Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LATS1_HUMAN
Description:LATS, large tumor suppressor, homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:6514]
Location:chr6 q25.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1079AFYEFtFRRFFphosphoELM; RegPhos
S278QTKRYsGNMEYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T490TVTAItPAPIQCDK1HPRD
S27NYTVSsRQMLQPhosphoSitePlus
T1079AFYEFtFRRFFMST2(STK3RegPhos
T255PPRGQtPPPRGPhosphoSitePlus
T967VINWQtSLHIPPkinasePhosphoSitePlus
S613KQITTsPITVRHPRD; phosphoELM; RegPhos; SysPTM
S244PPQVRsVTPPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T246QVRSVtPPPPPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y277SQTKRySGNMEPhosphoSitePlus
S872HPRQDsMDFSNPkinasePhosphoSitePlus
S674MRVGLsQDAQDCas_Cas6; YjcZPhosphoSitePlus
S464PVRSNsFNNPLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y1076PEHAFyEFTFRPkinase_CPhosphoSitePlus
S792GGDMMsLLIRMPkinasePhosphoSitePlus
S909RCLAHsLVGTPMST2(STK3RegPhos
S181QSWKGsKESLVPhosphoSitePlus
S613KQITTsPITVRCDC2RegPhos; SysPTM
T490TVTAItPAPIQPhosphoSitePlus
S909RCLAHsLVGTPphosphoELM; RegPhos
S1111GSEQQsDEDDQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S909RCLAHsLVGTPPkinasePhosphoSitePlus
T1079AFYEFtFRRFFPkinase_CPhosphoSitePlus
S26SNYTVsSRQMLPhosphoSitePlus
S674MRVGLsQDAQDHPRD; phosphoELM; RegPhos
Y23FPASNyTVSSRPhosphoSitePlus
S633ESRIQsYSPQACas_Cas6; YjcZPhosphoSitePlus
S613KQITTsPITVRCDK1HPRD; phosphoELM; SysPTM
T1060ENVNDtLNGWYPkinase_CPhosphoSitePlus
S633ESRIQsYSPQAphosphoELM; RegPhos
T261PPPRGtTPPPPHPRD
S334PIIMQsSSKFNHPRD
S336IMQSSsKFNFPPhosphoSitePlus
S1049PDKLWsDDNEEPkinase_CPhosphoSitePlus
S335IIMQSsSKFNFHPRD
Y283SGNMEyVISRIPhosphoSitePlus
S462NIPVRsNSFNNHPRD
Y143ISKMSyQDPRRPhosphoSitePlus
T612KKQITtSPITVCas_Cas6PhosphoSitePlus
S177VNRKQsWKGSKPhosphoSitePlus
S171GNVQQsVNRKQPhosphoSitePlus
T17QMRPKtFPASNPhosphoSitePlus
T611EKKQItTSPITHPRD
T490TVTAItPAPIQCDC2RegPhos
S613KQITTsPITVRCas_Cas6PhosphoSitePlus; SysPTM
T1012HPFFKtIDFSSPhosphoSitePlus
S864SKYYQsGDHPRPkinasePhosphoSitePlus

Dephosphorylation site
LATS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253339R1020TCOSMICOvarian Cancer21720365
ENSP00000253339V719IBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000437550L78fs*54COSMICOvarian Cancer21720365
ENSP00000253339T255NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000253339R252IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000253339P506RCOSMICOvarian Cancer21720365
ENSP00000253339G393ACOSMICLung Cancer20668451
ENSP00000253339R694CCOSMICOvarian Cancer21720365
ENSP00000253339R995CCOSMICBreast Cancer20668451
ENSP00000253339S394YCOSMICOvarian Cancer20668451
ENSP00000253339R502CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000253339M669IGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000253339P1028TCOSMICOvarian Cancer21720365
ENSP00000253339R806PGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000253339Q959HCOSMICBreast Cancer20668451
ENSP00000253339R806PHPINon-small cell lung carcinoma17344846
ENSP00000253339A748TCOSMICOvarian Cancer21720365

Differential expressed protein
LATS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LATS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LATS1_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANLATS1_HUMANkinase -> substrateRegPhos
LATS1_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANLATS1_HUMANkinase -> substrateRegPhos
STK3_HUMANLATS1_HUMANkinase -> substrateRegPhos
LATS1_HUMAN2AAA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
LATS1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0000819sister chromatid segregationIDAbiological_process
GO:0005815microtubule organizing centerIEAcellular_component
GO:0043254regulation of protein complex assemblyIMPbiological_process
GO:0045736negative regulation of cyclin-dependent protein kiIDAbiological_process
GO:0035329hippo signaling cascadeIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIMPbiological_process
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034613cellular protein localizationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0051220cytoplasmic sequestering of proteinIMPbiological_process
GO:0000922spindle poleIDAcellular_component
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0009755hormone-mediated signaling pathwayISSbiological_process
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0030833regulation of actin filament polymerizationIDAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0035329hippo signaling cascadeIEAbiological_process


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