Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LMNA_HUMAN
Description:lamin A/C [Source:HGNC Symbol;Acc:6636]
Location:chr1 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T19AQASStPLSPTIncAPhosphoSitePlus
S403SRGRAsSHSSQDUF3584PhosphoSitePlus
S22SSTPLsPTRITCDK_groupphosphoELM; RegPhos
T590TVLCGtCGQPAPhosphoSitePlus
S66LRITEsEEVVSIncA; Filament; DUF869; MPhosphoSitePlus
T416GGGSVtKKRKLPhosphoSitePlus; HPRD; RegPhos
S392LRLSPsPTSQRDUF3584; IncAPhosphoSitePlus
S423KRKLEsTESRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S612VGGPIsSGSSAHPRD
T19AQASStPLSPTCDC2RegPhos
S618SGSSAsSVTVTPhosphoSitePlus; HPRD
S431SRSSFsQHARTHPRD
T480DDPLLtYRFPPPKC_groupphosphoELM; RegPhos
S301RIRIDsLSAQLFilament; Myosin_tail_1; PhosphoSitePlus
T24TPLSPtRITRLIncA; DUF869; Myosin_tailPhosphoSitePlus
S390ERLRLsPSPTSHPRD; phosphoELM; RegPhos
S615PISSGsSASSVHPRD; phosphoELM
S12RRATRsGAQASIncAPhosphoSitePlus
T3___MEtPSQRRPhosphoSitePlus
T64LRLRItESEEVIncA; Filament; DUF869; MPhosphoSitePlus
S403SRGRAsSHSSQphosphoELM; RegPhos
S463SNEDQsMGNWQLTDPhosphoSitePlus
T416GGGSVtKKRKLPKC_groupphosphoELM; RegPhos
S277DNARQsAERNSHPRD; phosphoELM; RegPhos
S613GGPISsGSSASPhosphoSitePlus; HPRD; phosphoELM
S403SRGRAsSHSSQPKCaRegPhos
S525WGCGNsLRTALPRKCAHPRD
T10SQRRAtRSGAQHPRD; phosphoELM; RegPhos
S426LESTEsRSSFSPhosphoSitePlus; HPRD
S94RKTLDsVAKERHPRD
S71SEEVVsREVSGIncA; Filament; DUF869; MPhosphoSitePlus
S595VTVTRsYRSVGHPRD
S533TALINsTGEEVLTDPhosphoSitePlus
T19AQASStPLSPTPRKCAHPRD
S212QKNIYsEELREFilament; Myosin_tail_1; PhosphoSitePlus
T409SHSSQtQGGGSDUF3584PhosphoSitePlus
S404RGRASsHSSQTPKCaRegPhos
T3SQRRHPRD
S598TRSYRsVGGSGHPRD
S18GAQASsTPLSPIncAPhosphoSitePlus
S525WGCGNsLRTALPKCaRegPhos
S406RASSHsSQTQGDUF3584PhosphoSitePlus
S107LQLELsKVREEHPRD
T409SHSSQtQGGGSHPRD; phosphoELM; RegPhos
S585PISSGsSASSVHPRD
T19AQASStPLSPTHPRD; phosphoELM; RegPhos
S404RGRASsHSSQTPRKCAHPRD
T505AGAGAtHSPPTLTDPhosphoSitePlus
T19AQASStPLSPTCDK1HPRD
S392LRLSPsPTSQRCDK1HPRD
S533TALINsTGEEVHPRD
S307LSAQLsQLQKQFilament; Myosin_tail_1; PhosphoSitePlus
S406RASSHsSQTQGHPRD; phosphoELM; RegPhos
S568HHHHVsGSHPRD
S588SGSSAsSVTVTHPRD
S429TESRSsFSQHALTDPhosphoSitePlus
S22SSTPLsPTRITCDC2RegPhos
S392LRLSPsPTSQRHPRD; phosphoELM; RegPhos
S66LRITEsEEVVSHPRD
S431SRSSFsQHARTLTDPhosphoSitePlus
S525WGCGNsLRTALLTDPhosphoSitePlus
S404RGRASsHSSQTPKC_groupphosphoELM; RegPhos
S525WGCGNsLRTALphosphoELM; RegPhos
S463SNEDQsMGNWQHPRD
S51IDRVRsLETENHPRD
S404RGRASsHSSQTRegPhos
S392LRLSPsPTSQRCDC2RegPhos
T424RKLEStESRSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T24TPLSPtRITRLHPRD
S398PTSQRsRGRASHPRD; phosphoELM
T548LVRSVtVVEDDLTDPhosphoSitePlus
S628TRSYRsVGGSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S51IDRVRsLETENIncA; Filament; DUF869; MPhosphoSitePlus
S5RRATPKC_groupphosphoELM
S18GAQASsTPLSPHPRD; phosphoELM
S622LLGNSsPRTQSHPRD
T64LRLRItESEEVHPRD
T613GDNLVtRSYLLHPRD
T510THSPPtDLVWKRegPhos
S657SPRTQsPQNCSPhosphoSitePlus
S395SPSPTsQRSRGHPRD; phosphoELM; RegPhos
S414TQGGGsVTKKRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y81GIKAAyEAELGIncA; Filament; DUF869; MPhosphoSitePlus
S212QKNIYsEELREHPRD
S94RKTLDsVAKERIncA; Filament; DUF869; MPhosphoSitePlus
S12RRATRsGAQASHPRD; phosphoELM; RegPhos
S616ISSGSsASSVTPhosphoSitePlus; HPRD; phosphoELM
S303RIDSLsAQLSQFilament; Myosin_tail_1; PhosphoSitePlus
S586ISSGSsASSVTHPRD
