Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTHR_HUMAN
Description:parathyroid hormone-like hormone [Source:HGNC Symbol;Acc:9607]
Location:chr12 p11.22
Node attribute:substrate; ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T108YLTQEtNKVETCDK2HPRD; RegPhos
T108YLTQEtNKVETParathyroid; Herpes_DNAp_PhosphoSitePlus
T108YLTQEtNKVETCDK1phosphoELM
T121EQPLKtPGKKKParathyroid; Herpes_DNAp_PhosphoSitePlus
T113TNKVEtYKEQPParathyroid; Herpes_DNAp_PhosphoSitePlus
S31SVEGLsRRLKRPhosphoSitePlus
T108YLTQEtNKVETCDC2(CDK1RegPhos

Dephosphorylation site
PTHR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379209S169TBIOMARTBreast Cancer21930507, 21930502
ENSP00000379213S169THPIBreast Cancer16959974
ENSP00000201015S169TSjoblom2006, COSMICBreast Cancer16959974

Differential expressed protein
PTHR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTHR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTHR_HUMANPTH1R_HUMANligand -> receptorHPMR
CDK2_HUMANPTHR_HUMANkinase -> substrateHPRD; RegPhos
CDK1_HUMANPTHR_HUMANkinase -> substrateRegPhos
SMAD3_HUMANPTHR_HUMANTF -> target geneTRANSFAC
SP1_HUMANPTHR_HUMANTF -> target geneTRANSFAC
ETS1_HUMANPTHR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PTHR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0010468regulation of gene expressionIDAbiological_process
GO:0046058cAMP metabolic processTASbiological_process
GO:0016485protein processingIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0007565female pregnancyTASbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0001501skeletal system developmentIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIEAbiological_process
GO:0051428peptide hormone receptor bindingIDAmolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0007267cell-cell signalingTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007492endoderm developmentIEAbiological_process
GO:0001958endochondral ossificationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005179hormone activityIEAmolecular_function
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0001501skeletal system developmentIDAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIDAbiological_process
GO:0060659nipple sheath formationIEAbiological_process
GO:0032331negative regulation of chondrocyte differentiationIEAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0043129surfactant homeostasisIEAbiological_process
GO:0008544epidermis developmentTASbiological_process
GO:0005615extracellular spaceTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0048286lung alveolus developmentIEAbiological_process
GO:0060649mammary gland bud elongationIEAbiological_process


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