Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDX3X_HUMAN
Description:DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked [Source:HGNC Symbol;Acc:2745]
Location:chrX p11.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S102DDRGRsDYDGIPhosphoSitePlus; HPRD; SysPTM
Y462LEDFLyHEGYAHelicase_CPhosphoSitePlus
S492FRSGKsPILVAHelicase_CPhosphoSitePlus
S71KDAYSsFGSRSPhosphoSitePlus
T204RYTRPtPVQKHDEADPhosphoSitePlus
Y163INFEKyDDIPVPhosphoSitePlus
T323HLLVAtPGRLVDEADPhosphoSitePlus
S82DSRGKsSFFSDPhosphoSitePlus; HPRD
S614SSSSFsSSRASPhosphoSitePlus; SysPTM
S92DRGSGsRGRFDPhosphoSitePlus; HPRD
S131RWCDKsDEDDWPhosphoSitePlus
S90FSDRGsGSRGRPhosphoSitePlus
Y652GYGGNyNSQGVPhosphoSitePlus
Y104RGRSDyDGIGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S109YDGIGsRGDRSPhosphoSitePlus
T438DLLNAtGKDSLPhosphoSitePlus
S78GSRSDsRGKSSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S57FYDKDsSGWSSHPRD
Y260KENGRyGRRKQDEADPhosphoSitePlus
S619SSSRAsSSRSGPhosphoSitePlus
S83SRGKSsFFSDRPhosphoSitePlus; HPRD
S86KSSFFsDRGSGPhosphoSitePlus
Y466LYHEGyACTSIHelicase_CPhosphoSitePlus
S76SFGSRsDSRGKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T204RYTRPtPVQKHCDC2(CDK1RegPhos
T323HLLVAtPGRLVHPRD
S616SSFSSsRASSSPhosphoSitePlus
S594KSSRFsGGFGAPhosphoSitePlus; HPRD; RegPhos; SysPTM
S23GLDLNsSDNQSHPRD
Y301RPCVVyGGADIDEADPhosphoSitePlus
Y602FGARDyRQSSGPhosphoSitePlus
Y266GRRKQyPISLVDEADPhosphoSitePlus
Y53ATKGFyDKDSSPhosphoSitePlus
Y69KDKDAySSFGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T323HLLVAtPGRLVCDC2(CDK1RegPhos
Y243ILSQIySDGPGDEADPhosphoSitePlus
S612GASSSsFSSSRPhosphoSitePlus; HPRD; SysPTM
S590RGRSKsSRFSGHPRD; RegPhos
S58YDKDSsGWSSSHPRD
S62SSGWSsSKDKDPhosphoSitePlus; HPRD
S456KKGADsLEDFLPhosphoSitePlus
S591GRSKSsRFSGGPhosphoSitePlus
S61DSSGWsSSKDKPhosphoSitePlus; HPRD
S606DYRQSsGASSSPhosphoSitePlus
S611SGASSsSFSSSphosphoELM
S520NFDLPsDIEEYHelicase_CPhosphoSitePlus
S74YSSFGsRSDSRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S70DKDAYsSFGSRPhosphoSitePlus
S605RDYRQsSGASSPhosphoSitePlus
S63SGWSSsKDKDAPhosphoSitePlus; HPRD
T204RYTRPtPVQKHHPRD
Y343LDFCKyLVLDEHPRD; phosphoELM; RegPhos
T323HLLVAtPGRLVCDK1phosphoELM
T204RYTRPtPVQKHCDK1phosphoELM
Y283LAVQIyEEARKDEADPhosphoSitePlus
Y343LDFCKyLVLDEDEADPhosphoSitePlus
Y639FGGGGyGGFYNPhosphoSitePlus
S615SSSFSsSRASSPhosphoSitePlus
S125ERGGNsRWCDKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
DDX3X_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382840*663GCOSMICHead and Neck Cancer21798893
ENSP00000382840R407TCOSMICHead and Neck Cancer21798893
ENSP00000382840R326CBIOMARTBrain Cancer21930507, 21930502
ENSP00000382840R376SBIOMARTBrain Cancer21930507, 21930502
ENSP00000382840D455YBIOMARTBreast Cancer21930507, 21930502
ENSP00000382840R548TCOSMICOvarian Cancer21720365
ENSP00000382840H527YBIOMARTBrain Cancer21930507, 21930502
ENSP00000382840P371SCOSMICHead and Neck Cancer21798893
ENSP00000382840E424*COSMICHead and Neck Cancer21798893
ENSP00000382840R548TTCGAOvarian Cancer21720365, 18772890
ENSP00000382840G154DCOSMICSkin Cancer21984974
ENSP00000382840N551HTCGAOvarian Cancer21720365, 18772890
ENSP00000382840F234LCOSMICCentral Nervous System Neoplasms21163964
ENSP00000382840E449*BIOMARTBreast Cancer21930507, 21930502
ENSP00000382840A502TCOSMICMelanoma
ENSP00000382840R475CBIOMARTBrain Cancer21930507, 21930502
ENSP00000382840N551HCOSMICOvarian Cancer21720365
ENSP00000382840R534SBIOMARTBrain Cancer21930507, 21930502
ENSP00000382840D354GBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000382840R294THPI, COSMICBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000382840Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4518646787
ENSP00000382840Prostate CancerMetastasiscell lineDown0.2915102926
ENSP00000382840Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217
ENSP00000382840Breast CancerNormal vs. CancertissueUp0.4720739354
ENSP00000382840Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000382840Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.620625496

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y104DDRGRSDyDGIGSRGcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANDDX3X_HUMANkinase -> substrateRegPhos
CDK1_HUMANDDX3X_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04622RIG-I-like receptor signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0042256mature ribosome assemblyIMPbiological_process
GO:0035613RNA stem-loop bindingIDAmolecular_function
GO:0048027mRNA 5'-UTR bindingIDAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005852eukaryotic translation initiation factor 3 complexIDAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0004386helicase activityIEAmolecular_function
GO:2001243negative regulation of intrinsic apoptotic signaliIMPbiological_process
GO:0032728positive regulation of interferon-beta productionTASbiological_process
GO:0010501RNA secondary structure unwindingIDAbiological_process
GO:0045727positive regulation of translationIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0017148negative regulation of translationIMPbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0071651positive regulation of chemokine (C-C motif) liganTASbiological_process
GO:0043024ribosomal small subunit bindingIDAmolecular_function
GO:0007059chromosome segregationIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003723RNA bindingIDAmolecular_function
GO:0008143poly(A) RNA bindingIDAmolecular_function
GO:1900087positive regulation of G1/S transition of mitotic IMPbiological_process
GO:0045948positive regulation of translational initiationIMPbiological_process
GO:0071470cellular response to osmotic stressIDAbiological_process
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0034063stress granule assemblyIDAbiological_process
GO:0008625extrinsic apoptotic signaling pathway via death doIMPbiological_process
GO:0004004ATP-dependent RNA helicase activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0031333negative regulation of protein complex assemblyIDAbiological_process
GO:0008190eukaryotic initiation factor 4E bindingIDAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045087innate immune responseIMPbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0097193intrinsic apoptotic signaling pathwayIMPbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0009615response to virusIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0010494cytoplasmic stress granuleIDAcellular_component
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0031369translation initiation factor bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0071243cellular response to arsenic-containing substanceIDAbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIMPbiological_process
GO:0008134transcription factor bindingIDAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0016607nuclear speckIEAcellular_component
GO:0030307positive regulation of cell growthIMPbiological_process
GO:0022627cytosolic small ribosomal subunitIDAcellular_component
GO:0016887ATPase activityIDAmolecular_function