| UniProt/SwissProt ID: | EF1D_HUMAN |
| Description: | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) [Source:HGNC Symbol;Acc:3211] |
| Location: | chr8 q24.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S133 | QTQHVsPMRQV | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus; SysPTM |
| S484 | NVLEKsSPGHR | HPRD | |
| S64 | KSLAGsSGPGA | DUF4349; Reo_sigmaC | PhosphoSitePlus |
| T125 | PGHRAtAPQTQ | HPRD | |
| S60 | ENIQKsLAGSS | HPRD; phosphoELM; RegPhos; SysPTM | |
| S91 | KKRKRsPKSGL | HPRD | |
| S86 | VVRIAsLEVEN | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus |
| Y26 | AERRFyEQMNG | DUF4349 | PhosphoSitePlus |
| T513 | AKKPAtPAEDD | HPRD | |
| S431 | SLAGSsGPGAS | HPRD | |
| T495 | ATAPQtQHVSP | HPRD | |
| T129 | ATAPQtQHVSP | HPRD; phosphoELM; RegPhos; SysPTM | |
| S133 | QTQHVsPMRQV | CDK1 | HPRD; SysPTM |
| S499 | QTQHVsPMRQV | HPRD | |
| T147 | AKKPAtPAEDD | HPRD; phosphoELM; RegPhos; SysPTM | |
| S119 | VLEKSsPGHRA | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus; SysPTM |
| S65 | SLAGSsGPGAS | HPRD | |
| S119 | VLEKSsPGHRA | HPRD; phosphoELM; RegPhos; SysPTM | |
| S44 | QENGAsVILRD | DUF4349 | PhosphoSitePlus |
| Y18 | FDKFKyDDAER | PhosphoSitePlus | |
| S485 | VLEKSsPGHRA | HPRD | |
| S133 | QTQHVsPMRQV | HPRD; phosphoELM; RegPhos; SysPTM | |
| S452 | VVRIAsLEVEN | HPRD | |
| T147 | AKKPAtPAEDD | Striatin | PhosphoSitePlus; SysPTM |
| S74 | ASSGTsGDHGE | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus |
| T125 | PGHRAtAPQTQ | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus |
| Y182 | ERLRQyAEKKA | Striatin; EF-1_beta_acid; | PhosphoSitePlus |
| T491 | PGHRAtAPQTQ | HPRD | |
| S65 | SLAGSsGPGAS | DUF4349; Reo_sigmaC | PhosphoSitePlus |
| S118 | NVLEKsSPGHR | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus; SysPTM |
| S94 | KRSPKsGLGPA | HPRD | |
| S86 | VVRIAsLEVEN | HPRD | |
| S426 | ENIQKsLAGSS | HPRD | |
| S60 | ENIQKsLAGSS | DUF4349; Reo_sigmaC | PhosphoSitePlus; SysPTM |
| S37 | PVAGAsRQENG | DUF4349 | PhosphoSitePlus |
| S162 | IDLFGsDNEEE | HPRD; phosphoELM; RegPhos; SysPTM | |
| S162 | IDLFGsDNEEE | Striatin; EF-1_beta_acid | PhosphoSitePlus; SysPTM |
| S528 | IDLFGsDNEEE | HPRD | |
| T129 | ATAPQtQHVSP | DUF4349; Reo_sigmaC; Stri | PhosphoSitePlus; SysPTM |
| S499 | QTQHVsPMRQV | CDK1 | HPRD |
| S118 | NVLEKsSPGHR | HPRD; SysPTM | |
| Y238 | LVPVGyGIRKL | EF1_GNE | PhosphoSitePlus |
| S197 | LVAKSsILLDV | Striatin; MinC_N; EF1_GNE | PhosphoSitePlus |
| S133 | QTQHVsPMRQV | CDC2 | RegPhos; SysPTM |
| Dephosphorylation site |
| EF1D_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000391944 | I377F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000410059 | I377F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000391944 | G68V | COSMIC | Renal Cancer | ENSP00000410059 | V159M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000391944 | V159M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000410059 | G68V | COSMIC | Renal Cancer |
| Differential expressed protein |
| EF1D_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EF1D_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | EF1D_HUMAN | kinase -> substrate | RegPhos |
| PDPK1_HUMAN | EF1D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AAPK2_HUMAN | EF1D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | EF1D_HUMAN | kinase -> substrate | HPRD; RegPhos |
| STK16_HUMAN | EF1D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| OXSR1_HUMAN | EF1D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05168 | Herpes simplex infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | IMP | biological_process |
| GO:0008135 | translation factor activity, nucleic acid binding | TAS | molecular_function |
| GO:0004871 | signal transducer activity | IMP | molecular_function |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006412 | translation | TAS | biological_process |
| GO:0006414 | translational elongation | TAS | biological_process |
| GO:0005853 | eukaryotic translation elongation factor 1 complex | IEA | cellular_component |
| GO:0003746 | translation elongation factor activity | IEA | molecular_function |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |