| UniProt/SwissProt ID: | APC4_HUMAN |
| Description: | anaphase promoting complex subunit 4 [Source:HGNC Symbol;Acc:19990] |
| Location: | chr4 p15.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S488 | DDDLVsPPNTE | PhosphoSitePlus | |
| Y516 | PLLFPyYPRKS | PhosphoSitePlus | |
| S779 | EVLSEsEAENQ | PLK1 | phosphoELM |
| S736 | SCVLSsNLRHV | HPRD | |
| Y469 | NRKGKyFNVER | PhosphoSitePlus; phosphoELM | |
| S757 | WELDEsSDEEE | PhosphoSitePlus | |
| T87 | FALADtKKIVL | PhosphoSitePlus | |
| Y625 | FGSFTyATTEK | PhosphoSitePlus | |
| T628 | FTYATtEKVRR | PhosphoSitePlus | |
| S758 | ELDESsDEEEE | PhosphoSitePlus | |
| S777 | KEEVLsESEAE | PhosphoSitePlus; HPRD; phosphoELM | |
| T627 | SFTYAtTEKVR | PhosphoSitePlus | |
| T429 | AMLRMtEDHVL | PhosphoSitePlus | |
| S779 | EVLSEsEAENQ | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| APC4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318775 | I155V | HPI | Colorectal Cancer | 16959974 | ENSP00000318775 | P515S | COSMIC | Melanoma | 21499247 | ENSP00000318775 | I155V | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000318775 | V220L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318775 | L671F | COSMIC | Pancreatic Cancer | ENSP00000318775 | V220L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| APC4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| APC4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | APC4_HUMAN | kinase -> substrate | RegPhos |
| PLK1_HUMAN | APC4_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | APC4_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04114 | Oocyte meiosis |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa05166 | HTLV-I infection |
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005680 | anaphase-promoting complex | IEA | cellular_component |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0007067 | mitosis | TAS | biological_process |
| GO:0070979 | protein K11-linked ubiquitination | IDA | biological_process |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0004842 | ubiquitin-protein ligase activity | TAS | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0000090 | mitotic anaphase | TAS | biological_process |
| GO:0030071 | regulation of mitotic metaphase/anaphase transitio | IEA | biological_process |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0019903 | protein phosphatase binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | IEA | biological_process |