Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGCC_HUMAN
Description:regulator of cell cycle [Source:HGNC Symbol;Acc:20369]
Location:chr13 q14.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S97DEKLNsPTDSTPhosphoSitePlus; HPRD
S89YRNSFsFSDEKPhosphoSitePlus
T111LSATVtPQKAKCDK1HPRD
S65MKRRSsASVSDPhosphoSitePlus
S29AAEDLsDALCEHPRD; phosphoELM
S69SSASVsDSSGFPhosphoSitePlus
S75DSSGFsDSESAPhosphoSitePlus
S91NSFSFsDEKLNPhosphoSitePlus; HPRD
S77SGFSDsESADSPhosphoSitePlus
S71ASVSDsSGFSDPhosphoSitePlus
S44LADFAsPFHERPhosphoSitePlus; HPRD; phosphoELM
T102SPTDStPALLSPhosphoSitePlus
Y53ERHFHyEEHLEPhosphoSitePlus
T111LSATVtPQKAKPhosphoSitePlus
T99KLNSPtDSTPAPhosphoSitePlus; HPRD
S9PAAQGsPAAAAHPRD; phosphoELM

Dephosphorylation site
RGCC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368664D27NCOSMICSkin Cancer21984974

Differential expressed protein
RGCC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RGCC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANRGCC_HUMANkinase -> substrateRegPhos
TNI3K_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANRGCC_HUMANkinase -> substrateHPRD; RegPhos
BMX_HUMANRGCC_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RGCC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016525negative regulation of angiogenesisIDAbiological_process
GO:0050710negative regulation of cytokine secretionIMPbiological_process
GO:0060630regulation of M/G1 transition of mitotic cell cyclIDAbiological_process
GO:0045750positive regulation of S phase of mitotic cell cycIDAbiological_process
GO:0008285negative regulation of cell proliferationIMPbiological_process
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0090272negative regulation of fibroblast growth factor prIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051496positive regulation of stress fiber assemblyIDAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0071456cellular response to hypoxiaIMPbiological_process
GO:0072537fibroblast activationISSbiological_process
GO:2000048negative regulation of cell-cell adhesion mediatedIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0071158positive regulation of cell cycle arrestIDAbiological_process
GO:0032967positive regulation of collagen biosynthetic proceIDAbiological_process
GO:0030295protein kinase activator activityIDAmolecular_function
GO:0001100negative regulation of exit from mitosisIDAbiological_process
GO:0006956complement activationIMPbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIMPbiological_process
GO:2000573positive regulation of DNA biosynthetic processIEAbiological_process
GO:0071850mitotic cell cycle arrestIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0050715positive regulation of cytokine secretionIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010718positive regulation of epithelial to mesenchymal tIMPbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:2000353positive regulation of endothelial cell apoptotic IDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0001937negative regulation of endothelial cell proliferatIDAbiological_process
GO:0045840positive regulation of mitosisIMPbiological_process
GO:0005813centrosomeIDAcellular_component
GO:2000573positive regulation of DNA biosynthetic processISSbiological_process
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:1901313positive regulation of gene expression involved inIDAbiological_process
GO:0072537fibroblast activationIEAbiological_process
GO:0019901protein kinase bindingISSmolecular_function
GO:0003331positive regulation of extracellular matrix constiIDAbiological_process