Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:P3C2A_HUMAN
Description:phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Source:HGNC Symbol;Acc:8971]
Location:chr11 p15.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y737YKNFFyLIKWDPI3K_C2PhosphoSitePlus
S126PILSPsFSAQLPhosphoSitePlus
S259SNLQVsPKSEDCDC2(CDK1RegPhos; SysPTM
T120PVLPVtPILSPPhosphoSitePlus
Y73YNKQDyDLMVFPhosphoSitePlus; HPRD
S327KVNGKsLSVATPhosphoSitePlus
Y1632LVYSGySKETLC2PhosphoSitePlus
S1551SADAGsFSPTPHPRD
S672TDCAQsSKSVKPhosphoSitePlus
S6MAQISsNSGFKPhosphoSitePlus
S124VTPILsPSFSAPhosphoSitePlus
S771GILNQsSGSSPPI3K_C2PhosphoSitePlus
S665ANSGRsPTDCAPhosphoSitePlus
S1553DAGSFsPTPGQPhosphoSitePlus; HPRD; SysPTM
S1633VYSGYsKETLRC2PhosphoSitePlus
S673DCAQSsKSVKEPhosphoSitePlus
S5_MAQIsSNSGFPhosphoSitePlus
Y900LWEKRyYCFKHPI3KaPhosphoSitePlus
Y68KKAQVyNKQDYPhosphoSitePlus
Y1595ADPNPyVKTYLC2PhosphoSitePlus
Y901WEKRYyCFKHPPI3KaPhosphoSitePlus
S259SNLQVsPKSEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S108LLLDDsFETKKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S409PGYLLsPVTAQPI3K_rbdPhosphoSitePlus
S234KIASTsEFLKNPhosphoSitePlus
S772ILNQSsGSSPDPI3K_C2PhosphoSitePlus
S60FELSSsTRKKAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S338VTRSQsLNIRTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S778GSSPDsNKQRKPI3K_C2PhosphoSitePlus
S336ATVTRsQSLNIPhosphoSitePlus
S8QISSNsGFKECPhosphoSitePlus
T667SGRSPtDCAQSPhosphoSitePlus
S259SNLQVsPKSEDCDK1phosphoELM; SysPTM

Dephosphorylation site
P3C2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265970I1307MCOSMICOvarian Cancer21720365
ENSP00000265970N569ICOSMICGastric Cancer21097718
ENSP00000265970A916TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000265970A650VDing2008, COSMICLung Cancer18948947
ENSP00000265970E1080DCOSMICLung Cancer20668451
ENSP00000265970F1206LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000265970V600ICOSMICOvarian Cancer21720365
ENSP00000265970N359SCOSMICLung Cancer20668451
ENSP00000265970H400QCOSMICOvarian Cancer21720365
ENSP00000265970R1081*COSMICCentral Nervous System Neoplasms18772890
ENSP00000265970M1183VDing2008, COSMICLung Cancer18948947

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265970Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
P3C2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANP3C2A_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANP3C2A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
hsa00562Inositol phosphate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048008platelet-derived growth factor receptor signaling TASbiological_process
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0035004phosphatidylinositol 3-kinase activityTASmolecular_function
GO:0030136clathrin-coated vesicleIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0006897endocytosisIMPbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0048268clathrin coat assemblyTASbiological_process
GO:0005488bindingIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0031982vesicleIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activiTASmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0014829vascular smooth muscle contractionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:00163031-phosphatidylinositol-3-kinase activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0006887exocytosisTASbiological_process


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