| UniProt/SwissProt ID: | TLE2_HUMAN |
| Description: | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) [Source:HGNC Symbol;Acc:11838] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S249 | PSEPPsPATTP | CDC2 | RegPhos |
| S182 | VEAEGsRVERA | PhosphoSitePlus | |
| S228 | SGPYEsDEDKS | CK2_group | RegPhos |
| T253 | PSPATtPCGKV | CDC2 | RegPhos |
| S281 | ASSLGsPLPRA | PhosphoSitePlus; HPRD; phosphoELM | |
| Y726 | SRNNKyIVTGS | WD40 | PhosphoSitePlus |
| S672 | LHLHEsCVLSL | WD40 | PhosphoSitePlus |
| Y665 | RKPEKyQLHLH | WD40 | PhosphoSitePlus |
| T729 | NKYIVtGSGDK | WD40 | PhosphoSitePlus |
| S676 | ESCVLsLKFAS | WD40 | PhosphoSitePlus |
| S731 | YIVTGsGDKKA | WD40 | PhosphoSitePlus |
| S271 | RDLVDsPASLA | PhosphoSitePlus; HPRD; phosphoELM | |
| S712 | FQSKEsSSVLS | WD40 | PhosphoSitePlus |
| Dephosphorylation site |
| TLE2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TLE2_HUMAN do not have mutation site. |
| Differential expressed protein |
| TLE2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TLE2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | TLE2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| TLE2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0009887 | organ morphogenesis | TAS | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IDA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |