Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VIME_HUMAN
Description:vimentin [Source:HGNC Symbol;Acc:12692]
Location:chr10 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S51PSTSRsLYASSPAK1RegPhos; SysPTM
S34SYVTTsTRTYSPKCaRegPhos; SysPTM
S39STRTYsLGSALPRKCAHPRD; SysPTM
S47SALRPsTSRSLPRKACAHPRD
S42TYSLGsALRPSPKCaRegPhos; SysPTM
S7STRSVsSSSYRPKACaRegPhos; SysPTM
Y117DRFANyIDKVRHPRD; phosphoELM; RegPhos
Y117DRFANyIDKVRDUF2464; TPR_MLP1_2; DUF3PhosphoSitePlus
S51PSTSRsLYASSPAK_groupphosphoELM; RegPhos; SysPTM
S39STRTYsLGSALPKACaRegPhos; SysPTM
S2RSVSHPRD
S7STRSVsSSSYRPKCaRegPhos; SysPTM
S51PSTSRsLYASSphosphoELM; SysPTM
S325RRQVQsLTCEVDUF3584; Filament; Reo_siPhosphoSitePlus; SysPTM
T37TTSTRtYSLGSFilament_head; DUF2464PhosphoSitePlus
Y291EAEEWyKSKFADUF3584; Filament; MyosinPhosphoSitePlus
S10SVSSSsYRRMFPKCaRegPhos
T32SRSYVtTSTRTFilament_head; DUF2464PhosphoSitePlus
S144KGQGKsRLGDLHPRD; phosphoELM; SysPTM
S65VYATRsSAVRLFilament_head; DUF2464PhosphoSitePlus
S26ASRPSsSRSYVPAK2HPRD; RegPhos; SysPTM
Y30SSSRSyVTTSTFilament_head; DUF2464PhosphoSitePlus; SysPTM
T20FGGPGtASRPSFilament_head; DUF2464PhosphoSitePlus
S47SALRPsTSRSLPKACaRegPhos
S42TYSLGsALRPSFilament_head; DUF2464PhosphoSitePlus; SysPTM
S39STRTYsLGSALMAPKAPK2phosphoELM; RegPhos; SysPTM
S56SLYASsPGGVYCDK1HPRD; phosphoELM; SysPTM
S26ASRPSsSRSYVPKC_groupRegPhos; SysPTM
S226ERKVEsLQEEIHPRD; phosphoELM; SysPTM
S10SVSSSsYRRMFPRKCAHPRD
S9RSVSSsSYRRMPKC_groupRegPhos
S73VRLRSsVPGVRPAK_groupphosphoELM; RegPhos; SysPTM
S56SLYASsPGGVYPAK_groupphosphoELM; SysPTM
T441THSKRtLLIKTPhosphoSitePlus
S83RLLQDsVDFSLCAMK2DHPRD; SysPTM
S42TYSLGsALRPSPKC_groupRegPhos; SysPTM
S65VYATRsSAVRLHPRD; phosphoELM
S29PSSSRsYVTTSHPRD; SysPTM
S66YATRSsAVRLRPKA_groupRegPhos
Y38TSTRTySLGSAFilament_head; DUF2464PhosphoSitePlus
S51PSTSRsLYASSPKA_groupRegPhos; SysPTM
S47SALRPsTSRSLFilament_head; DUF2464PhosphoSitePlus
S51PSTSRsLYASSPKC_groupRegPhos; SysPTM
S5_MSTRsVSSSSPhosphoSitePlus; SysPTM
S56SLYASsPGGVYFilament_head; DUF2464PhosphoSitePlus; SysPTM
S34SYVTTsTRTYSFilament_head; DUF2464PhosphoSitePlus; SysPTM
S409LEGEEsRISLPHPRD; phosphoELM
T327QVQSLtCEVDADUF3584; Filament; Reo_siPhosphoSitePlus
S56SLYASsPGGVYMAPKAPK2phosphoELM; RegPhos; SysPTM
S72AVRLRsSVPGVFilament_head; DUF2464PhosphoSitePlus
S66YATRSsAVRLRphosphoELM
T32SRSYVtTSTRTHPRD
Y383RHLREyQDLLNDUF3584; Filament; BaculoPhosphoSitePlus
S39STRTYsLGSALFilament_head; DUF2464PhosphoSitePlus; SysPTM
T426LNLREtNLDSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S73VRLRSsVPGVRAurora BphosphoELM; SysPTM
S7SSYRPRKCAHPRD; SysPTM
S39STRTYsLGSALPAK2HPRD; RegPhos; SysPTM
S5SSSSHPRD; phosphoELM; SysPTM
S47SALRPsTSRSLphosphoELM; RegPhos
T266SKPDLtAALRDHPRD
T35YVTTStRTYSLFilament_head; DUF2464PhosphoSitePlus
S7STRSVsSSSYRPKA_groupRegPhos; SysPTM
S26ASRPSsSRSYVPAK_groupphosphoELM; RegPhos; SysPTM
Y358VEAANyQDTIGDUF3584; Filament; BaculoPhosphoSitePlus
S25TASRPsSSRSYFilament_head; DUF2464PhosphoSitePlus; SysPTM
S205ENTLQsFRQDVHPRD
S56SLYASsPGGVYCDC2RegPhos; SysPTM
S9RSVSSsSYRRMFilament_headPhosphoSitePlus
S39STRTYsLGSALPKA_groupRegPhos; SysPTM
S39STRTYsLGSALphosphoELM; SysPTM
S7STRSVsSSSYRPKC_groupRegPhos; SysPTM
S144KGQGKsRLGDLDUF3584; FilamentPhosphoSitePlus; SysPTM
S34SYVTTsTRTYSPKC_groupRegPhos; SysPTM
S66YATRSsAVRLRPAK2HPRD; RegPhos
S56SLYASsPGGVYPAK1RegPhos; SysPTM
Y276DVRQQyESVAADUF3584; Filament; MyosinPhosphoSitePlus
S73VRLRSsVPGVRphosphoELM; RegPhos; SysPTM
S25TASRPsSSRSYPKCaRegPhos; SysPTM
S34SYVTTsTRTYSPRKCAHPRD; SysPTM
Y400IEIATyRKLLEHPRD
S9RSVSSsSYRRMPKCaRegPhos
S7STRSVsSSSYRFilament_headPhosphoSitePlus; SysPTM
T3___MStRSVSSPhosphoSitePlus
S419PLPNFsSLNLRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S87DSVDFsLADAIHPRD
S7SSYRphosphoELM; SysPTM
S72AVRLRsSVPGVROCK_groupphosphoELM; RegPhos
S39STRTYsLGSALPKC_groupRegPhos; SysPTM
S73VRLRSsVPGVRPAK2HPRD; RegPhos; SysPTM
S73VRLRSsVPGVRPAK1RegPhos; SysPTM
S66YATRSsAVRLRFilament_head; DUF2464PhosphoSitePlus
S25TASRPsSSRSYPRKCAHPRD; SysPTM
S56SLYASsPGGVYHPRD; phosphoELM; RegPhos; SysPTM
S412EESRIsLPLPNPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y11VSSSSyRRMFGFilament_headPhosphoSitePlus
S8TRSVSsSSYRRFilament_headPhosphoSitePlus
S72AVRLRsSVPGVphosphoELM; RegPhos
S39STRTYsLGSALCaMK2_groupRegPhos; SysPTM
T458QVINEtSQHHDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S205ENTLQsFRQDVDUF3584; Filament; MyosinPhosphoSitePlus
S409LEGEEsRISLPFilamentPhosphoSitePlus
T99TEFKNtRTNEKFilament_head; DUF2464; TPhosphoSitePlus
S42TYSLGsALRPSPRKCAHPRD; SysPTM
S34SYVTTsTRTYSphosphoELM; SysPTM
Y61SPGGVyATRSSFilament_head; DUF2464PhosphoSitePlus; SysPTM
S39STRTYsLGSALPKCaRegPhos; SysPTM
S299KFADLsEAANRHPRD; phosphoELM; SysPTM
S226ERKVEsLQEEIDUF3584; Filament; MyosinPhosphoSitePlus; SysPTM
Y400IEIATyRKLLEDUF3584; FilamentPhosphoSitePlus
S83RLLQDsVDFSLCaM-KII_alphaphosphoELM; SysPTM
S83RLLQDsVDFSLFilament_head; DUF2464; TPhosphoSitePlus; SysPTM
S39STRTYsLGSALPAK_groupphosphoELM; RegPhos; SysPTM
T48ALRPStSRSLYFilament_head; DUF2464PhosphoSitePlus
T436LPLVDtHSKRTPhosphoSitePlus; HPRD
S26ASRPSsSRSYVPKCaRegPhos; SysPTM
S83RLLQDsVDFSLCaMK2aRegPhos; SysPTM
S7SSYRPRKACAHPRD; SysPTM
Y61SPGGVyATRSSHPRD; phosphoELM; RegPhos; SysPTM
S438LVDTHsKRTLLPhosphoSitePlus; HPRD
S73VRLRSsVPGVRFilament_head; DUF2464PhosphoSitePlus; SysPTM
S55RSLYAsSPGGVHPRD; phosphoELM; RegPhos; SysPTM
Y38TSTRTySLGSAphosphoELM
S51PSTSRsLYASSPAK2HPRD; RegPhos; SysPTM
S66YATRSsAVRLRPKC_groupRegPhos
S73VRLRSsVPGVRAurB(Aurora BRegPhos; SysPTM
S66YATRSsAVRLRPAK_groupphosphoELM; RegPhos
T63GGVYAtRSSAVFilament_head; DUF2464PhosphoSitePlus
S51PSTSRsLYASSFilament_head; DUF2464PhosphoSitePlus; SysPTM
S261IDVDVsKPDLTDUF3584; Filament; MyosinPhosphoSitePlus
S214DVDNAsLARLDDUF3584; Filament; MyosinPhosphoSitePlus; SysPTM
S299KFADLsEAANRDUF3584; Filament; MyosinPhosphoSitePlus; SysPTM
S73VRLRSsVPGVRROCK_groupRegPhos; SysPTM
S56SLYASsPGGVYCDC2(CDK1RegPhos; SysPTM
T446TLLIKtVETRDPhosphoSitePlus; HPRD; RegPhos
S25TASRPsSSRSYphosphoELM; SysPTM
S55RSLYAsSPGGVFilament_head; DUF2464PhosphoSitePlus; SysPTM
S25TASRPsSSRSYPKACaRegPhos; SysPTM
T317AKQEStEYRRQDUF3584; Filament; Reo_siPhosphoSitePlus
S51PSTSRsLYASSMAPKAPK2phosphoELM; RegPhos; SysPTM
S325RRQVQsLTCEVHPRD; SysPTM
T33RSYVTtSTRTYHPRD; SysPTM
