| UniProt/SwissProt ID: | MPIP1_HUMAN |
| Description: | cell division cycle 25A [Source:HGNC Symbol;Acc:1725] |
| Location: | chr3 p21.31 |
| Node attribute: | phosphotase; substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S124 | LKRSHsDSLDH | CHK2 | phosphoELM; RegPhos |
| S124 | LKRSHsDSLDH | CHK1 | phosphoELM; RegPhos |
| S293 | TKRRKsMSGAS | CHK1 | phosphoELM; RegPhos |
| S295 | RRKSMsGASPK | M-inducer_phosp | PhosphoSitePlus |
| S82 | SESTDsGFCLD | PhosphoSitePlus; phosphoELM; RegPhos | |
| S76 | LQRMGsSESTD | CHK1 | phosphoELM; RegPhos |
| S293 | TKRRKsMSGAS | M-inducer_phosp | PhosphoSitePlus |
| S116 | KLLGCsPALKR | PIM1 | HPRD; RegPhos |
| S116 | KLLGCsPALKR | M-inducer_phosp | PhosphoSitePlus |
| S124 | LKRSHsDSLDH | HPRD | |
| S178 | TQRQNsAPARM | CHEK1 | HPRD |
| S178 | TQRQNsAPARM | CHEK2 | HPRD |
| S77 | QRMGSsESTDS | PhosphoSitePlus | |
| S519 | KREMYsRLKKL | PhosphoSitePlus | |
| S279 | KRPERsQEESP | CHEK2 | HPRD |
| T507 | RTKSRtWAGEK | PhosphoSitePlus | |
| S239 | PSCMAsLWTAP | CHK2 | RegPhos |
| S239 | PSCMAsLWTAP | CHK1 | RegPhos |
| S76 | LQRMGsSESTD | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S116 | KLLGCsPALKR | PIM-1 | phosphoELM |
| S116 | KLLGCsPALKR | CDC2(CDK1 | RegPhos |
| S513 | WAGEKsKREMY | PhosphoSitePlus | |
| S116 | KLLGCsPALKR | CDK1 | HPRD; phosphoELM |
| S293 | TKRRKsMSGAS | CHEK1 | HPRD |
| S293 | TKRRKsMSGAS | CHEK2 | HPRD |
| S18 | LLFACsPPPAS | PhosphoSitePlus | |
| S124 | LKRSHsDSLDH | M-inducer_phosp | PhosphoSitePlus |
| S116 | KLLGCsPALKR | CDC2 | RegPhos |
| S253 | TKRRKsMSGAS | CHEK1 | HPRD |
| S253 | TKRRKsMSGAS | CHEK2 | HPRD |
| S279 | KRPERsQEESP | CHEK1 | HPRD |
| S178 | TQRQNsAPARM | CHK2 | phosphoELM; RegPhos |
| S178 | TQRQNsAPARM | CHK1 | phosphoELM; RegPhos |
| S124 | LKRSHsDSLDH | CHEK1 | HPRD |
| S79 | MGSSEsTDSGF | PhosphoSitePlus; phosphoELM; RegPhos | |
| S88 | GFCLDsPGPLD | M-inducer_phosp | PhosphoSitePlus |
| T507 | RTKSRtWAGEK | CHK1 | phosphoELM; RegPhos |
| S18 | LLFACsPPPAS | CDK1 | HPRD; phosphoELM |
| S279 | KRPERsQEESP | M-inducer_phosp | PhosphoSitePlus |
| S321 | LSLASsPKGTI | M-inducer_phosp | PhosphoSitePlus |
| S88 | GFCLDsPGPLD | phosphoELM; RegPhos | |
| S126 | RSHSDsLDHDI | M-inducer_phosp | PhosphoSitePlus |
| S178 | TQRQNsAPARM | M-inducer_phosp | PhosphoSitePlus |
| T80 | GSSEStDSGFC | PhosphoSitePlus | |
| S18 | LLFACsPPPAS | CDC2(CDK1 | RegPhos |
| S279 | KRPERsQEESP | CHK2 | phosphoELM; RegPhos |
| S279 | KRPERsQEESP | CHK1 | phosphoELM; RegPhos |
| S293 | TKRRKsMSGAS | CHK2 | phosphoELM; RegPhos |
| S18 | LLFACsPPPAS | CDC2 | RegPhos |
| S239 | KRPERsQEESP | CHEK2 | HPRD |
| S239 | KRPERsQEESP | CHEK1 | HPRD |
| Dephosphorylation site |
| MPIP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303706 | E147K | COSMIC | Lung Cancer | 20668451 | ENSP00000303706 | R506Q | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000303706 | F218I | COSMIC | Renal Cancer | 20054297 | ENSP00000303706 | G37W | Ding2008, COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000303706 | Uterine Cancer | Normal vs. Cancer | cell line | Up | 2.2 | 15838902 |
| Hyperphosphorylation site |
| MPIP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CHK2_HUMAN | MPIP1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| PIM1_HUMAN | MPIP1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| CHK1_HUMAN | MPIP1_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | MPIP1_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | MPIP1_HUMAN | kinase -> substrate | RegPhos |
| TGFR2_HUMAN | MPIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK03_HUMAN | MPIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MPIP1_HUMAN | CDK2_HUMAN | phosphatase -> substrate | KEGG |
| MPIP1_HUMAN | CDK1_HUMAN | phosphatase -> substrate | KEGG |
| MPIP1_HUMAN | RAF1_HUMAN | phosphatase -> substrate | HPRD |
| MPIP1_HUMAN | CDK4_HUMAN | phosphatase -> substrate | KEGG |
| E2F1_HUMAN | MPIP1_HUMAN | TF -> target gene | TRANSFAC |
| MYC_HUMAN | MPIP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0009314 | response to radiation | IDA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0034644 | cellular response to UV | IDA | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0000087 | M phase of mitotic cell cycle | IEA | biological_process |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |