| UniProt/SwissProt ID: | NSF1C_HUMAN |
| Description: | NSFL1 (p97) cofactor (p47) [Source:HGNC Symbol;Acc:15912] |
| Location: | chr20 p13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T354 | ADESQtLKEAN | Spt20; UBX | PhosphoSitePlus |
| Y155 | FAGGGyRLGAA | PhosphoSitePlus | |
| S241 | VLSTSsPAQQA | HPRD | |
| Y167 | EEESAyVAGEK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S192 | WKSGFsLDNGE | Spt20; SEP | PhosphoSitePlus |
| S176 | EKRQHsSQDVH | HPRD; RegPhos | |
| S114 | PPRKKsPNELV | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S177 | KRQHSsQDVHV | HPRD | |
| S176 | EKRQHsSQDVH | Spt20 | PhosphoSitePlus |
| S272 | VLSTSsPAQQA | Spt20 | PhosphoSitePlus |
| T73 | SDNRVtSFRDL | PhosphoSitePlus | |
| S177 | KRQHSsQDVHV | Spt20 | PhosphoSitePlus |
| S140 | ERVTKsPGETS | CDC2(CDK1 | RegPhos; SysPTM |
| S271 | QVLSTsSPAQQ | HPRD; phosphoELM | |
| Y95 | EGQRFyAGGSE | PhosphoSitePlus | |
| S140 | ERVTKsPGETS | CDK1 | HPRD; phosphoELM; SysPTM |
| S29 | RFFLEsAGWDL | CDC2 | RegPhos |
| S165 | APEEEsAYVAG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S240 | QVLSTsSPAQQ | HPRD | |
| S272 | VLSTSsPAQQA | HPRD; phosphoELM; RegPhos | |
| S74 | DNRVTsFRDLI | HPRD; phosphoELM; RegPhos | |
| S140 | ERVTKsPGETS | PhosphoSitePlus; phosphoELM; SysPTM | |
| S140 | ERVTKsPGETS | CDC2 | RegPhos; SysPTM |
| Dephosphorylation site |
| NSF1C_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000371074 | R88K | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000338643 | R168K | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000216879 | R199K | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000418529 | R201K | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000371074 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 2.9 | 15759316 |
| Hyperphosphorylation site |
| NSF1C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | NSF1C_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | NSF1C_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04141 | Protein processing in endoplasmic reticulum |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005694 | chromosome | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0005795 | Golgi stack | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |