| UniProt/SwissProt ID: | H11_HUMAN |
| Description: | histone cluster 1, H1a [Source:HGNC Symbol;Acc:4715] |
| Location: | chr6 p22.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2 | MSETVpP | CDC2(CDK1 | RegPhos |
| S165 | AATRKsSKNPK | Ald_Xan_dh_C2 | PhosphoSitePlus |
| T152 | KKSVKtPKKAK | Ald_Xan_dh_C2 | PhosphoSitePlus |
| T4 | MSETVpPAP | CDC2(CDK1 | RegPhos |
| T162 | KKPAAtRKSSK | Ald_Xan_dh_C2 | PhosphoSitePlus; SysPTM |
| T204 | VTKPKtAKPKK | Ald_Xan_dh_C2 | PhosphoSitePlus |
| Y74 | LAAAGyDVEKN | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| T4 | PPAP | HPRD; phosphoELM | |
| S183 | KKVAKsPAKAK | Ald_Xan_dh_C2 | PhosphoSitePlus |
| S166 | ATRKSsKNPKK | Ald_Xan_dh_C2 | PhosphoSitePlus |
| S107 | TGASGsFKLNK | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| T4 | MSETVpPAP | CDC2 | RegPhos |
| S165 | AATRKsSKNPK | HPRD | |
| S81 | VEKNNsRIKLG | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| S2 | MSETVpP | CDC2 | RegPhos |
| S2 | TVPP | HPRD; phosphoELM | |
| T102 | VQTKGtGASGS | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| S166 | ATRKSsKNPKK | HPRD | |
| T95 | LVSKGtLVQTK | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| S61 | ERGGVsLAALK | Linker_histone; Ald_Xan_d | PhosphoSitePlus |
| T4 | PPAP | CDK1 | HPRD |
| T162 | KKPAAtRKSSK | HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| H11_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000244573 | P169A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000244573 | T95R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000244573 | A71V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000244573 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 0.65 | 19016532 |
| Hyperphosphorylation site |
| H11_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | H11_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | H11_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| H11_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0006334 | nucleosome assembly | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000786 | nucleosome | IEA | cellular_component |
| GO:0000790 | nuclear chromatin | IDA | cellular_component |