Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NDE1_HUMAN
Description:nudE nuclear distribution E homolog 1 (A. nidulans) [Source:HGNC Symbol;Acc:17619]
Location:chr16 p13.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S239RGLDDsTGGTPCDK1HPRD
S282LVYDQsPNRTGNUDE_CPhosphoSitePlus
S239RGLDDsTGGTPMAPK1HPRD
T240GLDDStGGTPLNUDE_CPhosphoSitePlus
T246GGTPLtPAARINUDE_CPhosphoSitePlus
S231LNTPGsFRRGLHPRD; phosphoELM
T308RRPSStSVPLGNUDE_CPhosphoSitePlus
T240GLDDStGGTPLHPRD; phosphoELM
S231LNTPGsFRRGLNUDE_CPhosphoSitePlus
T243DSTGGtPLTPANUDE_CPhosphoSitePlus
S239RGLDDsTGGTPNUDE_CPhosphoSitePlus
S307ERRPSsTSVPLHPRD; phosphoELM; RegPhos
T215GSVPStPIAHRStriatin; NUDE_CPhosphoSitePlus
S195RTPMPsSVEAEHPRD
S239RGLDDsTGGTPCDC2RegPhos
T215GSVPStPIAHRCDC2RegPhos
S291TGGPAsGRSSKHPRD
T228SSSLNtPGSFRNUDE_CPhosphoSitePlus
S291TGGPAsGRSSKNUDE_CPhosphoSitePlus
Y279CRNLVyDQSPNNUDE_CPhosphoSitePlus
S214TGSVPsTPIAHStriatin; NUDE_CPhosphoSitePlus
S224HRGPSsSLNTPNUDE_CPhosphoSitePlus
S9SGKTFsSEEEETPR_MLP1_2PhosphoSitePlus
T215GSVPStPIAHRErk2RegPhos
T215GSVPStPIAHRCDK1HPRD
S10GKTFSsEEEEATPR_MLP1_2PhosphoSitePlus
T215GSVPStPIAHRMAPK1HPRD
S196TPMPSsVEAERHPRD
S211VQATGsVPSTPStriatin; NUDE_CPhosphoSitePlus
S239RGLDDsTGGTPErk2RegPhos
S307ERRPSsTSVPLNUDE_CPhosphoSitePlus
S306GERRPsSTSVPNUDE_CPhosphoSitePlus
S211VQATGsVPSTPHPRD; phosphoELM
S309RPSSTsVPLGDHPRD
T7EDSGKtFSSEETPR_MLP1_2PhosphoSitePlus
S309RPSSTsVPLGDNUDE_CPhosphoSitePlus
T215GSVPStPIAHRphosphoELM
T243DSTGGtPLTPAHPRD; phosphoELM
T131RAKRAtIMSLEStriatin; DUF2009PhosphoSitePlus
T246GGTPLtPAARIHPRD; phosphoELM; RegPhos
S239RGLDDsTGGTPphosphoELM
S282LVYDQsPNRTGHPRD; phosphoELM; RegPhos
S223AHRGPsSSLNTNUDE_CPhosphoSitePlus
S306GERRPsSTSVPHPRD; phosphoELM; RegPhos
T191QEKPRtPMPSSStriatin; DUF2009; NUDE_CPhosphoSitePlus
Y279CRNLVyDQSPNHPRD; phosphoELM; RegPhos
S214TGSVPsTPIAHHPRD
T228SSSLNtPGSFRHPRD; phosphoELM

Dephosphorylation site
NDE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379642S291YTCGAOvarian Cancer21720365, 18772890
ENSP00000379643S291YTCGAOvarian Cancer21720365, 18772890
ENSP00000379641*347SCOSMICOvarian Cancer21720365
ENSP00000379642S291YCOSMICOvarian Cancer21720365
ENSP00000345892S291YTCGAOvarian Cancer21720365, 18772890
ENSP00000379641*347CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379641Breast CancerNormal vs. Cancercell lineUp7.820052998
ENSP00000379641Breast CancerNormal vs. Cancercell lineUp6.420052998
ENSP00000379641Breast CancerMetastasiscell lineDown0.8520052998

Hyperphosphorylation site
NDE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANNDE1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANNDE1_HUMANkinase -> substrateRegPhos
MK01_HUMANNDE1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
NDE1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007020microtubule nucleationIEAbiological_process
GO:0051298centrosome duplicationIEAbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0008017microtubule bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005819spindleIEAcellular_component
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0005813centrosomeIEAcellular_component
GO:0031616spindle pole centrosomeIEAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0051303establishment of chromosome localizationIMPbiological_process
GO:0031023microtubule organizing center organizationIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0032154cleavage furrowIEAcellular_component
GO:0000132establishment of mitotic spindle orientationIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001764neuron migrationIEAbiological_process
GO:0005815microtubule organizing centerIEAcellular_component
GO:0007405neuroblast proliferationIEAbiological_process
GO:0047496vesicle transport along microtubuleIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process