| UniProt/SwissProt ID: | ORN_HUMAN |
| Description: | REX2, RNA exonuclease 2 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:17851] |
| Location: | chr11 q23.2 |
| Node attribute: | PPI(source); substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y122 | LQQAEyEFLSF | HPRD; phosphoELM | |
| Y184 | WYPEEyEFAPK | HPRD; phosphoELM | |
| Y184 | WYPEEyEFAPK | RNase_T | PhosphoSitePlus |
| Y122 | LQQAEyEFLSF | RNase_T | PhosphoSitePlus |
| Dephosphorylation site |
| ORN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ORN_HUMAN do not have mutation site. |
| Differential expressed protein |
| ORN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ORN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | ORN_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | ORN_HUMAN | kinase -> substrate | RegPhos |
| ORN_HUMAN | CDK1_HUMAN | other | KEGG |
| P53_HUMAN | ORN_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03008 | Ribosome biogenesis in eukaryotes |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0004527 | exonuclease activity | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0006139 | nucleobase-containing compound metabolic process | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0009117 | nucleotide metabolic process | TAS | biological_process |