| UniProt/SwissProt ID: | RAB5B_HUMAN |
| Description: | RAB5B, member RAS oncogene family [Source:HGNC Symbol;Acc:9784] |
| Location: | chr12 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y82 | AGQERyHSLAP | Ras | PhosphoSitePlus |
| S123 | LQRQAsPSIVI | Ras | PhosphoSitePlus |
| S123 | LQRQAsPSIVI | CDC2(CDK1 | RegPhos |
| S123 | LQRQAsPSIVI | CDC2 | RegPhos |
| S123 | LQRQAsPSIVI | CDK1 | HPRD; phosphoELM |
| S84 | QERYHsLAPMY | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RAB5B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RAB5B_HUMAN do not have mutation site. |
| Differential expressed protein |
| RAB5B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RAB5B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK2_HUMAN | RAB5B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | RAB5B_HUMAN | kinase -> substrate | HPRD; RegPhos |
| KS6B1_HUMAN | RAB5B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04145 | Phagosome |
| hsa05146 | Amoebiasis |
| hsa05152 | Tuberculosis |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0030139 | endocytic vesicle | IEA | cellular_component |
| GO:0030100 | regulation of endocytosis | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0030742 | GTP-dependent protein binding | IDA | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005768 | endosome | IDA | cellular_component |
| GO:0007032 | endosome organization | IEA | biological_process |
| GO:0042470 | melanosome | IEA | cellular_component |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0003924 | GTPase activity | TAS | molecular_function |