| UniProt/SwissProt ID: | CSK2B_HUMAN |
| Description: | casein kinase 2, beta polypeptide [Source:HGNC Symbol;Acc:2460] |
| Location: | chrHSCHR6_MHC_QBL p2 |
| Node attribute: | substrate; kinase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2 | SEEV | CK2_group | phosphoELM |
| S205 | QLQAAsNFKSP | HPRD | |
| S2 | SEEV | phosphoELM | |
| S4 | MSSSEeVSW | RegPhos | |
| S69 | DNPNQsDLIEQ | HPRD; SysPTM | |
| S2 | MSSSEeV | autocatalysis | RegPhos |
| S3 | MSSSEeVS | CK2 beta | RegPhos |
| S3 | MSSSEeVS | RegPhos | |
| S11 | EVSWIsWFCGL | HPRD | |
| S209 | ASNFKsPVKTI | RegPhos; SysPTM | |
| S2 | MSSSEeV | P67870(Casein kinase II ) | RegPhos |
| S8 | SSEEVsWISWF | HPRD | |
| S3 | MSSSEeVS | CK2_group | RegPhos |
| S2 | MSSSEeV | CK2 beta | RegPhos |
| S4 | EVSW | HPRD; phosphoELM | |
| S209 | ASNFKsPVKT | phosphoELM; SysPTM | |
| S3 | EEVS | CK2_group | phosphoELM |
| S3 | EEVS | CSNK2B | HPRD |
| S209 | ASNFKsPVKTI | CDC2 | RegPhos; SysPTM |
| S3 | MSSSEeVS | P67870(Casein kinase II ) | RegPhos |
| S2 | MSSSEeV | CK2_group | RegPhos |
| S3 | EEVS | phosphoELM | |
| S209 | ASNFKsPVKT | CDK1 | HPRD; phosphoELM; SysPTM |
| S209 | ASNFKsPVKT | CDK_group | phosphoELM; SysPTM |
| S2 | SEEV | CSNK2B | HPRD |
| S209 | ASNFKsPVKTI | CDC2(CDK1 | RegPhos; SysPTM |
| S209 | ASNFKsPVKTI | CDK_group | RegPhos; SysPTM |
| Y197 | IHPMAyQLQLQ | HPRD | |
| T213 | KSPVKt | HPRD; SysPTM | |
| S3 | EEVS | CK2_beta | phosphoELM |
| S2 | SEEV | CK2_beta | phosphoELM |
| Dephosphorylation site |
| CSK2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365026 | S209C | COSMIC | Hepatocellular Carcinoma | ENSP00000365025 | S209C | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| CSK2B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CSK2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK2B_HUMAN | UB2R1_HUMAN | kinase -> substrate | HPRD |
| CDK1_HUMAN | CSK2B_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CSK2B_HUMAN | BRCA1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | CSK2B_HUMAN | kinase -> substrate | RegPhos |
| CSK2B_HUMAN | C163A_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | RBX2_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | CSK2B_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | NEP_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | CTDP1_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | IF5_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | OCLN_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | IRS1_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | HXB6_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | CTNB1_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | USO1_HUMAN | kinase -> substrate | HPRD |
| CSK2B_HUMAN | P53_HUMAN | kinase -> substrate | HPRD |
| ETS1_HUMAN | CSK2B_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03008 | Ribosome biogenesis in eukaryotes |
| hsa05162 | Measles |
| hsa04064 | NF-kappa B signaling pathway |
| hsa04530 | Tight junction |
| hsa05169 | Epstein-Barr virus infection |
| hsa05168 | Herpes simplex infection |
| hsa04310 | Wnt signaling pathway |
| hsa04520 | Adherens junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043623 | cellular protein complex assembly | NAS | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0051101 | regulation of DNA binding | NAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0033211 | adiponectin-mediated signaling pathway | IDA | biological_process |
| GO:0005956 | protein kinase CK2 complex | NAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0032927 | positive regulation of activin receptor signaling | IMP | biological_process |
| GO:0045859 | regulation of protein kinase activity | NAS | biological_process |
| GO:0061154 | endothelial tube morphogenesis | IMP | biological_process |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0043537 | negative regulation of blood vessel endothelial ce | IDA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0019887 | protein kinase regulator activity | NAS | molecular_function |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0010862 | positive regulation of pathway-restricted SMAD pro | IDA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |