Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:41_HUMAN
Description:erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) [Source:HGNC Symbol;Acc:3377]
Location:chr1 p35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S470RLSTHsPFRTLHPRD
S342AAAVDsADRSPHPRD
Y437DGENIyIRHSNEGFRHPRD
Y660DGENIyIRHSNPhosphoSitePlus
S411SYKRSsFFIKIHPRD
Y767TKTITyEAAQT4_1_CTDPhosphoSitePlus
T220SLLDDtVYECVFERM_NPhosphoSitePlus
Y374ELHKSyRSMTPFERM_MPhosphoSitePlus
T468DKRLStHSPFRHPRD
S555DSADRsPRPTSPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S542KRASRsLDGAAphosphoELM; RegPhos
S674EDLDKsQEEIKSABPhosphoSitePlus
S432EDLDKsQEEIKHPRD
S505ASKRAsRSLDGHPRD
S520DSADRsPRPTSHPRD
S149SLDLHsLSSAEPhosphoSitePlus
S331ASKRAsRSLDGHPRD
S620WDKRLsTHSPFHPRD
T155LSSAEtQPAQEPhosphoSitePlus
S521QTRQAsALIDRFAPhosphoSitePlus
S151DLHSLsSAETQPhosphoSitePlus
S712RLSTHsPFRTLCDC2RegPhos; SysPTM
S623RLSTHsPFRTLHPRD
S543GVLDAsAKKTVPRKCBHPRD
T60ASNGDtPTHEDPhosphoSitePlus
S237SYKRSsFFIKIHPRD
S14TEAENsQHQQKPhosphoSitePlus
S712RLSTHsPFRTLSABPhosphoSitePlus; SysPTM
T859VVHQEtEIADE4_1_CTDPhosphoSitePlus
Y660DGENIyIRHSNEGFRphosphoELM; RegPhos
S467WDKRLsTHSPFHPRD
S84LSRLFsSFLKRPhosphoSitePlus; HPRD
T806TQITKtVKGGI4_1_CTDPhosphoSitePlus
S486WDKRLsTHSPFHPRD
S812VKGGIsETRIE4_1_CTDPhosphoSitePlus
S346DSADRsPRPTSHPRD
S516AAAVDsADRSPHPRD
T710DKRLStHSPFRSABPhosphoSitePlus; SysPTM
S540ASKRAsRSLDGRegPhos
S451EDLDKsQEEIKHPRD
T565SAPAItQGQVAPhosphoSitePlus
Y418DGENIyIRHSNEGFRHPRD
S521QTRQAsALIDRPKCbRegPhos
S560SPRPTsAPAITPhosphoSitePlus
S410ISYKRsSFFIKHPRD
S191EESPQsKAETEPhosphoSitePlus; HPRD; phosphoELM
S709WDKRLsTHSPFSABPhosphoSitePlus
Y459GEQEQyESTIGFERM_CPhosphoSitePlus
S684KKHHAsISELKSABPhosphoSitePlus
S542KRASRsLDGAAFAPhosphoSitePlus
S236ISYKRsSFFIKHPRD
S152LHSLSsAETQPPhosphoSitePlus
S595KKHHAsISELKHPRD
T60ASNGDtPTHEDCDC2RegPhos
S333KRASRsLDGAAHPRD
S92LKRPKsQVSEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S200TELKAsQKPIRPhosphoSitePlus
S551AAAVDsADRSPphosphoELM
T195QSKAEtELKASPhosphoSitePlus
T487DKRLStHSPFRHPRD
S461KKHHAsISELKHPRD
Y222LDDTVyECVVERegPhos
T716HSPFRtLNINGPhosphoSitePlus
S507KRASRsLDGAAHPRD
S312QTRQAsALIDRPRKCBHPRD
S442KKHHAsISELKHPRD
S369GVLDAsAKKTVHPRD
S489RLSTHsPFRTLHPRD
S85SRLFSsFLKRPPhosphoSitePlus; HPRD
S712RLSTHsPFRTLphosphoELM; SysPTM
Y222LDDTVyECVVEFERM_NPhosphoSitePlus
S188EVKEEsPQSKAPhosphoSitePlus; HPRD; phosphoELM
T794TITSEtPSSTT4_1_CTDPhosphoSitePlus
S578GVLDAsAKKTVPKCbRegPhos
T621DKRLStHSPFRHPRD

Dephosphorylation site
41_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317597W481SCOSMICOvarian Cancer21720365
ENSP00000345259W704STCGAOvarian Cancer21720365, 18772890
ENSP00000362904W704STCGAOvarian Cancer21720365, 18772890
ENSP00000317597S569PCOSMICOvarian Cancer21720365

Differential expressed protein
41_HUMAN is not differential expressed protein.

Hyperphosphorylation site
41_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EGFR_HUMAN41_HUMANkinase -> substrateHPRD; RegPhos
KPCB_HUMAN41_HUMANkinase -> substrateHPRD
CDK1_HUMAN41_HUMANkinase -> substrateRegPhos
ZAGL2_HUMAN41_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003779actin bindingIEAmolecular_function
GO:0030866cortical actin cytoskeleton organizationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008091spectrinTAScellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component
GO:00055451-phosphatidylinositol bindingIDAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0030036actin cytoskeleton organizationNASbiological_process
GO:0016020membraneIEAcellular_component
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0030863cortical cytoskeletonIDAcellular_component
GO:0014731spectrin-associated cytoskeletonTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0030507spectrin bindingTASmolecular_function
GO:0043234protein complexIDAcellular_component
GO:0008015blood circulationTASbiological_process
GO:0019898extrinsic to membraneIEAcellular_component
GO:0005200structural constituent of cytoskeletonTASmolecular_function