSLEEtFEIEM | PhosphoSitePlus; phosphoELM; RegPhos | |
| Dephosphorylation site |
| CDC16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000252457 | *620Y | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| CDC16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDC16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CDC16_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | CDC16_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| hsa04114 | Oocyte meiosis |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04110 | Cell cycle |
| hsa04914 | Progesterone-mediated oocyte maturation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0005680 | anaphase-promoting complex | IDA | cellular_component |
| GO:0005819 | spindle | TAS | cellular_component |
| GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0070979 | protein K11-linked ubiquitination | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005876 | spindle microtubule | IDA | cellular_component |
| GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007088 | regulation of mitosis | TAS | biological_process |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | TAS | biological_process |