Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BIRC5_HUMAN
Description:baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:593]
Location:chr17 q25.3
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T117KIAKEtNNKKKPhosphoSitePlus
T117KIAKEtNNKKKAurora BphosphoELM
T34EGCACtPERMABIRPhosphoSitePlus; SysPTM
T21DHRIStFKNWPBIRPhosphoSitePlus
T34EGCACtPERMACDC2(CDK1RegPhos; SysPTM
S20KDHRIsTFKNWBIRPhosphoSitePlus
T117KIAKEtNNKKKAurB(Aurora BRegPhos
T34EGCACtPERMACDK1HPRD; phosphoELM; SysPTM
T34EGCACtPERMACDC2RegPhos; SysPTM
T48FIHCPtENEPDBIRPhosphoSitePlus

Dephosphorylation site
BIRC5_HUMAN do not have dephosphorylation site.

Mutation site
BIRC5_HUMAN do not have mutation site.

Differential expressed protein
BIRC5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BIRC5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AURKB_HUMANBIRC5_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANBIRC5_HUMANkinase -> substrateHPRD; RegPhos
LEF1_HUMANBIRC5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05210Colorectal cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032133chromosome passenger complexIPIcellular_component
GO:0051303establishment of chromosome localizationIMPbiological_process
GO:0004869cysteine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0008017microtubule bindingTASmolecular_function
GO:0005814centrioleIDAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0000228nuclear chromosomeIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0005874microtubuleIEAcellular_component
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005819spindleIEAcellular_component
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0000777condensed chromosome kinetochoreIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000775chromosome, centromeric regionIDAcellular_component
GO:0007059chromosome segregationIEAbiological_process
GO:0043027cysteine-type endopeptidase inhibitor activity invIMPmolecular_function
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0031503protein complex localizationIMPbiological_process
GO:0000910cytokinesisIMPbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0007067mitosisTASbiological_process
GO:0015631tubulin bindingIDAmolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0051087chaperone bindingIPImolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0008536Ran GTPase bindingIPImolecular_function
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0030496midbodyIDAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0050897cobalt ion bindingNASmolecular_function
GO:0005881cytoplasmic microtubuleIDAcellular_component
GO:0031536positive regulation of exit from mitosisIMPbiological_process
GO:0031021interphase microtubule organizing centerIDAcellular_component
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0031577spindle checkpointIMPbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0048037cofactor bindingIDAmolecular_function
GO:0042981regulation of apoptotic processIMPbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0043154negative regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0005515protein bindingIPImolecular_function


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