Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BUB1_HUMAN
Description:BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:1148]
Location:chr2 q13
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T609AQLAStPFHKLPhosphoSitePlus
T479MFQAPtLPDISPhosphoSitePlus
S969AKCETsGFQCVPkinase; Inhibitor_I68PhosphoSitePlus
Y761KPVSSyPNTFEPhosphoSitePlus
S655RDGKFsPIQEKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S445TTPNTsLGMVQHPRD; phosphoELM
S667PKQALsSHMYSPhosphoSitePlus
S511KNVRSsGAWGVPhosphoSitePlus; HPRD
S672SSHMYsASLLRPhosphoSitePlus
S331GPSVGsQQELRPhosphoSitePlus
Y219ISKSEySVHSSPhosphoSitePlus
S314EDLPAsQERSEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S411GCVNKsTHEFKPhosphoSitePlus
S969AKCETsGFQCVHPRD; phosphoELM
S593KTLAPsPKSPGPhosphoSitePlus; HPRD; phosphoELM
T609AQLAStPFHKLCDK1HPRD
T589IRCNKtLAPSPPhosphoSitePlus; HPRD; phosphoELM
T378LVSPAtSQSIAPhosphoSitePlus
T306HQVVEtSHEDLHPRD
S563VSRLPsKPKEEPhosphoSitePlus; HPRD
S679SLLRLsQPAAGPhosphoSitePlus
T461VQPSPtVHTKEPhosphoSitePlus; HPRD; SysPTM
S640QATLDsCEENMPhosphoSitePlus
S668KQALSsHMYSAPhosphoSitePlus
S755LLSGLsKPVSSPhosphoSitePlus; HPRD
S220SKSEYsVHSSLPhosphoSitePlus
S375SAALVsPATSQPhosphoSitePlus; HPRD
S596APSPKsPGDFTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S159AQARTsEPLHNHPRD
S608AAQLAsTPFHKHPRD; phosphoELM
S176MITSKsNPGNNPhosphoSitePlus
Y538GNKENyGLPQPPhosphoSitePlus
S661PIQEKsPKQALPhosphoSitePlus; HPRD; phosphoELM
S602PGDFTsAAQLAPhosphoSitePlus; HPRD; phosphoELM
S436KVANTsSFHTTHPRD; phosphoELM
S307QVVETsHEDLPPhosphoSitePlus; HPRD; phosphoELM
T440TSSFHtTPNTSHPRD
T609AQLAStPFHKLCDC2RegPhos
T452GMVQAtPSKVQPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
BUB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302530S492YOMIM, HPIColorectal Cancer9521327
ENSP00000302530H265NHPIPancreatic Cancer19487456 12655561
ENSP00000302530P648RHPIColorectal Cancer10366450
ENSP00000302530E36DHPIColorectal Cancer10366450
ENSP00000302530Y259CHPIPancreatic Cancer19487456 12655561
ENSP00000302530G25VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
BUB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BUB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BUB1_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANCENPS_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANPPIE_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANNOC2L_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANAIRE_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANNUP53_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANTOX_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANSMCA4_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANSTIP1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANCDC20_HUMANkinase -> substrateRegPhos
BUB1_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANPHAX_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANBUB1_HUMANkinase -> substrateRegPhos
BUB1_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANLAS1L_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANBUB1_HUMANkinase -> substrateHPRD; RegPhos
BUB1_HUMANLRIG1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANXRCC1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANZN765_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANZN823_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000780condensed nuclear chromosome, centromeric regionIEAcellular_component
GO:0051983regulation of chromosome segregationIMPbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007063regulation of sister chromatid cohesionIDAbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0071173spindle assembly checkpointIDAbiological_process
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0007059chromosome segregationIEAbiological_process
GO:0000777condensed chromosome kinetochoreIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0000776kinetochoreIEAcellular_component
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0007093mitotic cell cycle checkpointTASbiological_process
GO:0008283cell proliferationIEAbiological_process