| UniProt/SwissProt ID: | PP1A_HUMAN |
| Description: | protein phosphatase 1, catalytic subunit, alpha isozyme [Source:HGNC Symbol;Acc:9281] |
| Location: | chr11 q13.2 |
| Node attribute: | phosphotase; substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S325 | TPPRNsAKAKK | PhosphoSitePlus | |
| Y134 | SINRIyGFYDE | Metallophos | PhosphoSitePlus |
| T320 | GGRPItPPRNS | CDK_group | phosphoELM; RegPhos; SysPTM |
| S129 | NHECAsINRIY | Metallophos | PhosphoSitePlus |
| Y137 | RIYGFyDECKR | Metallophos | PhosphoSitePlus |
| S11 | KLNLDsIIGRL | PhosphoSitePlus; HPRD | |
| Y255 | VVEDGyEFFAK | PhosphoSitePlus | |
| T320 | GGRPItPPRNS | CDC2(CDK1 | RegPhos; SysPTM |
| T320 | GGRPItPPRNS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T320 | GGRPItPPRNS | CDK2 | RegPhos; SysPTM |
| T320 | GGRPItPPRNS | CDK1 | phosphoELM; SysPTM |
| T331 | GGRPItPPRNS | HPRD | |
| S22 | LEVQGsRPGKN | PhosphoSitePlus; HPRD | |
| Y306 | KNKGKyGQFSG | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T320 | NPGGRPItPPRNSAK | HPRD | |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365936 | G80S | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000365936 | Breast Cancer | Treatment (Antiestrogen-sensitive vs. Antiestrogen-resistant) | cell line | Down | 0.43 | 14557597 | ENSP00000365936 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.45 | 20739354 | ENSP00000365936 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Down | 0.24 | 15169874 |
| Hyperphosphorylation site |
| PP1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | PP1A_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | PP1A_HUMAN | kinase -> substrate | RegPhos |
| PP1A_HUMAN | AXIN1_HUMAN | phosphatase -> substrate | HPRD |
| PP1A_HUMAN | CALL6_HUMAN | phosphatase -> substrate | KEGG |
| PP1A_HUMAN | KPCD_HUMAN | phosphatase -> substrate | HPRD |
| PP1A_HUMAN | GYS1_HUMAN | phosphatase -> substrate | KEGG |
| PP1A_HUMAN | PYR1_HUMAN | phosphatase -> substrate | HPRD |
| PP1A_HUMAN | H2AX_HUMAN | phosphatase -> substrate | HPRD |
| AKT3_HUMAN | PP1A_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04114 | Oocyte meiosis |
| hsa05034 | Alcoholism |
| hsa04270 | Vascular smooth muscle contraction |
| hsa03015 | mRNA surveillance pathway |
| hsa04510 | Focal adhesion |
| hsa04720 | Long-term potentiation |
| hsa04910 | Insulin signaling pathway |
| hsa05031 | Amphetamine addiction |
| hsa04728 | Dopaminergic synapse |
| hsa05168 | Herpes simplex infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0043021 | ribonucleoprotein complex binding | IEA | molecular_function |
| GO:0070688 | MLL5-L complex | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0043197 | dendritic spine | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030512 | negative regulation of transforming growth factor | TAS | biological_process |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005981 | regulation of glycogen catabolic process | IEA | biological_process |
| GO:0019433 | triglyceride catabolic process | TAS | biological_process |
| GO:0030324 | lung development | IEA | biological_process |
| GO:0005977 | glycogen metabolic process | IEA | biological_process |
| GO:0000164 | protein phosphatase type 1 complex | IEA | cellular_component |
| GO:0042587 | glycogen granule | IEA | cellular_component |
| GO:0004721 | phosphoprotein phosphatase activity | IEA | molecular_function |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0006629 | lipid metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005979 | regulation of glycogen biosynthetic process | IEA | biological_process |
| GO:0005654 | nucleoplasm | IEA | cellular_component |
| GO:0043204 | perikaryon | IEA | cellular_component |
| GO:0072357 | PTW/PP1 phosphatase complex | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0048754 | branching morphogenesis of a tube | IEA | biological_process |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |