Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRDX1_HUMAN
Description:peroxiredoxin 1 [Source:HGNC Symbol;Acc:9352]
Location:chr1 p34.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S32KDISLsDYKGKAhpC-TSAPhosphoSitePlus
T143ILRQItVNDLPPhosphoSitePlus
Y194QKSKEyFSKHPRD; phosphoELM
T90LAWVNtPKKQGCDC2(CDK1RegPhos
Y194QKSKEyFSKQK1-cysPrx_CPhosphoSitePlus
T90LAWVNtPKKQGCDK1phosphoELM
Y34ISLSDyKGKYVAhpC-TSAPhosphoSitePlus
Y194QKSKEyFSKQKRegPhos
T90LAWVNtPKKQGAhpC-TSAPhosphoSitePlus
Y116TIAQDyGVLKAAhpC-TSAPhosphoSitePlus
T183KPGSDtIKPDV1-cysPrx_CPhosphoSitePlus; SysPTM
T183KPGSDtIKPDVHPRD; phosphoELM; RegPhos; SysPTM
T90LAWVNtPKKQGCDC2RegPhos

Dephosphorylation site
PRDX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000407034S126LBIOMARTBreast Cancer21930507, 21930502
ENSP00000262746S126LBIOMARTBreast Cancer21930507, 21930502
ENSP00000361150S24LBIOMARTBreast Cancer21930507, 21930502
ENSP00000389047S126LBIOMARTBreast Cancer21930507, 21930502
ENSP00000361152S126LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262746Non-small cell lung carcinomaMetastasiscell lineDown17537172
ENSP00000262746Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.2618646787
ENSP00000262746hepatitis B virusNormal vs. CancertissueDown0.3514726492
ENSP00000262746Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000262746Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineUp2.414557597
ENSP00000262746Breast CancerNormal vs. CancertissueUp18257521
ENSP00000262746hepatitis C virusNormal vs. CancertissueDown0.516097030
ENSP00000262746Hepatocellular CarcinomaNormal vs. Cancercell lineDown17214954
ENSP00000262746Hepatocellular CarcinomaMetastasiscell lineDown17214954
ENSP00000262746Hepatocellular CarcinomaMetastasiscell lineDown17214954
ENSP00000262746Hepatocellular CarcinomaTreatment (none vs. Suberonylanilide hydroxamic acid (SAHA) treatment)tissueUp17593366
ENSP00000262746Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000262746Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp9.519137550
ENSP00000262746Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp1419137550
ENSP00000262746Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp16525997
ENSP00000262746Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineUp1516900703
ENSP00000262746Breast CancerNormal vs. CancertissueUp3.320005186
ENSP00000262746Breast CancerNormal vs. Cancercell lineUp2.120052998
ENSP00000262746Breast CancerNormal vs. Cancercell lineUp1.320052998
ENSP00000262746Breast CancerMetastasiscell lineDown0.6220052998
ENSP00000262746chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000262746acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000262746Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000262746Uterine CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000262746Uterine CancerTreatment(21% oxygen vs. 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000262746Head and Neck CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000262746Head and Neck CancerTreatment(21% oxygen vs 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000262746pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
PRDX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RAF1_HUMANPRDX1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPRDX1_HUMANkinase -> substrateRegPhos
CDK4_HUMANPRDX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANPRDX1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04146Peroxisome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019430removal of superoxide radicalsIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0016209antioxidant activityIEAmolecular_function
GO:0042744hydrogen peroxide catabolic processIDAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005782peroxisomal matrixIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005730nucleolusIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0001501skeletal system developmentTASbiological_process
GO:0008379thioredoxin peroxidase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0000302response to reactive oxygen speciesIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0032872regulation of stress-activated MAPK cascadeIEAbiological_process
GO:0004601peroxidase activityIDAmolecular_function
GO:0020037heme bindingIEAmolecular_function
GO:0005759mitochondrial matrixIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0042267natural killer cell mediated cytotoxicityIEAbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0051920peroxiredoxin activityIEAmolecular_function
GO:0034101erythrocyte homeostasisIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0042345regulation of NF-kappaB import into nucleusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006979response to oxidative stressIEAbiological_process
GO:0005719nuclear euchromatinIEAcellular_component
GO:0055114oxidation-reduction processIEAbiological_process