S583EYNLRsRTVLCPhosphoSitePlus
S22SSTPLsPTRITCDK1HPRD
S625VTVTRsYRSVGHPRD
T19AQASStPLSPTPKCaRegPhos
S407ASSHSsQTQGGDUF3584PhosphoSitePlus
T199ENRLQtMKEELPKC_groupphosphoELM; RegPhos
T505AGAGAtHSPPTHPRD; RegPhos
S71SEEVVsREVSGHPRD
T585NLRSRtVLCGTPhosphoSitePlus
S636GSGGGsFGDNLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S458RLRNKsNEDQSLTDPhosphoSitePlus
S428STESRsSFSQHHPRD
S546RKLVRsVTVVELTDPhosphoSitePlus
S407ASSHSsQTQGGHPRD; phosphoELM; RegPhos
S22SSTPLsPTRITHPRD; phosphoELM; RegPhos
S583GGPISsGSSASHPRD
S301RIRIDsLSAQLHPRD; phosphoELM
T534ALINStGEEVAHPRD
T224KRRHEtRLVEIFilament; Myosin_tail_1; PhosphoSitePlus
S652LLGNSsPRTQSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S395SPSPTsQRSRGDUF3584; IncAPhosphoSitePlus
T394LSPSPtSQRSRHPRD; phosphoELM
T19AQASStPLSPTCDK_groupphosphoELM; RegPhos
S17SGAQAsSTPLSIncAPhosphoSitePlus
S625VTVTRsYRSVGPKC_groupphosphoELM; RegPhos
S507AGATHsPPTDLRegPhos
S282SAERNsNLVGAHPRD
S398PTSQRsRGRASDUF3584; IncAPhosphoSitePlus
T496AGQVVtIWAAGRegPhos
S458RLRNKsNEDQSHPRD; phosphoELM
T10SQRRAtRSGAQIncAPhosphoSitePlus
T394LSPSPtSQRSRDUF3584; IncAPhosphoSitePlus
S589GSSASsVTVTRHPRD
S17SGAQAsSTPLSHPRD
S403SRGRAsSHSSQPRKCAHPRD
S606GSGGGsFGDNLHPRD
S619GSSASsVTVTRHPRD; phosphoELM
S403SRGRAsSHSSQPKC_groupphosphoELM; RegPhos
S404RGRASsHSSQTDUF3584PhosphoSitePlus
S570HHVSGsHPRD
S429TESRSsFSQHAHPRD
S277DNARQsAERNSFilament; Myosin_tail_1; PhosphoSitePlus
S22SSTPLsPTRITIncA; Myosin_tail_1PhosphoSitePlus
S5METPSqRRATPKC_groupRegPhos
S390ERLRLsPSPTSDUF3584; IncAPhosphoSitePlus
S602RSVGGsGGGSFHPRD
S107LQLELsKVREEIncA; Filament; DUF869; MPhosphoSitePlus
S632RSVGGsGGGSFPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T643GDNLVtRSYLLHPRD
S582VGGPIsSGSSAHPRD

Dephosphorylation site
LMNA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355292D272YBIOMARTBreast Cancer21930507, 21930502
ENSP00000357283D272YBIOMARTBreast Cancer21930507, 21930502
ENSP00000357283V256GCOSMICOvarian Cancer21720365
ENSP00000357283N580KCOSMICOvarian Cancer21720365
ENSP00000292304D272YBIOMARTBreast Cancer21930507, 21930502
ENSP00000357283I210VCOSMICOvarian Cancer21720365
ENSP00000357284D272YBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000357283Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.3218646787
ENSP00000357283Breast CancerTreatment (none vs. SEL1L treatment)cell lineUp3.215880780
ENSP00000357283Gastric CancerMetastasiscell lineUp2.117022644
ENSP00000357283colorectal cancerNormal vs. CancertissueUp1.619098285
ENSP00000357283Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineDown0.8117152098
ENSP00000357283Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000357283Hepatocellular CarcinomaNormal vs. CancertissueUp2.817627933
ENSP00000357283follicular thyroid carcinomaNormal vs. CancertissueDown0.7518316623
ENSP00000357283Esophageal CancerNormal vs. CancertissueDown0.1619142970
ENSP00000357283Esophageal CancerNormal vs. CancertissueDown0.2319142970
ENSP00000357283Esophageal CancerNormal vs. CancertissueDown0.2919142970
ENSP00000357283MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.4917854218
ENSP00000357283Hepatocellular CarcinomaMetastasiscell lineUp1.719016532
ENSP00000357283Hepatocellular CarcinomaCancer vs. CancertissueUp20038311
ENSP00000357283Non-small cell lung carcinomaTreatment (none vs. anticancer drug CPT and 10-OH treatment??cell lineDown0.3617009856
