Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:APLP2_HUMAN
Description:amyloid beta (A4) precursor-like protein 2 [Source:HGNC Symbol;Acc:598]
Location:chr11 q24.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T723KRQYGtISHGIPKC_groupphosphoELM; RegPhos
T723KRQYGtISHGIAPP_amyloidPhosphoSitePlus
T754GYENPtYKYLEAPP_amyloidPhosphoSitePlus
T736VDPMLtPEERHMAPK8phosphoELM
T303SDKEItHDVKAPhosphoSitePlus; HPRD
T736VDPMLtPEERHCDK1HPRD; phosphoELM
T736VDPMLtPEERHCDC2RegPhos
S213IIGSVsKEEEEPhosphoSitePlus; HPRD
T736VDPMLtPEERHCDC2(CDK1RegPhos
T723KRQYGtISHGIPRKCAHPRD
T736VDPMLtPEERHAPP_amyloidPhosphoSitePlus
Y750MQNHGyENPTYAPP_amyloidPhosphoSitePlus
Y750MQNHGyENPTYHPRD; phosphoELM
Y755YENPTyKYLEQAPP_amyloidPhosphoSitePlus
Y757NPTYKyLEQMQAPP_amyloidPhosphoSitePlus
T736VDPMLtPEERHJNK1(MAPK8RegPhos
Y755YENPTyKYLEQHPRD; phosphoELM
T723KRQYGtISHGIPKCaRegPhos

Dephosphorylation site
APLP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263574E640DCOSMICOvarian Cancer21720365
ENSP00000263574M61TCOSMICOvarian Cancer21720365
ENSP00000435914G295SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000345444M61TTCGAOvarian Cancer21720365, 18772890
ENSP00000263574E263*COSMICHead and Neck Cancer21798893
ENSP00000263574S213LCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263574Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineUp4.214729644
ENSP00000263574Pancreatic CancerNormal vs. CancertissueUp5.519199705

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y750APP_amyloidNKMQNHGyENPTYKYcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANAPLP2_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANAPLP2_HUMANkinase -> substrateHPRD
MK08_HUMANAPLP2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
APLP2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0046914transition metal ion bindingIEAmolecular_function
GO:0001967suckling behaviorIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0030901midbrain developmentIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0043393regulation of protein bindingIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0007626locomotory behaviorIEAbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0008201heparin bindingIEAmolecular_function
GO:0007617mating behaviorIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0006878cellular copper ion homeostasisIEAbiological_process
GO:0007176regulation of epidermal growth factor-activated reIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003677DNA bindingNASmolecular_function


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