Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CHK1_HUMAN
Description:checkpoint kinase 1 [Source:HGNC Symbol;Acc:1925]
Location:chr11 q24.2
Node attribute:PPI(source); substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S317VKYSSsQPEPRPhosphoSitePlus; phosphoELM; SysPTM
S280RPRVTsGGVSEAKT1(PKB) RegPhos
S280RPRVTsGGVSEAKT1HPRD; RegPhos
S345QGISFsQPTCPATRHPRD; phosphoELM; RegPhos
S280RPRVTsGGVSEPhosphoSitePlus; phosphoELM
S345QGISFsQPTCPPhosphoSitePlus; phosphoELM
S305FSPVNsASSEEPhosphoSitePlus; HPRD
T362SQLLGtPGSSQPhosphoSitePlus
S280RPRVTsGGVSEPKB_groupphosphoELM
S343LVQGIsFSQPTPhosphoSitePlus
T330LSLWDtSPSYIPhosphoSitePlus; HPRD
T348SFSQPtCPDHMPhosphoSitePlus
S365LGTPGsSQNPWPhosphoSitePlus
S291SPSGFsKHIQSPhosphoSitePlus
S301SNLDFsPVNSAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S284TSGGVsESPSGPhosphoSitePlus; HPRD; phosphoELM
S333WDTSPsYIDKLPhosphoSitePlus
S366GTPGSsQNPWQPhosphoSitePlus
S301SNLDFsPVNSACDK1phosphoELM; SysPTM
S467LIDIVsSQKIWPhosphoSitePlus
S307PVNSAsSEENVHPRD
S468IDIVSsQKIWLPhosphoSitePlus; HPRD; SysPTM
S296SKHIQsNLDFSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S357HMLLNsQLLGTPhosphoSitePlus
S308VNSASsEENVKPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S286GGVSEsPSGFSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S315ENVKYsSSQPEPhosphoSitePlus
S331SLWDTsPSYIDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S345QGISFsQPTCPATMphosphoELM; RegPhos
S280RPRVTsGGVSEAKT_groupRegPhos
T279KRPRVtSGGVSPhosphoSitePlus; HPRD
S316NVKYSsSQPEPPhosphoSitePlus
S288VSESPsGFSKHPhosphoSitePlus; HPRD
S389LDADKsYQCLKPhosphoSitePlus
S317VKYSSsQPEPRATRHPRD; phosphoELM; RegPhos; SysPTM
S317VKYSSsQPEPRATMphosphoELM; RegPhos; SysPTM

Dephosphorylation site
CHK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000388648E320KBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000388648R160HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000432890R160HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000412504R160HTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000435371R160HTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
CHK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S280AKRPRVTsGGVSESPbreast cancer17418864PhosphoSitePlus
S345LVQGISFsQPTCPDHRIDDLE syndrome17940005PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CHK1_HUMANMCM4_HUMANkinase -> substrateRegPhos
CHK1_HUMANMDM4_HUMANkinase -> substrateHPRD
CHK1_HUMANRAD51_HUMANkinase -> substrateHPRD; RegPhos
CHK1_HUMANCLSPN_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCHK1_HUMANkinase -> substrateRegPhos
MAPK5_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANCHK1_HUMANkinase -> substrateRegPhos
MK13_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
CHK1_HUMANP73_HUMANkinase -> substrateRegPhos
CHK1_HUMANMPIP1_HUMANkinase -> substrateRegPhos
ILK_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
IRAK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANCHK1_HUMANkinase -> substrateHPRD; RegPhos
TESK2_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
CHK1_HUMANCDK1_HUMANkinase -> substrateKEGG
CHK1_HUMANMPIP3_HUMANkinase -> substrateHPRD; RegPhos
CDK3_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
CHK1_HUMANP53_HUMANkinase -> substrateRegPhos
CHK1_HUMANTLK1_HUMANkinase -> substrateHPRD; RegPhos
ATR_HUMANCHK1_HUMANkinase -> substrateRegPhos
NUAK1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
M3K8_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
CHK1_HUMANESPL1_HUMANotherKEGG
P53_HUMANCHK1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection
hsa04110Cell cycle
hsa05203Viral carcinogenesis
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035402histone kinase activity (H3-T11 specific)IEAmolecular_function
GO:0000785chromatinIEAcellular_component
GO:0006260DNA replicationTASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0071313cellular response to caffeineIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0000794condensed nuclear chromosomeIDAcellular_component
GO:0000077DNA damage checkpointIDAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045839negative regulation of mitosisIDAbiological_process
GO:2000615regulation of histone H3-K9 acetylationIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0033261regulation of S phaseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035407histone H3-T11 phosphorylationIDAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000086G2/M transition of mitotic cell cycleIEAbiological_process
GO:0031572G2/M transition DNA damage checkpointIEAbiological_process
GO:0005657replication forkIEAcellular_component
GO:0090399replicative senescenceNASbiological_process
GO:0010767regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0006975DNA damage induced protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010569regulation of double-strand break repair via homolIDAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0048096chromatin-mediated maintenance of transcriptionIEAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0046602regulation of mitotic centrosome separationIDAbiological_process
GO:0000077DNA damage checkpointIEAbiological_process


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