Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	ZYX_HUMAN
Description:	zyxin [Source:HGNC Symbol;Acc:13200]
Location:	chr7 q34
Node attribute:	substrate

Phosphorylation site

Position	PhosphoPeptide	Source
S150	DLEIDsLSSLL	PhosphoSitePlus; HPRD
S169	FKARVsSGYVP	PhosphoSitePlus; HPRD; phosphoELM
S290	PGGSGsQPNQK	PhosphoSitePlus; HPRD; phosphoELM
S259	GPPASsPAPAP	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
T270	KFSPVtPKFTP	PhosphoSitePlus; HPRD; phosphoELM
T306	ALSAGtGSPQP	PhosphoSitePlus; HPRD
S143	REKVSsIDLEI	PhosphoSitePlus; HPRD
T274	VTPKFtPVASK	PhosphoSitePlus; HPRD; phosphoELM
S281	VASKFsPGAPG	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
T179	PPPVAtPFSSK	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
S15	ISVSVsAPAFY	PhosphoSitePlus
S288	GAPGGsGSQPN	PhosphoSitePlus; HPRD; phosphoELM
Y20	SAPAFyAPQKK	PhosphoSitePlus
S170	KARVSsGYVPP	PhosphoSitePlus; HPRD; phosphoELM
T315	QPPSFtYAQQR	PhosphoSitePlus; HPRD; phosphoELM
Y172	RVSSGyVPPPV	PhosphoSitePlus; HPRD
S142	PREKVsSIDLE	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
T352	APGPLtLKEVE	HPRD
S313	SPQPPsFTYAQ	PhosphoSitePlus; HPRD; phosphoELM
Y316	PPSFTyAQQRE	PhosphoSitePlus
S258	RGPPAsSPAPA	PhosphoSitePlus; HPRD; phosphoELM
S303	HPEALsAGTGS	PhosphoSitePlus; HPRD; phosphoELM
S308	SAGTGsPQPPS	PhosphoSitePlus; HPRD; phosphoELM
S344	QNQVRsPGAPG	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
S267	PAPKFsPVTPK	PhosphoSitePlus; HPRD; phosphoELM; SysPTM
S278	FTPVAsKFSPG	PhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site

ZYX_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000324422	Q217E	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000324422	K265T	BIOMART	Pancreatic Cancer	21930507, 21930502

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000324422	Prostate Cancer	Metastasis	tissue	Down	0.45	18553995
ENSP00000324422	Pancreatic Cancer	Normal vs. Cancer	tissue	Up	3.1	16230073

Hyperphosphorylation site

ZYX_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
FGFR4_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
LATS1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
RAF1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TYK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KPCZ_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
EPHA3_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
NEK3_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
PRKY_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
ACK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
GRK5_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
UHMK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK6_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KKCC1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
GSK3B_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
BMP2K_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KC1G2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
ULK3_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
WNK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
FYN_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TNI3K_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
AAPK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
NEK9_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
MAPK5_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
SIK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
WEE1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
STK4_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KPCI_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TGFR2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KPCA_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
FGR_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
DYR1B_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
LCK_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TESK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
PIM2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CLK4_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
FGFR2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
MK10_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CHK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
FAK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
DMPK_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
AURKB_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
TRIB3_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
ARAF_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
BTK_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
NEK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KSYK_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
BUB1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
FAK1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
MP2K7_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A4_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
DYRK4_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK18_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CLK2_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
KS6A1_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK7_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)

Function Annotation

KEGG Pathway

ZYX_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007165	signal transduction	TAS	biological_process
GO:0001725	stress fiber	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005887	integral to plasma membrane	TAS	cellular_component
GO:0019048	virus-host interaction	IEA	biological_process
GO:0007155	cell adhesion	IEA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0005913	cell-cell adherens junction	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005925	focal adhesion	IDA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network