Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CUX1_HUMAN
Description:cut-like homeobox 1 [Source:HGNC Symbol;Acc:2557]
Location:chr7 q22.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1100PPASDsQPTTPPhosphoSitePlus
S1237YSQGAsPQPQHPhosphoSitePlus
S1233VGTEYsQGASPPhosphoSitePlus; HPRD
S391LEKNRsLQSENHPRD
S1216KRRHSsVSDSQPhosphoSitePlus
S1059SPAPEsPMSSSHPRD
S755PMPTVsSYPPLPhosphoSitePlus
S409SDLSGsARRKGHPRD
S585GLSQGsVSEILCUTPhosphoSitePlus
S768SLKKPsAAPEAPhosphoSitePlus
S749KLLSTsPMPTVHPRD
T739SQSDItILTPKPhosphoSitePlus
S1454APRRPsSLQSLPhosphoSitePlus; HPRD; phosphoELM
T1103SDSQPtTPLPLPhosphoSitePlus
T374SEGAGtQDAAKPhosphoSitePlus
S1458PSSLQsLFGLPPhosphoSitePlus
S1404PGPLPsPASATPhosphoSitePlus
S756MPTVSsYPPLAPhosphoSitePlus
S369MEFAPsEGAGTPhosphoSitePlus
S1237YSQGAsPQPQHCDK1HPRD; phosphoELM
S663TRIRAsETGSDPhosphoSitePlus; HPRD
Y351KGQADyEEVKKNPV_P10PhosphoSitePlus
T1104DSQPTtPLPLSPhosphoSitePlus
S734KQAPLsQSDITPhosphoSitePlus; HPRD
S1270QKPYPsPKTIECDK1HPRD; phosphoELM
S322RENSAsQISQLHPRD
T665IRASEtGSDEAPhosphoSitePlus; HPRD
S763PPLAIsLKKPSPhosphoSitePlus; HPRD
S1270QKPYPsPKTIEHomeoboxPhosphoSitePlus
Y1232SVGTEySQGASPhosphoSitePlus; HPRD
S363LNILKsMEFAPNPV_P10PhosphoSitePlus
S322RENSAsQISQLNPV_P10PhosphoSitePlus
S667ASETGsDEAIKPhosphoSitePlus; HPRD
Y889SAESPySQSSEPhosphoSitePlus
S868PRAERsQLQGPPhosphoSitePlus
T1380PPPSGtPGPDDPhosphoSitePlus
S452GTHQFsPAGLSHPRD; phosphoELM
T742DITILtPKLLSPhosphoSitePlus
S974KVLGLsQGSVSHPRD
S874QLQGPsSSEYWPhosphoSitePlus
S887WPSAEsPYSQSPhosphoSitePlus
T1352PGSADtEEPKSPhosphoSitePlus
S1054TSASCsPAPESHPRD
T1071SVKSLtELVQQHPRD
S467SSSLAsPSLPLPhosphoSitePlus; HPRD; phosphoELM
S1218RHSSVsDSQPCPhosphoSitePlus; HPRD
T1157TILGLtQGSVSCUTPhosphoSitePlus
S1357TEEPKsQGEAEPhosphoSitePlus; HPRD
S1215MKRRHsSVSDSPKA_groupphosphoELM
S1455PRRPSsLQSLFPhosphoSitePlus
S1215MKRRHsSVSDSPhosphoSitePlus
S1496LEKAAsREEPIPhosphoSitePlus; HPRD; phosphoELM
S1312EIQAGsQGQAGPhosphoSitePlus; HPRD
S59APLLKsFQGEIPhosphoSitePlus
T600PWNKLtVRGKECUTPhosphoSitePlus

Dephosphorylation site
CUX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000292535A769TCOSMICOvarian Cancer21720365
ENSP00000353401L652VTCGAOvarian Cancer21720365, 18772890
ENSP00000353401R672LTCGAOvarian Cancer21720365, 18772890
ENSP00000292535P1055TCOSMICOvarian Cancer21720365
ENSP00000292535D14VCOSMICOvarian Cancer21720365
ENSP00000353401D25VTCGAOvarian Cancer21720365, 18772890
ENSP00000292535R661LCOSMICOvarian Cancer21720365
ENSP00000292535E136KCOSMICPancreatic Cancer
ENSP00000353401A780TTCGAOvarian Cancer21720365, 18772890
ENSP00000292535L641VCOSMICOvarian Cancer21720365

Differential expressed protein
CUX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CUX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANCUX1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCUX1_HUMANkinase -> substrateRegPhos
CUX1_HUMANHBG1_HUMANTF -> target geneTRANSFAC
CUX1_HUMANCY24B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CUX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000139Golgi membraneIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0042491auditory receptor cell differentiationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0030674protein binding, bridgingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000301retrograde transport, vesicle recycling within GolIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component


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