Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITPR1_HUMAN
Description:inositol 1,4,5-trisphosphate receptor, type 1 [Source:HGNC Symbol;Acc:6180]
Location:chr3 p26.1
Node attribute:PPI(target); Enzyme(target); Enzyme(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T2434VYREEtLLNVIIon_transPhosphoSitePlus
T1766RRESLtSFGNGPhosphoSitePlus
T2655TMKLVtNLSGQHPRD
S1598AARRDsVLAASPKACaRegPhos
Y2664KDSTEyTGPESRegPhos
S2693AMSLVsSDSEGPhosphoSitePlus
S1729GSGSSsMSRGEHPRD
S421LKIGTsPVKEDCDC2RegPhos
S689LFWRDsNKEIRHPRD
S1598AARRDsVLAASPhosphoSitePlus; phosphoELM; RegPhos
S1767RESLTsFGNGPPhosphoSitePlus; phosphoELM
T800PQEQVtPVKYACDC2RegPhos
Y1144SELWVyKGQGPPhosphoSitePlus
S1577FLKSHsIVQKTPhosphoSitePlus
S1731GSSSMsRGEMSHPRD
Y353QEKMVySLVSVMIRPhosphoSitePlus
Y482LEDLVyFVTGGRegPhos
T1238EKAEDtKMQEIRYDR_ITPRPhosphoSitePlus
S1764SGRREsLTSFGPhosphoSitePlus; phosphoELM
T1703RRESLtSFGNGHPRD
T1937RKAFTtFRREAPhosphoSitePlus
T276SATSAtSSKALMIRPhosphoSitePlus
S1764SGRREsLTSFGPKA_groupRegPhos
S1728GGSGSsSMSRGHPRD
S2696LVSSDsEGEQNPhosphoSitePlus
S1711GNGPLsAGGPGHPRD
S2694MSLVSsDSEGEPhosphoSitePlus
T2669LKDQMtEQRKQHPRD
T800PQEQVtPVKYAPhosphoSitePlus
Y353QEKMVySLVSVFYNRegPhos
S704LFWRDsNKEIRPhosphoSitePlus
Y353QEKMVySLVSVFynphosphoELM; RegPhos
S277ATSATsSKALWMIRPhosphoSitePlus
S1764SGRREsLTSFGPKG1RegPhos
S1574AARRDsVLAASHPRD
Y1183TSSYNyRVVKEPhosphoSitePlus
S1774GNGPLsAGGPGPhosphoSitePlus
Y298RGGAGyWNSLFMIRPhosphoSitePlus
S1764SGRREsLTSFGPKACaRegPhos
T955GFLPMtPMAAAPhosphoSitePlus
S1701SGRREsLTSFGHPRD
S1704RESLTsFGNGPHPRD
S421AIVPVsPAEVRCDK1HPRD
Y2275AQPVLyWCARNPhosphoSitePlus
Y2212AQPVLyWCARNHPRD
T1687IKVLQtLREMMPhosphoSitePlus
S421LKIGTsPVKEDMIRPhosphoSitePlus
S2690RMRAMsLVSSDPhosphoSitePlus
T420MLKIGtSPVKEMIRPhosphoSitePlus
Y2649HNMWHyLCFIVPhosphoSitePlus

Dephosphorylation site
ITPR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000397885E599DBIOMARTBreast Cancer21930507, 21930502
ENSP00000397885R2110WCOSMICBreast Cancer20668451
ENSP00000397885K902ECOSMICLung Cancer20668451
ENSP00000349597E614DBIOMARTBreast Cancer21930507, 21930502
ENSP00000349597E2442ABIOMARTBreast Cancer21930507, 21930502
ENSP00000397885V483DCOSMICLung Cancer20668451
ENSP00000397885E2427ABIOMARTBreast Cancer21930507, 21930502
ENSP00000397885N129TCOSMICLung Cancer20668451
ENSP00000397885V1593ICOSMICLung Cancer20668451
ENSP00000397885K2409NCOSMICOvarian Cancer21720365
ENSP00000397885R489KCOSMICMelanoma
ENSP00000397885R491WCOSMICLung Cancer20668451
ENSP00000397885R170QCOSMICPancreatic Cancer
ENSP00000397885G2303SCOSMICOvarian Cancer21720365
ENSP00000349597C1672SBIOMARTBreast Cancer21930507, 21930502
ENSP00000397885C1657SBIOMARTBreast Cancer21930507, 21930502
ENSP00000397885R1345WCOSMICHepatocellular Carcinoma
ENSP00000397885S1008ICOSMICBreast Cancer17932254

Differential expressed protein
ITPR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITPR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANITPR1_HUMANkinase -> substrateRegPhos
LYN_HUMANITPR1_HUMANkinase -> substrateNetPath
CDK1_HUMANITPR1_HUMANkinase -> substrateRegPhos
KGP1_HUMANITPR1_HUMANkinase -> substrateHPRD
KPCA_HUMANITPR1_HUMANkinase -> substrateHPRD
FYN_HUMANITPR1_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
ITPR1_HUMANPI5PA_HUMANenzyme catalysisKEGG
ITPR1_HUMANIP3KA_HUMANenzyme catalysisKEGG
PLCD3_HUMANITPR1_HUMANenzyme catalysisKEGG
PLCD3_HUMANITPR1_HUMANotherKEGG
PLCE1_HUMANITPR1_HUMANotherKEGG
PLCZ1_HUMANITPR1_HUMANotherKEGG
PLCB1_HUMANITPR1_HUMANotherKEGG
PLCG1_HUMANITPR1_HUMANotherKEGG
ITPR1_HUMANCALL6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04912GnRH signaling pathway
hsa04540Gap junction
hsa04270Vascular smooth muscle contraction
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa05016Huntington's disease
hsa04720Long-term potentiation
hsa04970Salivary secretion
hsa04725Cholinergic synapse
hsa05010Alzheimer's disease
hsa04114Oocyte meiosis
hsa04070Phosphatidylinositol signaling system
hsa04971Gastric acid secretion
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04972Pancreatic secretion
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044281small molecule metabolic processTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0031088platelet dense granule membraneIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006816calcium ion transportNASbiological_process
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-relISSmolecular_function
GO:0005783endoplasmic reticulumNAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0070059intrinsic apoptotic signaling pathway in response ISSbiological_process
GO:0031094platelet dense tubular networkIDAcellular_component
GO:0035091phosphatidylinositol bindingISSmolecular_function
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0048016inositol phosphate-mediated signalingISSbiological_process
GO:0031095platelet dense tubular network membraneTAScellular_component
GO:0015085calcium ion transmembrane transporter activityTASmolecular_function
GO:0005216ion channel activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0055085transmembrane transportIEAbiological_process
GO:0006811ion transportIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051209release of sequestered calcium ion into cytosolISSbiological_process
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005262calcium channel activityIEAmolecular_function
GO:0005218intracellular ligand-gated calcium channel activitISSmolecular_function


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