Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AMPH_HUMAN
Description:amphiphysin [Source:HGNC Symbol;Acc:471]
Location:chr7 p14.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S293PARPRsPSQTRPhosphoSitePlus
S507VIEPAsNHEEEHPRD
S464AGEGVsLEEAKHPRD
T260LRIAKtPSPPEPhosphoSitePlus; HPRD
T456DLGMDtRAEEPPhosphoSitePlus
S285TLAPAsPAPARCDK1HPRD
S285TLAPAsPAPARPhosphoSitePlus
S549VIEPAsNHEEEPhosphoSitePlus; HPRD
S285TLAPAsPAPARCDK_groupphosphoELM; RegPhos
S272PSPLPsPTASPCDK_groupphosphoELM; RegPhos
T6MADIKtGIFAKIFT57PhosphoSitePlus; SysPTM
S276PSPTAsPNHTLCDK5HPRD; RegPhos
S272PSPLPsPTASPCDC2RegPhos
T6IFAKphosphoELM; SysPTM
T387WDLWTtSTDLVPhosphoSitePlus
T350VKKEEtLLDLDPhosphoSitePlus
S272PSPLPsPTASPPhosphoSitePlus
S276PSPTAsPNHTLCDC2RegPhos
S506AGEGVsLEEAKHPRD; RegPhos
S272PSPLPsPTASPCDK1HPRD
S272PSPLPsPTASPCDK5HPRD; RegPhos
T310PLPKVtPTKELPhosphoSitePlus
S250IQGAPsDSGPLRegPhos
T312PKVTPtKELQQPhosphoSitePlus
S74GMQEAsMKLTEBAR; IFT57PhosphoSitePlus
Y145RKLVDyDSARHBARPhosphoSitePlus
T34GKADEtKDEQFBAR; IFT57PhosphoSitePlus
S276PSPTAsPNHTLCDK1HPRD
S285TLAPAsPAPARCDK5HPRD; RegPhos
S276PSPTAsPNHTLCDK_groupphosphoELM; RegPhos
S285TLAPAsPAPARCDC2RegPhos
S276PSPTAsPNHTLPhosphoSitePlus
S293PARPRsPSQTRDYRK1AphosphoELM
S295RPRSPsQTRKGPhosphoSitePlus
S262IAKTPsPPEEPPhosphoSitePlus
T445PLAAVtPAVGLPhosphoSitePlus

Dephosphorylation site
AMPH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348602D353NCOSMICMelanoma21499247
ENSP00000348602P273LCOSMICSkin Cancer21984974
ENSP00000348602W382*COSMICSkin Cancer21984974
ENSP00000348602P129SCOSMICSkin Cancer21984974
ENSP00000348602E558KCOSMICSkin Cancer21984974
ENSP00000348602P249SCOSMICOvarian Cancer21720365
ENSP00000348602T386MCOSMICHepatocellular Carcinoma

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000348602Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504

Hyperphosphorylation site
AMPH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANAMPH_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANAMPH_HUMANkinase -> substrateRegPhos
CDK1_HUMANAMPH_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007612learningIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0008021synaptic vesicleTAScellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006897endocytosisTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0030672synaptic vesicle membraneIEAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0048488synaptic vesicle endocytosisIEAbiological_process
GO:0015629actin cytoskeletonTAScellular_component
GO:0008021synaptic vesicleIEAcellular_component


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