Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LMNB1_HUMAN
Description:lamin B1 [Source:HGNC Symbol;Acc:6637]
Location:chr5 q23.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S375LDMEIsAYRKLFilamentPhosphoSitePlus
T5_MATAtPVPPRPhosphoSitePlus
S396SPSPSsRVTVSPhosphoSitePlus; HPRD
T283SSEMNtSTVNSFilament; Atg14; Spc7PhosphoSitePlus
Y268ELEQTyHAKLEFilament; Atg14; Spc7PhosphoSitePlus
Y46DRLAVyIDKVRIncA; Filament; DUF869; MPhosphoSitePlus
S375LDMEIsAYRKLHPRD
S304RIESLsSQLSNFilament; Atg14; Spc7PhosphoSitePlus
S23PTTPLsPTRLSCDC2RegPhos; SysPTM
S391ERLKLsPSPSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S406SRASSsRSVRTPhosphoSitePlus
S396SPSPSsRVTVSPKC_groupphosphoELM; RegPhos
S395LSPSPsSRVTVPKCb(PKC betaRegPhos
S406SRASSsRSVRTPKC_groupphosphoELM; RegPhos
T5VPPRHPRD
S210LEFRKsMYEEEHPRD
T412RSVRTtRGKRKPhosphoSitePlus
S23PTTPLsPTRLSHPRD; phosphoELM; RegPhos; SysPTM
S404TVSRAsSSRSVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y212FRKSMyEEEINFilament; DUF869; Spc7; MPhosphoSitePlus
T340SRRMLtDKEREFilament; Atg14; Spc7PhosphoSitePlus
S28SPTRLsRLQEKHPRD; phosphoELM; RegPhos
S401SRVTVsRASSSPhosphoSitePlus
T267EELEQtYHAKLFilament; Myosin_tail_1; PhosphoSitePlus
S232LVEVDsGRQIEHPRD
S284SEMNTsTVNSAHPRD
S279NARLSsEMNTSHPRD
S232LVEVDsGRQIEFilament; Myosin_tail_1PhosphoSitePlus
T19RAGGPtTPLSPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S395LSPSPsSRVTVPKCbRegPhos
T25TPLSPtRLSRLIncAPhosphoSitePlus
T20AGGPTtPLSPTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S395LSPSPsSRVTVPhosphoSitePlus
S405VSRASsSRSVRPhosphoSitePlus
T25TPLSPtRLSRLHPRD; phosphoELM; RegPhos
S405VSRASsSRSVRPKCb(PKC betaRegPhos
T285EMNTStVNSARFilament; Atg14; Spc7PhosphoSitePlus
S393LKLSPsPSSRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T399PSSRVtVSRASPhosphoSitePlus
S23PTTPLsPTRLSIncAPhosphoSitePlus; SysPTM
S579GTPRAsNRSCAHPRD
S405VSRASsSRSVRPKCbRegPhos
S302RMRIEsLSSQLFilament; Atg14; Spc7PhosphoSitePlus
S288TSTVNsAREELFilament; Atg14; Spc7PhosphoSitePlus
S405VSRASsSRSVRPKC_betaphosphoELM
S284SEMNTsTVNSAFilament; Atg14; Spc7PhosphoSitePlus
S395LSPSPsSRVTVPKC_betaphosphoELM
Y138IKLREyEAALNIncA; Filament; Myosin_taPhosphoSitePlus
T3TPVPHPRD
S158LGDKKsLEGDLHPRD
T575FHQQGtPRASNPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S405VSRASsSRSVRPRKCBHPRD
T411SRSVRtTRGKRPhosphoSitePlus
Y360QQLNDyEQLLDFilament; Atg14; Spc7PhosphoSitePlus
S200ENRCQsLTEDLFilament; DUF869; Spc7; MPhosphoSitePlus; SysPTM
S305IESLSsQLSNLFilament; Atg14; Spc7PhosphoSitePlus
S200ENRCQsLTEDLHPRD; phosphoELM; RegPhos; SysPTM
S158LGDKKsLEGDLIncA; Filament; DUF869; SPhosphoSitePlus
S278ENARLsSEMNTHPRD
S23PTTPLsPTRLSCDK1HPRD; SysPTM
S534VILKNsQGEEVLTDPhosphoSitePlus
S13PPRMGsRAGGPPhosphoSitePlus; RegPhos
T3___MAtATPVPPhosphoSitePlus
S395LSPSPsSRVTVPRKCBHPRD
S210LEFRKsMYEEEFilament; DUF869; Spc7; MPhosphoSitePlus
S23PTTPLsPTRLSCDK_groupphosphoELM; RegPhos; SysPTM
S408ASSSRsVRTTRPhosphoSitePlus
S393LKLSPsPSSRVCDK_groupphosphoELM; RegPhos

Dephosphorylation site
LMNB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261366E69KCOSMICCentral Nervous System Neoplasms18772396
ENSP00000261366T202ICOSMICHead and Neck Cancer21798893
ENSP00000261366E567GCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261366Breast CancerNormal vs. CancertissueDown0.6712096126
ENSP00000261366Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000261366Hepatocellular CarcinomaNormal vs. CancertissueUp3.311866469
ENSP00000261366hepatitis B virusNormal vs. CancertissueUp4.814654528
ENSP00000261366hepatitis C virusNormal vs. CancertissueUp216097030
ENSP00000261366Hepatocellular CarcinomaNormal vs. CancertissueUp18937283
ENSP00000261366acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000261366acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000261366Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.2115169874
ENSP00000261366Renal CancerNormal vs. CancertissueUp3.4-6.4 12923786
ENSP00000261366Testicular CancerNormal vs. Cancercell lineDown18489135
ENSP00000261366Uterine CancerTreatment (Concurrent chemoradiotherapy-lowly vs. Concurrent chemoradiotherapy-highly sensitive)tissueDown19507834
ENSP00000261366Hepatocellular CarcinomaNormal vs. CancertissueUp211866469

Hyperphosphorylation site
LMNB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANLMNB1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANLMNB1_HUMANkinase -> substrateRegPhos
CDK1_HUMANLMNB1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
LMNB1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005198structural molecule activityIEAmolecular_function
GO:0005635nuclear envelopeIEAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0043274phospholipase bindingIEAmolecular_function
GO:0005638lamin filamentIEAcellular_component
GO:0005654nucleoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0005637nuclear inner membraneIEAcellular_component


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