Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ABL1_HUMAN
Description:c-abl oncogene 1, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:76]
Location:chr9 q34.12
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1008TLPSAsSALAGHPRD
S637TPPKRsSSFREHPRD
S828SSPGSsPPNLTHPRD
T613KKTAPtPPKRSPhosphoSitePlus; HPRD
S708EEGGGsSSKRFPhosphoSitePlus
Y393MTGDTyTAHAGABL1RegPhos; SysPTM
T392LMTGDtYTAHAHPRD
S855PVTPTsKAGSGHPRD
S827ESSPGsSPPNLHPRD
Y93LRVLGyNHNGESH3_1PhosphoSitePlus
Y128EKHSWyHGPVSSH2PhosphoSitePlus
Y264GVWKKySLTVAHPRD; phosphoELM; RegPhos
Y139RNAAEyLLSSGSH2PhosphoSitePlus
T392LMTGDtYTAHAPkinase_TyrPhosphoSitePlus
Y469CPEKVyELMRARegPhos
Y393MTGDTyTAHAGAblphosphoELM; SysPTM
T610KKKKKtAPTPPPhosphoSitePlus
S679RESGGsGFRSPPhosphoSitePlus
T267KKYSLtVAVKTPkinase_TyrPhosphoSitePlus
S187GKLYVsSESRFSH2PhosphoSitePlus
S113QGWVPsNYITPSH3_1PhosphoSitePlus
S938PSQSPsQEAAGABL1HPRD
T532ELPTKtRTSRRPhosphoSitePlus
S874PVTPTsKAGSGHPRD
S569HEPAVsPLLPRCDK1HPRD; SysPTM
S977SGTPIsPAPVPF_actin_bindPhosphoSitePlus; SysPTM
Y215ITTLHyPAPKRPhosphoSitePlus
S535TKTRTsRRAAEPhosphoSitePlus
Y393MTGDTyTAHAGautocatalysisRegPhos; SysPTM
S142AEYLLsSGINGSH2PhosphoSitePlus
S618TPPKRsSSFREPhosphoSitePlus; HPRD
T754EWRSVtLPRDLHPRD
S248TVYGVsPNYDKHPRD
T735EWRSVtLPRDLPhosphoSitePlus; HPRD; RegPhos
Y1064AGKNLyTFCVSF_actin_bindPhosphoSitePlus
S620PKRSSsFREMDPhosphoSitePlus; HPRD
Y134WVPSNyITPVNHPRD
Y469CPEKVyELMRASRCRegPhos
S968DAAKPsQPGEGHPRD
Y226NKPTVyGVSPNPhosphoSitePlus; phosphoELM; RegPhos
Y226NKPTVyGVSPNABL1HPRD; RegPhos
T800TRGTVtPPPRLHPRD
T700SSRLAtGEEEGPhosphoSitePlus
Y283GVWKKySLTVAHPRD
S824DIMESsPGSSPHPRD
Y393MTGDTyTAHAGphosphoELM; SysPTM
S934AGGKPsQSPSQHPRD
S977SGTPIsPAPVPHPRD; SysPTM
Y257QYGEVyEGVWKPkinase_TyrPhosphoSitePlus
T814SPPNLtPKPLRPhosphoSitePlus; HPRD
Y456LLEKDyRMERPPkinase_TyrPhosphoSitePlus
Y185SDGKLyVSSESHPRD; phosphoELM; RegPhos
S678ADPAKsPKPSNHPRD
Y257QYGEVyEGVWKHPRD; RegPhos
S919PSQSPsQEAAGPhosphoSitePlus; SysPTM
S465PGIDLsQVYELHPRD
Y393MTGDTyTAHAGSRC_groupRegPhos; SysPTM
T935AKTKAtSLVDAPhosphoSitePlus
Y70LFVALyDFVASSH3_1PhosphoSitePlus
Y172YEGRVyHYRINSH2PhosphoSitePlus
Y412MTGDTyTAHAGSRCHPRD
S917GKPSQsPSQEAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y167SISLRyEGRVYSH2PhosphoSitePlus
T178HYRINtASDGKSH2PhosphoSitePlus
S69AARWNsKENLLHPRD
S569HEPAVsPLLPRCDC2RegPhos; SysPTM
S718FLRSCsASCVPPhosphoSitePlus; HPRD; SysPTM
T117PSNYItPVNSLPhosphoSitePlus
S804KDIMEsSPGSSHPRD
T394TGDTYtAHAGAHPRD; phosphoELM; RegPhos; SysPTM
S683GSGFRsPHLWKPhosphoSitePlus; HPRD; RegPhos; SysPTM
Y393MTGDTyTAHAGSRCHPRD; RegPhos; SysPTM
S569HEPAVsPLLPRPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S919PSQSPsQEAAGABL1HPRD; SysPTM
Y469CPEKVyELMRAABL1HPRD; RegPhos
T781TRGTVtPPPRLPhosphoSitePlus; HPRD; SysPTM
Y393MTGDTyTAHAGSrcRegPhos; SysPTM
T98ASGDNtLSITKHPRD
S989TLPSAsSALAGHPRD
S805DIMESsPGSSPPhosphoSitePlus; HPRD; RegPhos
S915AGGKPsQSPSQHPRD
S943VDAVNsDAAKPPhosphoSitePlus
Y320TEFMTyGNLLDPkinase_TyrPhosphoSitePlus
S446PGIDLsQVYELPkinase_TyrPhosphoSitePlus
T394TGDTYtAHAGAPkinase_TyrPhosphoSitePlus; SysPTM
S955KTKATsLVDAVHPRD
Y276QYGEVyEGVWKHPRD
S619PPKRSsSFREMPhosphoSitePlus
S417AYNKFsIKSDVPkinase_TyrPhosphoSitePlus
T871AAEPVtPTSKAHPRD
T224KRNKPtVYGVSPhosphoSitePlus
S949DAAKPsQPGEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y264GVWKKySLTVAPkinase_TyrPhosphoSitePlus
T1111SGPAAtQDFSKF_actin_bindPhosphoSitePlus
T411LMTGDtYTAHAHPRD
S229TVYGVsPNYDKPhosphoSitePlus; HPRD
S43EPQGLsEAARWPhosphoSitePlus
T735EWRSVtLPRDLTTKphosphoELM
Y115WVPSNyITPVNPhosphoSitePlus; HPRD
S936GKPSQsPSQEAHPRD; SysPTM
S690HLWKKsSTLTSPhosphoSitePlus
Y312REPPFyIITEFPkinase_TyrPhosphoSitePlus
T873EPVTPtSKAGSHPRD
S709EGGGSsSKRFLPhosphoSitePlus
S809SSPGSsPPNLTPhosphoSitePlus; HPRD; RegPhos
Y251GVSPNyDKWEMHPRD
T413TGDTYtAHAGAHPRD
S265VWKKYsLTVAVPkinase_TyrPhosphoSitePlus
S446PGIDLsQVYELHPRD; RegPhos
Y413PESLAyNKFSIPkinase_TyrPhosphoSitePlus
Y204SDGKLyVSSESHPRD
T306LLGVCtREPPFPkinase_TyrPhosphoSitePlus
Y488CPEKVyELMRASRCHPRD
T863GSALGtPAAAEHPRD
S996SGTPIsPAPVPHPRD
T833SPPNLtPKPLRHPRD
Y272LGGGQyGEVYEHPRD
S75YDFVAsGDNTLSH3_1PhosphoSitePlus
T852AAEPVtPTSKAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T632KKTAPtPPKRSHPRD
S936KTKATsLVDAVPhosphoSitePlus; HPRD; SysPTM
Y253LGGGQyGEVYEHPRD; RegPhos
Y185SDGKLyVSSESSH2PhosphoSitePlus
T854EPVTPtSKAGSHPRD; phosphoELM
T389LSRLMtGDTYTPkinase_TyrPhosphoSitePlus
S50AARWNsKENLLPhosphoSitePlus; HPRD; SysPTM
S180RINTAsDGKLYSH2PhosphoSitePlus
S808ESSPGsSPPNLPhosphoSitePlus; HPRD
S446PGIDLsQVYELATMHPRD; phosphoELM; RegPhos
S659ADPAKsPKPSNPhosphoSitePlus; HPRD; SysPTM
T79ASGDNtLSITKHPRD
S729GGGSSsKRFLRHPRD
T844GSALGtPAAAEPhosphoSitePlus; HPRD; phosphoELM
Y232GVSPNyDKWEMPhosphoSitePlus; HPRD
S823KDIMEsSPGSSHPRD
Y469CPEKVyELMRAPkinase_TyrPhosphoSitePlus
Y253LGGGQyGEVYEPkinase_TyrPhosphoSitePlus
S639PKRSSsFREMDHPRD
Y226NKPTVyGVSPNautocatalysisRegPhos
Y174GRVYHyRINTASH2PhosphoSitePlus
Y393MTGDTyTAHAGPkinase_TyrPhosphoSitePlus; SysPTM
S737FLRSCsASCVPHPRD
S588HEPAVsPLLPRCDK1HPRD
S710GGGSSsKRFLRPhosphoSitePlus; HPRD
T692WKKSStLTSSRPhosphoSitePlus
Y226NKPTVyGVSPNSRCRegPhos
S601KTNLFsALIKKPhosphoSitePlus
T243ERTDItMKHKLPkinase_TyrPhosphoSitePlus
S702GSGFRsPHLWKHPRD
Y245NKPTVyGVSPNSRCHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y393RLMTGDTyTAHAGAKPTPN12HPRD
Y412RLMTGDTyTAHAGAKPTPN12HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000323315F311LOMIMchronic myeloid leukemia12130516
ENSP00000323315L248VCOSMICLymphoma15345592
ENSP00000323315G250ECOSMICLymphoma19373669
ENSP00000323315D363GCOSMICLymphoma20038234
ENSP00000323315V299LCOSMICLymphoma21961412
ENSP00000323315G321ECOSMICLymphoma15345592
ENSP00000323315I418VCOSMICLymphoma20697894
ENSP00000323315R166KGreenman2007Skin Cancer17344846, 18428421
ENSP00000323315P1108SCOSMICSkin Cancer21984974
ENSP00000323315E450ACOSMICLymphoma20697894
ENSP00000323315P806LCOSMICLung Cancer18948947
ENSP00000323315A399TCOSMICLymphoma21961412
ENSP00000323315E255KOMIMLeukemia11853795 6297802 12358910 12358910 12663457
ENSP00000323315C330GCOSMICLymphoma19373669
ENSP00000323315L384MCOSMICLymphoma19373669
ENSP00000323315F317LCOSMICLymphoma12623848
ENSP00000361423P825LBIOMARTLung Cancer21930507, 21930502
ENSP00000323315V379ICOSMICLymphoma12204532
ENSP00000323315G677WCOSMICLung Cancer20668451
ENSP00000323315E453LCOSMICLymphoma20697894
ENSP00000323315Q252ECOSMICLymphoma15381060
ENSP00000323315F486SCOSMICLymphoma12623848
ENSP00000323315R732SCOSMICLung Cancer18948947
ENSP00000323315D276GCOSMICLymphoma15345592
ENSP00000323315T315ICOSMICLymphoma19373669
ENSP00000323315L298VCOSMICLymphoma21663510
ENSP00000323315E355GCOSMICLymphoma12623848
ENSP00000323315E373GCOSMICLymphoma15345592
ENSP00000323315N374SCOSMICLymphoma20038234
ENSP00000323315H396RCOSMICLymphoma12623848
ENSP00000323315T495RCOSMICLymphoma19260121
ENSP00000323315T389ACOSMICLymphoma15345592
ENSP00000323315Y253HCOSMICLymphoma15381060
ENSP00000323315R220HCOSMICLymphoma21961412
ENSP00000323315G251DCOSMICLymphoma19625707
ENSP00000323315T823SCOSMICSkin Cancer21984974
ENSP00000323315E279KCOSMICLymphoma19801694
ENSP00000323315E459KCOSMICLymphoma12623848
ENSP00000323315A397PCOSMICLymphoma20697894
