Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAP4_HUMAN
Description:microtubule-associated protein 4 [Source:HGNC Symbol;Acc:6862]
Location:chr3 p21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T806SKSTQtVAKTTPhosphoSitePlus
S94HGVEGsDTTGSHPRD; RegPhos
T101TTGSPtEFLEEPhosphoSitePlus; HPRD
S941RSKVGsTENIKMARK1HPRD; RegPhos
T326RWPTEtDVSSAPhosphoSitePlus
T927RLATNtSAPDLTubulin-bindingPhosphoSitePlus
T496DVAPStVKEVGPhosphoSitePlus; HPRD
T526TPPPEtEVVLIPhosphoSitePlus; HPRD; RegPhos
T582PPLSEtEATPVHPRD; phosphoELM
S60EKTGNsESKKKPhosphoSitePlus; HPRD; phosphoELM
S510DMSPLsETEMAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S803RSGSKsTQTVAPhosphoSitePlus
S928LATNTsAPDLKTubulin-bindingPhosphoSitePlus
T892SRVKAtPMPSRPhosphoSitePlus
T901SRPSTtPFIDKPhosphoSitePlus
T484AQLPEtEIAPAPhosphoSitePlus; HPRD; RegPhos
T57DVDEKtGNSESHPRD; phosphoELM
T512SPLSEtEMALGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T627MISPEtVTGTGPhosphoSitePlus; SysPTM
S1036DISKVsSKCGSHPRD; phosphoELM
S787PEKRAsPSKPACDC2(CDK1RegPhos
S602TQKGIsEDSHLphosphoELM
T687GNDITtPPNKENBP1PhosphoSitePlus
T282DMESPtKLDVTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T45ETVGKtDYIPLPhosphoSitePlus
S787PEKRAsPSKPACDC2RegPhos
S624PTFMIsPETVTPhosphoSitePlus; HPRD
T256APSKEtEMALAPhosphoSitePlus; HPRD
T216EPPQPtAVPLEHPRD
S696KELPPsPEKKTHPRD; phosphoELM; RegPhos; SysPTM
Y113MAYQEyPNSQNPhosphoSitePlus
T942SKVGStENIKHTubulin-bindingPhosphoSitePlus
T565KDGVLtLANNVHPRD; phosphoELM
T96VEGSDtTGSPTHPRD; RegPhos
T686TGNDItTPPNKNBP1PhosphoSitePlus
T965TEAAAtTRKPEHPRD
S495KDVAPsTVKEVPhosphoSitePlus; HPRD
S1073QAKVGsLDNVGTubulin-bindingPhosphoSitePlus; SysPTM
S696KELPPsPEKKTNBP1PhosphoSitePlus; SysPTM
S1041SSKCGsKANIKHPRD; phosphoELM
S915SAKPSsTTPRLHPRD; RegPhos
S764ASARPsILPSKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T900PSRPStTPFIDPhosphoSitePlus
S928LATNTsAPDLKMARK1HPRD; RegPhos
S876KTTTLsGTAPAPhosphoSitePlus; HPRD
T712TQPAKtSTSKANBP1PhosphoSitePlus
T810QTVAKtTTAAAHPRD
T917KPSSTtPRLSRPhosphoSitePlus; HPRD; RegPhos
S605GISEDsHLESLphosphoELM
T712TQPAKtSTSKAHPRD
T76SQIEDtPSSKPHPRD
S696KELPPsPEKKTCDK1HPRD; phosphoELM; SysPTM
T287TKLDVtLAKDMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S742NKKPMsLASGLphosphoELM; RegPhos
T925LSRLAtNTSAPTubulin-bindingPhosphoSitePlus
S899MPSRPsTTPFIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T354TLLKEtERASPPhosphoSitePlus; HPRD; phosphoELM
T687GNDITtPPNKEHPRD
S253TDMAPsKETEMRegPhos
S1073QAKVGsLDNVGMARK_groupphosphoELM; RegPhos; SysPTM
T442ALSSEtEVALAHPRD
T722AKTQPtSLPKQHPRD
S1151QIQETHPRD; phosphoELM; SysPTM
S580DVPPLsETEATPhosphoSitePlus; HPRD; phosphoELM
S745PMSLAsGLVPAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T380ENKKEtERASPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T97EGSDTtGSPTEHPRD; RegPhos
S787PEKRAsPSKPACDK1HPRD; phosphoELM
S358ETERAsPIKMDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S793PSKPAsAPASRPhosphoSitePlus; HPRD; RegPhos
T521LGKDVtPPPETPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T627MISPEtITGTGphosphoELM; RegPhos; SysPTM
Y47VGKTDyIPLLDPhosphoSitePlus; HPRD; RegPhos
S1002KKVSYsHIQSKTubulin-bindingPhosphoSitePlus
S1151QIQETsIRegPhos; SysPTM
S431SSTEIsSAEKVCDC2RegPhos
S768PSILPsKDVKPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T878TTLSGtAPAAGPhosphoSitePlus; HPRD
T828SRSPStLLPKKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S624PTFMIsPETITRegPhos
S1073QAKVGsLDNVGMARK1HPRD; RegPhos; SysPTM
T804SGSKStQTVAKPhosphoSitePlus
S760RPAVAsARPSIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S868STSTSsMKKTTPhosphoSitePlus
S797ASAPAsRSGSKPhosphoSitePlus; HPRD
S643PAEEDsVLEKLRegPhos
T585SETEAtPVPIKPhosphoSitePlus; HPRD; phosphoELM
S202SPHSEsFVSPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S723KTQPTsLPKQPNBP1PhosphoSitePlus
S941RSKVGsTENIKphosphoELM
T960KVEKKtEAAATPhosphoSitePlus; HPRD