S29PSSSRsYVTTSFilament_head; DUF2464PhosphoSitePlus; SysPTM
S39STRTYsLGSALPRKACAHPRD; SysPTM
S214DVDNAsLARLDHPRD; phosphoELM; RegPhos; SysPTM
T99TEFKNtRTNEKHPRD
S261IDVDVsKPDLTHPRD
S83RLLQDsVDFSLMAPKAPK2phosphoELM; RegPhos; SysPTM
S42TYSLGsALRPSphosphoELM; SysPTM
T20FGGPGtASRPSHPRD
S5MSTRSvSSSSRegPhos; SysPTM
Y30SSSRSyVTTSTHPRD; SysPTM
T327QVQSLtCEVDAHPRD; phosphoELM
S26ASRPSsSRSYVFilament_head; DUF2464PhosphoSitePlus; SysPTM
S8TRSVSsSSYRRRegPhos
S27SRPSSsRSYVTFilament_head; DUF2464PhosphoSitePlus; SysPTM
Y150RLGDLyEEEMRDUF3584; Filament; MyosinPhosphoSitePlus
S339KGTNEsLERQMDUF3584; Filament; Reo_siPhosphoSitePlus
T48ALRPStSRSLYHPRD; phosphoELM
S25TASRPsSSRSYPKC_groupRegPhos; SysPTM
S83RLLQDsVDFSLphosphoELM; SysPTM
S22GPGTAsRPSSSHPRD; phosphoELM
S316QAKQEsTEYRRDUF3584; Filament; Reo_siPhosphoSitePlus
S22GPGTAsRPSSSFilament_head; DUF2464PhosphoSitePlus
S27SRPSSsRSYVTHPRD; phosphoELM; RegPhos; SysPTM
S459VINETsQHHDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S25TASRPsSSRSYPKA_groupRegPhos; SysPTM
S10SVSSSsYRRMFFilament_headPhosphoSitePlus
Y53TSRSLyASSPGFilament_head; DUF2464PhosphoSitePlus; SysPTM
S72AVRLRsSVPGVROCK1HPRD; phosphoELM; RegPhos
S9RSVSSsSYRRMPRKCAHPRD
Y53TSRSLyASSPGHPRD; phosphoELM; RegPhos; SysPTM
S420LPNFSsLNLREPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S10SVSSSsYRRMFPKC_groupRegPhos
S83RLLQDsVDFSLCaMK2_groupRegPhos; SysPTM
S430ETNLDsLPLVDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S25TASRPsSSRSYPRKACAHPRD; SysPTM
S83RLLQDsVDFSLCaMK2dRegPhos; SysPTM
S26ASRPSsSRSYVPRKCAHPRD; SysPTM

Dephosphorylation site
VIME_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000224237A232SCOSMICLung Cancer
ENSP00000446007E407KCOSMICOvarian Cancer21720365
ENSP00000446007E448KCOSMICHead and Neck Cancer21798893
ENSP00000224237E407KTCGAOvarian Cancer21720365, 18772890
ENSP00000224237E187*COSMICIntestines Cancer16959974
ENSP00000224237E407KCOSMICOvarian Cancer21720365
ENSP00000224237L433MCOSMICPancreatic Cancer
ENSP00000446007Q160KCOSMICOvarian Cancer21720365
ENSP00000446007E407KTCGAOvarian Cancer21720365, 18772890
ENSP00000446007E187*COSMICIntestines Cancer16959974
ENSP00000224237E448KCOSMICHead and Neck Cancer21798893
ENSP00000446007E103KCOSMICSkin Cancer21984974
ENSP00000224237E354DBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000224237E103KCOSMICSkin Cancer21984974
ENSP00000446007A232SCOSMICLung Cancer
ENSP00000446007L433MCOSMICPancreatic Cancer
ENSP00000224237Q324*BIOMARTBreast Cancer21930507, 21930502
ENSP00000224237E286*BIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000224237E187XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000224237Q160KCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000224237Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000224237Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.07718646787
ENSP00000224237Hepatocellular CarcinomaNormal vs. Cancercell lineUp1118646787
ENSP00000224237Pancreatic CancerNormal vs. CancertissueDown0.0516215274
ENSP00000224237Gastric CancerMetastasiscell lineUp2617022644
