Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SYN3_HUMAN
Description:synapsin III [Source:HGNC Symbol;Acc:11496]
Location:chr22 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S552STSDTsQRGTPPhosphoSitePlus
S455PQRSGsPSQQRPhosphoSitePlus
S473PLSPQsGSPQQPhosphoSitePlus
S470GQQPLsPQSGSMAPK3phosphoELM
S453PQPQRsGSPSQPhosphoSitePlus
S470GQQPLsPQSGSCDC2(CDK1RegPhos
S470GQQPLsPQSGSPhosphoSitePlus; HPRD; RegPhos
S470GQQPLsPQSGSErk1(MAPK3RegPhos
S484QRSPGsPQLSRPhosphoSitePlus; RegPhos
S475SPQSGsPQQQRPhosphoSitePlus
S457RSGSPsQQRLSPhosphoSitePlus
S470GQQPLsPQSGSCDK1phosphoELM
T32RPDSStSSPASSynapsin_NPhosphoSitePlus
S462SQQRLsPQGQQPhosphoSitePlus; RegPhos

Dephosphorylation site
SYN3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351614V246LCOSMICMelanoma21499247
ENSP00000351614S447CBIOMARTBreast Cancer21930507, 21930502
ENSP00000351614A66TCOSMICHead and Neck Cancer21798893
ENSP00000351614S462FCOSMICSkin Cancer21984974

Differential expressed protein
SYN3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SYN3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANSYN3_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANSYN3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANSYN3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
SYN3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030054cell junctionIEAcellular_component
GO:0007269neurotransmitter secretionIEAbiological_process
GO:0008021synaptic vesicleIEAcellular_component
GO:0030672synaptic vesicle membraneIEAcellular_component
GO:0045202synapseIEAcellular_component
GO:0008021synaptic vesicleTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function


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