Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FEN1_HUMAN
Description:flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:3650]
Location:chr11 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S101ELAKRsERRAEXPG_NPhosphoSitePlus
S335KSRQGsTQGRLPhosphoSitePlus; HPRD
S187CLTFGsPVLMRCDK1HPRD; phosphoELM
S187CLTFGsPVLMRCDC2RegPhos
T195LMRHLtASEAKHPRD
Y268LDPNKyPVPENPhosphoSitePlus
Y234LLGSDyCESIRPhosphoSitePlus
S187CLTFGsPVLMRXPG_IPhosphoSitePlus
S187CLTFGsPVLMRCDC2(CDK1RegPhos
T195LMRHLtASEAKXPG_IPhosphoSitePlus
S197RHLTAsEAKKLXPG_IPhosphoSitePlus
S197RHLTAsEAKKLHPRD
T364EPKGStKKKAKPhosphoSitePlus; HPRD

Dephosphorylation site
FEN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000305480E318VTCGAOvarian Cancer21720365, 18772890
ENSP00000305480E318VCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000305480Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
FEN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANFEN1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03410Base excision repair
hsa03030DNA replication
hsa03450Non-homologous end-joining

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007613memoryIEAbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0008309double-stranded DNA specific exodeoxyribonuclease TASmolecular_function
GO:0004523ribonuclease H activityIDAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0004527exonuclease activityIEAmolecular_function
GO:0004518nuclease activityIEAmolecular_function
GO:0043137DNA replication, removal of RNA primerIDAbiological_process
GO:0032201telomere maintenance via semi-conservative replicaTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003684damaged DNA bindingTASmolecular_function
GO:0030145manganese ion bindingIEAmolecular_function
GO:0009650UV protectionTASbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:00084095'-3' exonuclease activityIDAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0004519endonuclease activityTASmolecular_function
GO:0003690double-stranded DNA bindingTASmolecular_function
GO:0000723telomere maintenanceTASbiological_process
GO:0000722telomere maintenance via recombinationTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0048256flap endonuclease activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0006284base-excision repairTASbiological_process
GO:00171085'-flap endonuclease activityIMPmolecular_function
GO:0005515protein bindingIPImolecular_function


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