ENSP00000224237Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000224237colorectal cancerNormal vs. CancertissueDown0.5114997500
ENSP00000224237colorectal cancerNormal vs. CancertissueUp4.815924290
ENSP00000224237Esophageal CancerNormal vs. CancertissueDown0.1719142970
ENSP00000224237Esophageal CancerNormal vs. CancertissueDown0.319142970
ENSP00000224237Esophageal CancerNormal vs. CancertissueDown0.3119142970
ENSP00000224237Esophageal CancerNormal vs. CancertissueUp2.119142970
ENSP00000224237Esophageal CancerNormal vs. CancertissueUp2.219142970
ENSP00000224237Esophageal CancerNormal vs. CancertissueUp2.619142970
ENSP00000224237Oral CancerNormal vs. CancertissueUp316889763
ENSP00000224237Breast CancerTreatment (metastasis vs. metastasis-suppressed BRMS1)cell lineUp15168732
ENSP00000224237MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineUp3.317854218
ENSP00000224237Hepatocellular CarcinomaNormal vs. CancertissueUp2.511866469
ENSP00000224237hepatitis B virusNormal vs. CancertissueUp2.314654528
ENSP00000224237hepatitis C virusNormal vs. CancertissueUp2.314654528
ENSP00000224237Hepatocellular CarcinomaNormal vs. CancertissueUp2.314654528
ENSP00000224237Hepatocellular CarcinomaNormal vs. CancertissueUp18937283
ENSP00000224237Hepatocellular CarcinomaMetastasiscell lineUp1119016532
ENSP00000224237Small cell lung carcinomaTreatment (none vs. isogenic Doxorubicin-resistant)cell lineUp2.218654985
ENSP00000224237Lung CancerTreatment (none vs transfected with pc3.1-hPNAS5)cell lineUp19795389
ENSP00000224237Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineDown0.4316900703
ENSP00000224237Gastric CancerMetastasiscell lineUp2617022644
ENSP00000224237Gastric CancerNormal vs. CancertissueDown0.4619330469
ENSP00000224237Breast CancerMetastasiscell lineUp2.618582095
ENSP00000224237Breast CancerMetastasiscell lineDown0.7318582095
ENSP00000224237Breast CancerMetastasiscell lineUp1.518582095
ENSP00000224237Breast CancerTreatment (TNF-a-sensitive vs. TNF-a-resistant )cell lineUp2.119087274
ENSP00000224237Breast CancerNormal vs. CancertissueUp>1020005186
ENSP00000224237Breast CancerNormal vs. Cancercell lineDown0.2720052998
ENSP00000224237Breast CancerNormal vs. Cancercell lineDown0.2820052998
ENSP00000224237Breast CancerNormal vs. Cancercell lineUp2.620052998
ENSP00000224237Breast CancerNormal vs. Cancercell lineUp4.120052998
ENSP00000224237Breast CancerMetastasiscell lineUp1020052998
ENSP00000224237Breast CancerMetastasiscell lineUp1520052998
ENSP00000224237Breast CancerNormal vs. CancertissueUp1.520087651
ENSP00000224237Breast CancerNormal vs. CancertissueUp1.920087651
ENSP00000224237Breast CancerNormal vs. CancertissueUp220087651
ENSP00000224237Breast CancerNormal vs. CancertissueUp2.220087651
ENSP00000224237Breast CancerNormal vs. Cancercell lineDown0.0220198662
ENSP00000224237Breast CancerNormal vs. Cancercell lineUp3.820543960
ENSP00000224237breast ductal carcinomaNormal vs. CancertissueDown18564057
ENSP00000224237chronic lymphocytic leukemiaCancer vs. Cancer (agressive)tissueDown0.316083281
ENSP00000224237Renal CancerNormal vs. CancertissueUp2.4-31.012923786
