Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PO210_HUMAN
Description:nucleoporin 210kDa [Source:HGNC Symbol;Acc:30052]
Location:chr3 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1874PARKAsPPSGLPhosphoSitePlus; HPRD; phosphoELM
S1877KASPPsGLWSPPhosphoSitePlus; HPRD
S209DTILVsGMKTGPhosphoSitePlus
S869QESHLsSARTKHPRD
S1881PSGLWsPAYAphosphoELM
S1863ASSPTsPNALPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1848LTPRAsPGHSPPhosphoSitePlus; HPRD; phosphoELM
T1844VPAALtPRASPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1860YFAASsPTSPNPhosphoSitePlus; HPRD; phosphoELM
Y937VVKVAyQEARGPhosphoSitePlus
Y1884LWSPAyAHPRD; phosphoELM
Y1884LWSPAyASH__PhosphoSitePlus
S1727EVKSGsPAVLAPhosphoSitePlus
S1886SPAYAsH____PhosphoSitePlus
S1852ASPGHsPHYFAPhosphoSitePlus; HPRD; phosphoELM
S1859HYFAAsSPTSPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1881PSGLWsPAYACDK1HPRD
Y1855GHSPHyFAASSPhosphoSitePlus; HPRD
S1881PSGLWsPAYASCDC2RegPhos
S649KAVDPsSVALVHPRD
S659VTLGSsKEMLFHPRD
T504VKGVMtTGSDIPhosphoSitePlus
S866TGYQEsHLSSAHPRD
T505KGVMTtGSDIGPhosphoSitePlus
S1886SPAYAHPRD; phosphoELM
S1881PSGLWsPAYASPhosphoSitePlus; RegPhos
T1862AASSPtSPNALphosphoELM
Y1268TSGQLyGLAREPhosphoSitePlus

Dephosphorylation site
PO210_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254508D1805YCOSMICOvarian Cancer21720365
ENSP00000254508P134LCOSMICSkin Cancer21984974
ENSP00000254508A394SCOSMICOvarian Cancer21720365
ENSP00000254508F678LCOSMICHead and Neck Cancer21798893
ENSP00000254508V1581MCOSMICHepatocellular Carcinoma
ENSP00000254508E1606QCOSMICOvarian Cancer21720365
ENSP00000254508S308LCOSMICIntestines Cancer17932254
ENSP00000254508R984HCOSMICIntestines Cancer17932254
ENSP00000254508K1872*COSMICOvarian Cancer21720365
ENSP00000254508V1579FCOSMICOvarian Cancer21720365
ENSP00000254508A1819PCOSMICHead and Neck Cancer21798893
ENSP00000254508V724MCOSMICSkin Cancer21984974
ENSP00000254508A1147TCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000254508Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.4816319398

Hyperphosphorylation site
PO210_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANPO210_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANPO210_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005635nuclear envelopeTAScellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0015758glucose transportTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0010827regulation of glucose transportTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0008645hexose transportTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005635nuclear envelopeIEAcellular_component
GO:0005643nuclear poreIEAcellular_component
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0046983protein dimerization activityIEAmolecular_function
GO:0015031protein transportIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0051028mRNA transportIEAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0016032viral reproductionTASbiological_process


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