ENSP00000357283Lung CancerTreatment(none vs 20 mg/mL GTE treatment)cell lineUp2.419137550
ENSP00000357283Lung CancerTreatment(none vs 40 mg/mL GTE treatment)cell lineUp3.519137550
ENSP00000357283Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineUp19795389
ENSP00000357283Gastric CancerMetastasiscell lineUp2.117022644
ENSP00000357283Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp2.118253933
ENSP00000357283Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueDown0.2218830628
ENSP00000357283Breast CancerNormal vs. CancertissueDown0.8820857901
ENSP00000357283Breast CancerNormal vs. CancertissueDown0.3420857901
ENSP00000357283Breast CancerNormal vs. CancertissueUp2.620857901
ENSP00000357283breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000357283acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000357283NonmelanomaNormal vs. Cancercell lineDown0.6519243805
ENSP00000357283Ovarian CancerMetastasiscell lineDown17892554
ENSP00000357283Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.218973835
ENSP00000357283Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.518973835
ENSP00000357283Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7719714814
ENSP00000357283Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.219714814
ENSP00000357283Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1.319714814
ENSP00000357283Gastric CancerTreatment (none vs. drug-resistant)cell lineDown0.6120625496
ENSP00000357283Biliary Tract CancerMetastasiscell lineDown0.2919299076
ENSP00000357283Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp219513556
ENSP00000357283Pancreatic CancerTreatment (none vs. IL-1 treatment)cell lineUp3.519513556

Hyperphosphorylation site
LMNA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANLMNA_HUMANkinase -> substrateRegPhos
CDK1_HUMANLMNA_HUMANkinase -> substrateRegPhos
KPCA_HUMANLMNA_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030951establishment or maintenance of microtubule cytoskISSbiological_process
GO:0005635nuclear envelopeIEAcellular_component
GO:0030951establishment or maintenance of microtubule cytoskIEAbiological_process
GO:0007517muscle organ developmentIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0034504protein localization to nucleusIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005638lamin filamentIEAcellular_component
GO:0005882intermediate filamentTAScellular_component
GO:0030334regulation of cell migrationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0034504protein localization to nucleusISSbiological_process
GO:0005652nuclear laminaTAScellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0042981regulation of apoptotic processISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0055015ventricular cardiac muscle cell developmentIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0005635nuclear envelopeIDAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0006997nucleus organizationIEAbiological_process
GO:0035105sterol regulatory element binding protein import iIEAbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0090343positive regulation of cell agingIDAbiological_process
GO:0030334regulation of cell migrationISSbiological_process
GO:0006998nuclear envelope organizationIEAbiological_process