ENSP00000224237Renal CancerNormal vs. CancertissueUp19164279
ENSP00000224237Renal CancerNormal vs. CancertissueUp2.619610612
ENSP00000224237MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.4418630942
ENSP00000224237MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.4718630942
ENSP00000224237MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.4818630942
ENSP00000224237MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.518630942
ENSP00000224237Pancreatic CancerNormal vs. CancertissueUp2.716230073
ENSP00000224237Gastric CancerNormal vs. Cancercell lineDown0.0920812763
ENSP00000224237Gastric CancerNormal vs. Cancercell lineDown0.0320812763
ENSP00000224237Biliary Tract CancerMetastasiscell lineUp3.819299076
ENSP00000224237Gastric CancerNormal vs. CancertissueDown0.1915761955
ENSP00000224237Gastric CancerNormal vs. CancertissueDown0.315761955
ENSP00000224237Uterine CancerNormal vs. Cancercell lineUp8.715838902
ENSP00000224237Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000224237Uterine CancerNormal vs. CancertissueDown0.119007971
ENSP00000224237Uterine CancerNormal vs. CancertissueDown19771267
ENSP00000224237Hepatocellular CarcinomaNormal vs. CancertissueUp2.211866469

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y117DUF2464; TPR_MLP1_2; DUF3584; FilamentLNDRFANyIDKVRFLcholangiocellular carcinoma21253578PhosphoSitePlus
Y38Filament_head; DUF2464VTTSTRTySLGSALRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANVIME_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MAPK2_HUMANVIME_HUMANkinase -> substrateRegPhos
PAK2_HUMANVIME_HUMANkinase -> substrateRegPhos
AURKB_HUMANVIME_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANVIME_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANVIME_HUMANkinase -> substrateRegPhos
KCC2D_HUMANVIME_HUMANkinase -> substrateHPRD
KPCA_HUMANVIME_HUMANkinase -> substrateHPRD
ROCK1_HUMANVIME_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045109intermediate filament organizationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0042995cell projectionIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0070307lens fiber cell developmentIEAbiological_process
GO:0005777peroxisomeIDAcellular_component
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0005200structural constituent of cytoskeletonIDAmolecular_function
GO:0060020Bergmann glial cell differentiationIEAbiological_process
GO:0005856cytoskeletonTAScellular_component
GO:0014002astrocyte developmentIEAbiological_process
GO:0045103intermediate filament-based processIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0005212structural constituent of eye lensIEAmolecular_function
GO:0006928cellular component movementTASbiological_process
GO:0030049muscle filament slidingTASbiological_process
GO:0005882intermediate filamentIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0097110scaffold protein bindingIPImolecular_function
GO:0031252cell leading edgeIEAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0005882intermediate filamentIEAcellular_component
GO:0005515protein bindingIPImolecular_function