Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TSC1_HUMAN
Description:tuberous sclerosis 1 [Source:HGNC Symbol;Acc:12362]
Location:chr9 q34.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1141DGPHPsPPTPDPhosphoSitePlus
Y406CHSDDyVHISLHamartinPhosphoSitePlus
S511PFYRDsLPGSQHamartinPhosphoSitePlus
T390GTPLGtPATSPHamartinPhosphoSitePlus
T417PQATVtPPRKECDC2(CDK1RegPhos
Y312ATSTPySTSRLHamartinPhosphoSitePlus
S108WKHKLsQAPLLHamartinPhosphoSitePlus
S598RVGFGsGQPPPHPRD; phosphoELM; SysPTM
S584SIFTPsPCKIPCDC2(CDK1RegPhos
T873NKHSDtTKEVEPhosphoSitePlus
S511PFYRDsLPGSQHPRD; phosphoELM
T393LGTPAtSPPPAHamartinPhosphoSitePlus
S515DSLPGsQRKTHHamartinPhosphoSitePlus
S1024KTPRPsSARGSPhosphoSitePlus
Y304DTQNSyGCATSHamartinPhosphoSitePlus
S1102RNKSEsQCDEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1144HPSPPtPDSVGPhosphoSitePlus
T417PQATVtPPRKEHamartinPhosphoSitePlus
T1047SSELStPEKPPCDC2(CDK1RegPhos
S598RVGFGsGQPPPHamartinPhosphoSitePlus; SysPTM
S115APLLPsLLKCLHamartinPhosphoSitePlus
S505RGGFDsPFYRDHamartinPhosphoSitePlus; SysPTM
S584SIFTPsPCKIPCDC2RegPhos
S871LQNKHsDTTKEPhosphoSitePlus
Y508FDSPFyRDSLPHamartinPhosphoSitePlus
T874KHSDTtKEVEMPhosphoSitePlus
T1047SSELStPEKPPCDK1HPRD; phosphoELM
S295ADVTTsPYADTHamartinPhosphoSitePlus
T417PQATVtPPRKECDC2RegPhos
S584SIFTPsPCKIPCDK1HPRD; phosphoELM
Y297VTTSPyADTQNHamartinPhosphoSitePlus
T310GCATStPYSTSHamartinPhosphoSitePlus
S1025TPRPSsARGSSPhosphoSitePlus
T1047SSELStPEKPPPhosphoSitePlus
S584SIFTPsPCKIPHamartinPhosphoSitePlus
S303ADTQNsYGCATHamartinPhosphoSitePlus
S205VSFLRsHYSMKHamartinPhosphoSitePlus
T1047SSELStPEKPPCDC2RegPhos
S505RGGFDsPFYRDHPRD; phosphoELM; RegPhos; SysPTM
T417PQATVtPPRKECDK1HPRD; phosphoELM
S1100LFRNKsESQCDPhosphoSitePlus
S487ISRELsEITTAHamartinPhosphoSitePlus
S1046SSSELsTPEKPPhosphoSitePlus
T357VCGMTtPPTSPHamartinPhosphoSitePlus

Dephosphorylation site
TSC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000394524F158CHPIUrinary Bladder Cancer18397877
ENSP00000394524R204LCOSMICLung Cancer18948947
ENSP00000298552R204LDing2008, COSMICLung Cancer18948947
ENSP00000394524H206DHPIUrinary Bladder Cancer18397877
ENSP00000298552P590SDing2008, COSMICLung Cancer18948947
ENSP00000394524D47GCOSMICBreast Cancer20668451
ENSP00000298552S1043NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000394524S1043NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000298552F158CHPIUrinary Bladder Cancer18397877
ENSP00000298552H68RHPIUrinary Bladder Cancer18397877
ENSP00000394524W164*COSMICLymphoma
ENSP00000298552G461ECOSMICMelanoma21499247
ENSP00000394524Q65ECOSMICLung Cancer20668451
ENSP00000394524G461ECOSMICMelanoma21499247
ENSP00000298552D47GCOSMICBreast Cancer20668451
ENSP00000298552Q65ECOSMICLung Cancer20668451
ENSP00000394524H68RHPIUrinary Bladder Cancer18397877
ENSP00000298552F216LHPIUrinary Bladder Cancer18397877
ENSP00000298552L557fs*72COSMICOther Cancer
ENSP00000394524L557fs*72COSMICOther Cancer
ENSP00000298552W164*COSMICLymphoma
ENSP00000298552R245*COSMICHead and Neck Cancer21798893
ENSP00000394524F216LHPIUrinary Bladder Cancer18397877
ENSP00000298552H206DHPIUrinary Bladder Cancer18397877
ENSP00000394524R245*COSMICHead and Neck Cancer21798893
ENSP00000394524P590SCOSMICLung Cancer18948947

Differential expressed protein
TSC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TSC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKKB_HUMANTSC1_HUMANkinase -> substrateKEGG; NetPath
CDK1_HUMANTSC1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANTSC1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolIDAcellular_component
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043234protein complexIDAcellular_component
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0030027lamellipodiumIDAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0030030cell projection organizationIEAbiological_process
GO:0045792negative regulation of cell sizeIEAbiological_process
GO:0051087chaperone bindingIPImolecular_function
GO:0016020membraneIDAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0051894positive regulation of focal adhesion assemblyIDAbiological_process
GO:0006407rRNA export from nucleusIMPbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:0051492regulation of stress fiber assemblyIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006417regulation of translationIDAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0032956regulation of actin cytoskeleton organizationIEAbiological_process
GO:0001952regulation of cell-matrix adhesionIMPbiological_process
GO:0006813potassium ion transportIEAbiological_process
GO:0043666regulation of phosphoprotein phosphatase activityIMPbiological_process
GO:0030426growth coneIEAcellular_component
GO:0007160cell-matrix adhesionIMPbiological_process
GO:0005488bindingIEAmolecular_function
GO:0017148negative regulation of translationIMPbiological_process
GO:0033596TSC1-TSC2 complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0051492regulation of stress fiber assemblyIDAbiological_process
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0051893regulation of focal adhesion assemblyIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0030695GTPase regulator activityIEAmolecular_function
GO:0032868response to insulin stimulusIDAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0032862activation of Rho GTPase activityIDAbiological_process
GO:0044430cytoskeletal partIEAcellular_component
GO:0042552myelinationIEAbiological_process
GO:0005884actin filamentIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005938cell cortexIDAcellular_component
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0050821protein stabilizationIDAbiological_process
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0050808synapse organizationIEAbiological_process
GO:0032007negative regulation of TOR signaling cascadeIMPbiological_process