| UniProt/SwissProt ID: | GRK5_HUMAN |
| Description: | G protein-coupled receptor kinase 5 [Source:HGNC Symbol;Acc:4544] |
| Location: | chr10 q26.11 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S484 | DIEQFsTVKGV | GRK-5 | phosphoELM |
| S484 | DIEQFsTVKGV | GRK5 | HPRD |
| T485 | IEQFStVKGVN | autocatalysis | RegPhos |
| T485 | IEQFStVKGVN | GRK5 | HPRD |
| Y408 | ETEEVySHKFS | Pkinase_AGC | PhosphoSitePlus |
| S484 | DIEQFsTVKGV | autocatalysis | RegPhos |
| S27 | KRKGKsKKWKE | PhosphoSitePlus | |
| S484 | DIEQFsTVKGV | PhosphoSitePlus; phosphoELM | |
| S484 | DIEQFsTVKGV | GPRK5 | RegPhos |
| S40 | KFPHIsQCEDL | PhosphoSitePlus | |
| T485 | IEQFStVKGVN | GPRK5 | RegPhos |
| S586 | HVSSNsTGSS_ | PhosphoSitePlus | |
| S484 | DIEQFsTVKGV | GPRK5(GRK5 | RegPhos |
| T485 | IEQFStVKGVN | GRK-5 | phosphoELM |
| T485 | IEQFStVKGVN | PhosphoSitePlus; phosphoELM | |
| T485 | IEQFStVKGVN | GPRK5(GRK5 | RegPhos |
| Dephosphorylation site |
| GRK5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376609 | D163E | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| GRK5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRK5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRK5_HUMAN | ASAP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | BMX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | RGCC_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK18_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K8_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ZYX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ADRB2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| GRK5_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PRKY_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK9_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | SYUG_HUMAN | kinase -> substrate | HPRD; RegPhos |
| GRK5_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | SYUA_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| GRK5_HUMAN | TNFA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | SYUB_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CDK6_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST1_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | KCC2A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | PQBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | PINX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | IF4H_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACK1_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | GRK5_HUMAN | kinase -> substrate | RegPhos |
| PKN1_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RPKL1_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | ENOA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K14_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK14_HUMAN | GRK5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | BKRB2_HUMAN | kinase -> substrate | RegPhos |
| GRK5_HUMAN | SRXN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa05032 | Morphine addiction |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005543 | phospholipid binding | TAS | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0007217 | tachykinin receptor signaling pathway | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | TAS | biological_process |
| GO:0005080 | protein kinase C binding | TAS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0004703 | G-protein coupled receptor kinase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0008277 | regulation of G-protein coupled receptor protein s | TAS | biological_process |