Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RFA2_HUMAN
Description:replication protein A2, 32kDa [Source:HGNC Symbol;Acc:10290]
Location:chr1 p35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S8NSGFEsYGSSSDNAPKRegPhos
S4MWNSGfESYRegPhos
S174LSKANsQPSAGRPA_CPhosphoSitePlus
S23GGYTQsPGGFGPhosphoSitePlus
S12ESYGSsSYGGAPhosphoSitePlus; phosphoELM; RegPhos
Y14YGSSSyGGAGGPhosphoSitePlus
S13SYGSSsYGGAGPhosphoSitePlus; phosphoELM; RegPhos
S8NSGFEsYGSSSPRKDCHPRD
S33GSPAPsQAEKKDNAPKRegPhos
S13SYGSSsYGGAGDNAPKRegPhos
T21GAGGYtQSPGGPRKDCHPRD
S4FESYphosphoELM
T21GAGGYtQSPGGDNA-PKphosphoELM
Y9SGFESyGSSSYPhosphoSitePlus
S33GSPAPsQAEKKDNA-PKphosphoELM
T21GAGGYtQSPGGPhosphoSitePlus
S4MWNSGfESYDNAPKRegPhos
S238QLKHMsVSSIKRPA_C; SWIRMPhosphoSitePlus
S29PGGFGsPAPSQPhosphoSitePlus
S23GGYTQsPGGFGCDC2(CDK1RegPhos
S13SYGSSsYGGAGPRKDCHPRD
S52VPCTIsQLLSAPhosphoSitePlus
S29PGGFGsPAPSQCDC2(CDK1RegPhos
S29PGGFGsPAPSQCDC2RegPhos
S12ESYGSsSYGGADNAPKRegPhos
S33GSPAPsQAEKKPRKDCHPRD
S11FESYGsSSYGGDNAPKRegPhos
T88AEKAPtNIVYKtRNA_antiPhosphoSitePlus
S12ESYGSsSYGGAPRKDCHPRD
S8NSGFEsYGSSSPhosphoSitePlus; phosphoELM; RegPhos
S23GGYTQsPGGFGCDK1HPRD; phosphoELM
S11FESYGsSSYGGPRKDCHPRD
S29PGGFGsPAPSQCDK1HPRD; phosphoELM
S4FESYPRKDCHPRD
T21GAGGYtQSPGGDNAPKRegPhos
S11FESYGsSSYGGPhosphoSitePlus; phosphoELM; RegPhos
S4__MWNsGFESYPhosphoSitePlus
S33GSPAPsQAEKKPhosphoSitePlus
T21GAGGYtQSPGGATMphosphoELM; RegPhos
S39QAEKKsRARAQHPRD; phosphoELM
S23GGYTQsPGGFGCDC2RegPhos
S72GNVEIsQVTIVPhosphoSitePlus

Dephosphorylation site
RFA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363021M102ICOSMICMelanoma21499247
ENSP00000363015M190ICOSMICMelanoma21499247

Differential expressed protein
RFA2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RFA2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANRFA2_HUMANkinase -> substrateRegPhos
MK09_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
PRKDC_HUMANRFA2_HUMANkinase -> substrateHPRD
CDK4_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANRFA2_HUMANkinase -> substrateRegPhos
ATM_HUMANRFA2_HUMANkinase -> substrateRegPhos
TBK1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CSK_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A3_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03460Fanconi anemia pathway
hsa03430Mismatch repair
hsa03420Nucleotide excision repair
hsa03440Homologous recombination
hsa03030DNA replication

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016605PML bodyIEAcellular_component
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0010569regulation of double-strand break repair via homolIMPbiological_process
GO:0006302double-strand break repairTASbiological_process
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0000730DNA recombinase assemblyTASbiological_process
GO:0006297nucleotide-excision repair, DNA gap fillingTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0032201telomere maintenance via semi-conservative replicaTASbiological_process
GO:0000723telomere maintenanceTASbiological_process
GO:0005662DNA replication factor A complexIEAcellular_component
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0000722telomere maintenance via recombinationTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0006261DNA-dependent DNA replicationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006289nucleotide-excision repairTASbiological_process