ENSP00000323315L370RCOSMICLymphoma19466505
ENSP00000323315L273MCOSMICLymphoma20673586
ENSP00000323315D482VCOSMICLymphoma19625707
ENSP00000323315E255VCOSMICLymphoma19373669
ENSP00000323315S265RCOSMICLymphoma20038234
ENSP00000323315P662LCOSMICGastric Cancer21097718
ENSP00000323315A137SCOSMICLung Cancer20668451
ENSP00000323315M351TOMIMchronic myeloid leukemia12130516
ENSP00000323315V371ACOSMICLymphoma15345592
ENSP00000323315E258VCOSMICLymphoma20038234
ENSP00000323315M351TCOSMICLymphoma15345592
ENSP00000323315T315IOMIMLeukemia11423618 10988075
ENSP00000323315R166KCOSMICMelanoma
ENSP00000323315L364ICOSMICLymphoma19625707
ENSP00000323315C305RCOSMICLymphoma19557636
ENSP00000323315M237ICOSMICLymphoma15345592
ENSP00000323315R47GGreenman2007, COSMICLung Cancer16140923, 17344846, 18428421
ENSP00000323315F311LCOSMICLymphoma12130516
ENSP00000323315F359VCOSMICLymphoma12623848
ENSP00000323315S417YCOSMICLymphoma12623848
ENSP00000323315R328MCOSMICLymphoma19625707
ENSP00000323315M343TCOSMICLymphoma12204532
ENSP00000361423R751SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000361423P825LDing2008Lung Cancer18948947
ENSP00000323315L387MCOSMICLymphoma12204532
ENSP00000323315Q346LCOSMICLymphoma21762985
ENSP00000323315V304GCOSMICLymphoma15345592
ENSP00000323315E352GCOSMICLymphoma15345592
ENSP00000323315D444YCOSMICLymphoma20673586
ENSP00000323315V339LCOSMICLymphoma19557636
ENSP00000323315E292VCOSMICLymphoma19625707
ENSP00000323315I360SCOSMICLymphoma19557636
ENSP00000323315F382LCOSMICLymphoma12204532
ENSP00000323315Q996HBIOMARTBrain Cancer21930507, 21930502
ENSP00000323315Y253HOMIMLeukemia11853795
ENSP00000323315M388LCOSMICLymphoma21895409
ENSP00000323315R47GHPINon-small cell lung carcinoma17344846
ENSP00000323315I242MCOSMICBreast Cancer20668451
ENSP00000323315V289ACOSMICLymphoma21961412
ENSP00000323315P480LCOSMICLymphoma19768693
ENSP00000323315Y353HCOSMICLymphoma15345592
ENSP00000323315K87NCOSMICOvarian Cancer21720365
ENSP00000323315E282KCOSMICLymphoma21961412
ENSP00000323315M244VCOSMICLymphoma12623848
ENSP00000323315A433TCOSMICLymphoma21156844

Differential expressed protein
ABL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y257Pkinase_TyrGGQYGEVyEGVWKKYleukemia17164333PhosphoSitePlus
S446Pkinase_TyrPYPGIDLsQVYELLEataxia-telangiectasia9168116PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ABL1_HUMANWASF2_HUMANkinase -> substrateRegPhos
ABL1_HUMANPLS4_HUMANkinase -> substrateRegPhos
ABL1_HUMANRAD51_HUMANkinase -> substrateRegPhos
ABL1_HUMANGPX1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANPTN6_HUMANkinase -> substrateRegPhos
ABL1_HUMANROBO1_HUMANkinase -> substrateRegPhos
ABL1_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANMDM2_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANRAD9A_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANPLS1_HUMANkinase -> substrateRegPhos
ABL1_HUMANYAP1_HUMANkinase -> substrateHPRD
ABL1_HUMANCRK_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANANXA1_HUMANkinase -> substrateRegPhos
ABL1_HUMANCRKL_HUMANkinase -> substrateRegPhos
ABL1_HUMANGLYAT_HUMANkinase -> substrateRegPhos
ABL1_HUMANJAK2_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANCBL_HUMANkinase -> substrateRegPhos
ABL1_HUMANABL1_HUMANkinase -> substrateRegPhos
ATM_HUMANABL1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANMUC1_HUMANkinase -> substrateRegPhos
SRC_HUMANABL1_HUMANkinase -> substrateRegPhos
ABL1_HUMANIKBA_HUMANkinase -> substrateRegPhos
ABL1_HUMANTAU_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANWASL_HUMANkinase -> substrateRegPhos
