| UniProt/SwissProt ID: | PTTG1_HUMAN |
| Description: | pituitary tumor-transforming 1 [Source:HGNC Symbol;Acc:9690] |
| Location: | chr5 q33.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S165 | QLGPPsPVKMP | CDC2(CDK1 | RegPhos |
| S171 | PVKMPsPPWES | Securin | PhosphoSitePlus |
| T43 | RSQVStPRFGK | Securin | PhosphoSitePlus |
| S42 | GRSQVsTPRFG | Securin | PhosphoSitePlus |
| S184 | LQSPSsILSTL | Securin | PhosphoSitePlus |
| S165 | QLGPPsPVKMP | CDK1 | HPRD; phosphoELM |
| S39 | ALDGRsQVSTP | Securin | PhosphoSitePlus |
| Y111 | ASDDAyPEIEK | Securin | PhosphoSitePlus |
| S181 | SNLLQsPSSIL | HPRD | |
| T16 | NGEPGtRVVAK | Securin | PhosphoSitePlus |
| S165 | QLGPPsPVKMP | CDC2 | RegPhos |
| S184 | LQSPSsILSTL | HPRD | |
| S28 | GLKLGsGPSIK | Securin | PhosphoSitePlus |
| S183 | LLQSPsSILST | Securin | PhosphoSitePlus |
| S165 | QLGPPsPVKMP | HPRD; phosphoELM; RegPhos | |
| S165 | QLGPPsPVKMP | Securin | PhosphoSitePlus |
| Dephosphorylation site |
| PTTG1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377536 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000344936 | T60N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000430642 | T60N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000377536 | T60N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000430642 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000344936 | *203L | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| PTTG1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTTG1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | PTTG1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | PTTG1_HUMAN | kinase -> substrate | RegPhos |
| P53_HUMAN | PTTG1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| hsa04114 | Oocyte meiosis |
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007283 | spermatogenesis | TAS | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0051276 | chromosome organization | IEA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006259 | DNA metabolic process | IEA | biological_process |
| GO:0007059 | chromosome segregation | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | NAS | molecular_function |