| UniProt/SwissProt ID: | RIR2_HUMAN |
| Description: | ribonucleotide reductase M2 [Source:HGNC Symbol;Acc:10452] |
| Location: | chr2 p25.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T12 | PLAPItDPQQL | PhosphoSitePlus | |
| S20 | QQLQLsPLKGL | CDC2(CDK1 | RegPhos; SysPTM |
| S20 | QQLQLsPLKGL | CDK1 | HPRD; phosphoELM; SysPTM |
| T40 | PALSGtRVLAS | PhosphoSitePlus | |
| T318 | IGMNCtLMKQY | Ribonuc_red_sm | PhosphoSitePlus |
| S45 | TRVLAsKTARR | PhosphoSitePlus | |
| S20 | QQLQLsPLKGL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S26 | PLKGLsLVDKE | PhosphoSitePlus | |
| S38 | TPPALsGTRVL | PhosphoSitePlus | |
| S263 | SNELIsRDEGL | Ribonuc_red_sm | PhosphoSitePlus |
| S377 | MGVMSsPTENS | PhosphoSitePlus | |
| S20 | QQLQLsPLKGL | CDC2 | RegPhos; SysPTM |
| Y221 | DKEATyGERVV | Ribonuc_red_sm | PhosphoSitePlus |
| T33 | VDKENtPPALS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y369 | KRVGEyQRMGV | PhosphoSitePlus | |
| T47 | VLASKtARRIF | PhosphoSitePlus | |
| Dephosphorylation site |
| RIR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000302955 | D138H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000302955 | I324T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| RIR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RIR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | RIR2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | RIR2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00240 | Pyrimidine metabolism |
| hsa00480 | Glutathione metabolism |
| hsa01100 | Metabolic pathways |
| hsa04115 | p53 signaling pathway |
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000083 | regulation of transcription involved in G1/S phase | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0051259 | protein oligomerization | IEA | biological_process |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0009263 | deoxyribonucleotide biosynthetic process | IEA | biological_process |
| GO:0016491 | oxidoreductase activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004748 | ribonucleoside-diphosphate reductase activity, thi | ISS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0009262 | deoxyribonucleotide metabolic process | IEA | biological_process |
| GO:0055086 | nucleobase-containing small molecule metabolic pro | TAS | biological_process |
| GO:0051290 | protein heterotetramerization | IEA | biological_process |
| GO:0009186 | deoxyribonucleoside diphosphate metabolic process | IEA | biological_process |
| GO:0046914 | transition metal ion binding | IEA | molecular_function |
| GO:0005971 | ribonucleoside-diphosphate reductase complex | IEA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0015949 | nucleobase-containing small molecule interconversi | TAS | biological_process |
| GO:0004748 | ribonucleoside-diphosphate reductase activity, thi | IEA | molecular_function |
| GO:0005737 | cytoplasm | NAS | cellular_component |
| GO:0009263 | deoxyribonucleotide biosynthetic process | ISS | biological_process |
| GO:0006260 | DNA replication | NAS | biological_process |