Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:H11_HUMAN
Description:histone cluster 1, H1a [Source:HGNC Symbol;Acc:4715]
Location:chr6 p22.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2MSETVpPCDC2(CDK1RegPhos
S165AATRKsSKNPKAld_Xan_dh_C2PhosphoSitePlus
T152KKSVKtPKKAKAld_Xan_dh_C2PhosphoSitePlus
T4MSETVpPAPCDC2(CDK1RegPhos
T162KKPAAtRKSSKAld_Xan_dh_C2PhosphoSitePlus; SysPTM
T204VTKPKtAKPKKAld_Xan_dh_C2PhosphoSitePlus
Y74LAAAGyDVEKNLinker_histone; Ald_Xan_dPhosphoSitePlus
T4PPAPHPRD; phosphoELM
S183KKVAKsPAKAKAld_Xan_dh_C2PhosphoSitePlus
S166ATRKSsKNPKKAld_Xan_dh_C2PhosphoSitePlus
S107TGASGsFKLNKLinker_histone; Ald_Xan_dPhosphoSitePlus
T4MSETVpPAPCDC2RegPhos
S165AATRKsSKNPKHPRD
S81VEKNNsRIKLGLinker_histone; Ald_Xan_dPhosphoSitePlus
S2MSETVpPCDC2RegPhos
S2TVPPHPRD; phosphoELM
T102VQTKGtGASGSLinker_histone; Ald_Xan_dPhosphoSitePlus
S166ATRKSsKNPKKHPRD
T95LVSKGtLVQTKLinker_histone; Ald_Xan_dPhosphoSitePlus
S61ERGGVsLAALKLinker_histone; Ald_Xan_dPhosphoSitePlus
T4PPAPCDK1HPRD
T162KKPAAtRKSSKHPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
H11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244573P169ACOSMICOvarian Cancer21720365
ENSP00000244573T95RCOSMICOvarian Cancer21720365
ENSP00000244573A71VCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000244573Hepatocellular CarcinomaMetastasiscell lineDown0.6519016532

Hyperphosphorylation site
H11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANH11_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANH11_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
H11_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0007283spermatogenesisIEAbiological_process
GO:0006334nucleosome assemblyIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000786nucleosomeIEAcellular_component
GO:0000790nuclear chromatinIDAcellular_component


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