ABL1_HUMANCD19_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANJUN_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANBCR_HUMANkinase -> substrateRegPhos
ABL1_HUMANRAD52_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANKPCD1_HUMANkinase -> substrateRegPhos
CDK1_HUMANABL1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANCDN1B_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANP73_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANPPIP1_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANCASP9_HUMANkinase -> substrateHPRD; RegPhos
ABL1_HUMANTOP1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANABL1_HUMANkinase -> substrateRegPhos
ABL1_HUMANCDK5_HUMANkinase -> substrateHPRD; RegPhos
PTN12_HUMANABL1_HUMANphosphatase -> substrateHPRD
CRK_HUMANABL1_HUMANotherKEGG
NCK1_HUMANABL1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa05220Chronic myeloid leukemia
hsa04110Cell cycle
hsa04722Neurotrophin signaling pathway
hsa04360Axon guidance
hsa04012ErbB signaling pathway
hsa05200Pathways in cancer
hsa05416Viral myocarditis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015629actin cytoskeletonTAScellular_component
GO:0006914autophagyIEAbiological_process
GO:2000249regulation of actin cytoskeleton reorganizationTASbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0000115regulation of transcription involved in S phase ofTASbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0008630intrinsic apoptotic signaling pathway in response TASbiological_process
GO:0030155regulation of cell adhesionTASbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:2000145regulation of cell motilityTASbiological_process
GO:0004515nicotinate-nucleotide adenylyltransferase activityTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmTAScellular_component
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0051019mitogen-activated protein kinase bindingIPImolecular_function
GO:0031252cell leading edgeIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003677DNA bindingNASmolecular_function
GO:0030100regulation of endocytosisTASbiological_process
GO:0042692muscle cell differentiationTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0017124SH3 domain bindingIPImolecular_function
GO:0051353positive regulation of oxidoreductase activityIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016301kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006975DNA damage induced protein phosphorylationIDAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0042770signal transduction in response to DNA damageIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0003785actin monomer bindingTASmolecular_function
GO:0006464cellular protein modification processNASbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0030145manganese ion bindingIDAmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0006298mismatch repairTASbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:2001020regulation of response to DNA damage stimulusIDAbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0010506regulation of autophagyTASbiological_process
GO:0071901negative regulation of protein serine/threonine kiIDAbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0030036actin cytoskeleton organizationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0030145manganese ion bindingIEAmolecular_function
GO:0070064proline-rich region bindingIDAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0008022protein C-terminus bindingIPImolecular_function