S1037ISKVSsKCGSKTubulin-bindingPhosphoSitePlus
S384ETERAsPIKMDPhosphoSitePlus; phosphoELM; RegPhos
S14ALTEPsPDIEGPhosphoSitePlus; HPRD
S1151QIQETsI____PhosphoSitePlus; SysPTM
S507LLKDMsPLSETPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T706TKPLAtTQPAKNBP1PhosphoSitePlus
T41DVVGEtVGKTDPhosphoSitePlus
S1041SSKCGsKANIKTubulin-bindingPhosphoSitePlus
S99SDTTGsPTEFLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1036DISKVsSKCGSTubulin-bindingPhosphoSitePlus
S914TSAKPsSTTPRPhosphoSitePlus; HPRD
T927RLATNtSAPDLHPRD
T28RDFIAtLEAEAPhosphoSitePlus
S787PEKRAsPSKPAPhosphoSitePlus; phosphoELM; RegPhos
Y1001SKKVSySHIQSTubulin-bindingPhosphoSitePlus
S197VEALNsPHSESPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S941RSKVGsTENIKTubulin-bindingPhosphoSitePlus
S280AKDMEsPTKLDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1000VSKKVsYSHIQHPRD; phosphoELM; RegPhos
T340VLPTEtEVAPAPhosphoSitePlus
S191VPQGWsVEALNHPRD
S822ASTGPsSRSPSPhosphoSitePlus; HPRD; phosphoELM
S937LKNVRsKVGSTHPRD
S827SSRSPsTLLPKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T925LSRLAtNTSAPHPRD; phosphoELM; RegPhos
T1150SQIQEtHPRD
Y110EEKMAyQEYPNPhosphoSitePlus
S696KELPPsPEKKTCDC2RegPhos; SysPTM
S68KKKPCsETSQIHPRD
S825GPSSRsPSTLLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S440KVALSsETEVAHPRD
T719TSKAKtQPTSLNBP1PhosphoSitePlus
S789KRASPsKPASAHPRD
S1000VSKKVsYSHIQTubulin-bindingPhosphoSitePlus
S329TETDVsSAKNVPhosphoSitePlus
S1073QAKVGsLDNVGHPRD; phosphoELM; RegPhos; SysPTM
T722AKTQPtSLPKQNBP1PhosphoSitePlus
S163ATADTsIFAGQHPRD
S1145AQTLDsQIQETPhosphoSitePlus
S636TGKKCsLPAEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T942SKVGStENIKHHPRD
S1037ISKVSsKCGSKHPRD; phosphoELM
Y1001SKKVSySHIQSHPRD; phosphoELM; RegPhos
S941RSKVGsTENIKMARK_groupphosphoELM; RegPhos
S937LKNVRsKVGSTTubulin-bindingPhosphoSitePlus
T571LANNVtPAKDVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S996KVQIVsKKVSYTubulin-bindingPhosphoSitePlus
S696KELPPsPEKKTCDC2(CDK1RegPhos; SysPTM
S863LSRPKsTSTSSPhosphoSitePlus
S823STGPSsRSPSTHPRD; phosphoELM
T714PAKTStSKAKTHPRD
S609DSHLEsLQDVGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T874MKKTTtLSGTAPhosphoSitePlus; RegPhos
S656RKPCNsQPSELRegPhos
T811TVAKTtTAAAVRegPhos
T11LADALtEPSPDHPRD
T324DVRWPtETDVSPhosphoSitePlus
T631GISEDSHLESLQDVGQSAAPTFMISPETITGTGKKSysPTM 2.0

Dephosphorylation site
MAP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379083P524LBIOMARTBreast Cancer21930507, 21930502
ENSP00000353375P524LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353375Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4418646787
ENSP00000353375Gastric CancerMetastasiscell lineUp2.317022644
ENSP00000353375Gastric CancerMetastasiscell lineUp2.317022644
ENSP00000353375Uterine CancerNormal vs. Cancercell lineUp39015838902

Hyperphosphorylation site
MAP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMAP4_HUMANkinase -> substrateRegPhos
CDK1_HUMANMAP4_HUMANkinase -> substrateRegPhos
MARK1_HUMANMAP4_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MAP4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008017microtubule bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0051012microtubule slidingIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0007052mitotic spindle organizationIEAbiological_process
GO:0051012microtubule slidingIEAbiological_process
GO:0005198structural molecule activityTASmolecular_function
GO:0051301cell divisionIMPbiological_process
GO:0051294establishment of spindle orientationIEAbiological_process
GO:0072686mitotic spindleIDAcellular_component
GO:0015631tubulin bindingIEAmolecular_function
GO:0005875microtubule associated complexTAScellular_component
GO:0051294establishment of spindle orientationIMPbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0007052mitotic spindle organizationIMPbiological_process
GO:0005874microtubuleIEAcellular_component