Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WEE1_HUMAN
Description:WEE1 homolog (S. pombe) [Source:HGNC Symbol;Acc:12761]
Location:chr11 p15.4
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S123GFGSSsPVKSPPhosphoSitePlus; HPRD; RegPhos
T239NINPFtPDSLLPhosphoSitePlus
S642MNRSVsLTBRSK2HPRD
S642MNRSVsLTBRSK1HPRD
S642MNRSVsLTphosphoELM
S123GFGSSsPVKSPCDK1phosphoELM
Y272MEASDyELEDEPhosphoSitePlus
S48EGSGHsTGEDSPhosphoSitePlus
S193PHTPKsLLSKAPhosphoSitePlus
S121EEGFGsSSPVKPhosphoSitePlus; phosphoELM; RegPhos
T49GSGHStGEDSAPhosphoSitePlus
S293ESNMKsRYTTEPhosphoSitePlus
S270EDMEAsDYELEPhosphoSitePlus
Y646VSLTIy_____PhosphoSitePlus
S307LEKIGsGEFGSPkinasePhosphoSitePlus
S471HVTRIsSPQVEHPRD
S642MNRSVsLTIYAKT_groupRegPhos
S165GEGRRsPRPDHPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S123GFGSSsPVKSPCDC2RegPhos
S67LPPARsPTEPGPhosphoSitePlus; HPRD; SysPTM
S137YFLGSsFSPVRPhosphoSitePlus; HPRD
T187LRLFDtPHTPKPhosphoSitePlus; HPRD
S642MNRSVsLTIY_PhosphoSitePlus
S139LGSSFsPVRCGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S150GPGDAsPRGCGPhosphoSitePlus; HPRD; SysPTM
T217SLFMDtEKSGKPhosphoSitePlus
S85GPAPGsPGELEPhosphoSitePlus; HPRD
S212KLRGSsLFMDTPhosphoSitePlus; HPRD; RegPhos
Y258RRKRTyWNDSCPhosphoSitePlus
S78PERRRsPGPAPHPRD
S53STGEDsAFQEPPLK1HPRD; phosphoELM; RegPhos
Y132SPAAPyFLGSSPhosphoSitePlus; HPRD
T173PDHPGtPPHKTPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S642MNRSVsLTIYBRSK2RegPhos
S642MNRSVsLTIYBRSK1RegPhos
S53STGEDsAFQEPPhosphoSitePlus
S127SSPVKsPAAPYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S312SGEFGsVFKCVPkinasePhosphoSitePlus; SysPTM
T69PARSPtEPGPEPhosphoSitePlus
S312SGEFGsVFKCVHPRD; SysPTM
S211VKLRGsSLFMDPhosphoSitePlus; HPRD; RegPhos
S123GFGSSsPVKSPCDC2(CDK1RegPhos
S559PERRPsAMALVHPRD; RegPhos
S136PYFLGsSFSPVHPRD
T173PDHPGtPPHKTWEE1HPRD; SysPTM
T190FDTPHtPKSLLPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
WEE1_HUMAN do not have dephosphorylation site.

Mutation site
WEE1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000402084Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp515169874

Hyperphosphorylation site
WEE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
WEE1_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANENOA_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZN671_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSPF45_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANWEE1_HUMANkinase -> substrateRegPhos
WEE1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCENPS_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMTA70_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCDK2_HUMANkinase -> substrateHPRD
WEE1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANDDX4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANXRCC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
BRSK2_HUMANWEE1_HUMANkinase -> substrateHPRD; RegPhos
WEE1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZ280D_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCDK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
WEE1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANEVX1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCDKA1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANKCC1D_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANLRIG1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANDX39A_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANVHL_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANTAGL2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSPN1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANIF4A3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANHSFX1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANUBB_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANFAP24_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANPHB2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZMYM3_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANWEE1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
WEE1_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANS10AB_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZBTB4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNU107_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
BRSK1_HUMANWEE1_HUMANkinase -> substrateHPRD; RegPhos
WEE1_HUMANT22D4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANBRSK2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANWEE1_HUMANkinase -> substrateHPRD
WEE1_HUMANSF3B1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANWEE1_HUMANkinase -> substrateRegPhos
WEE1_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
FOS_HUMANWEE1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000075cell cycle checkpointTASbiological_process
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0048812neuron projection morphogenesisIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0051726regulation of cell cycleTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0030010establishment of cell polarityIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0007067mitosisIEAbiological_process