Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RCC1_HUMAN
Description:regulator of chromosome condensation 1 [Source:HGNC Symbol;Acc:1913]
Location:chr1 p35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2____MsPKRIAPhosphoSitePlus
S2MSPKRiACDC2RegPhos
T274YHQLGtPGTESRCC1PhosphoSitePlus
S406VLSVSsGGQHTRCC1PhosphoSitePlus
S422VVLSVsSGGQHHPRD
S11IAKRRsPPADAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S311TVCMDsEGKAYPhosphoSitePlus
T428SGGQHtVLLVKHPRD
Y89KSGQVySFGCNRCC1PhosphoSitePlus
S405VVLSVsSGGQHRCC1PhosphoSitePlus
S437VLSVSsGGQHTHPRD
T32HRSHStEPGLVPhosphoSitePlus
S2KRIACDK1HPRD
S29KVSHRsHSTEPPhosphoSitePlus
T411SGGQHtVLLVKRCC1PhosphoSitePlus
S423VLSVSsGGQHTHPRD
S104LGRDTsVEGSERCC1PhosphoSitePlus
S20DAIPKsKKVKVPhosphoSitePlus
S406VLSVSsGGQHTHPRD; phosphoELM; RegPhos
S387DEDAWsPVEMMRCC1PhosphoSitePlus
T442SGGQHtVLLVKHPRD
S26KKVKVsHRSHSPhosphoSitePlus
S405VVLSVsSGGQHHPRD; phosphoELM; RegPhos
S90SGQVYsFGCNDRCC1PhosphoSitePlus
S436VVLSVsSGGQHHPRD
S403NRVVLsVSSGGRCC1PhosphoSitePlus
T411SGGQHtVLLVKHPRD; phosphoELM; RegPhos
S403NRVVLsVSSGGphosphoELM; RegPhos
T306GGQHHtVCMDSRCC1PhosphoSitePlus

Dephosphorylation site
RCC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362937Y354DTCGAOvarian Cancer21720365, 18772890
ENSP00000362939Y323DCOSMICOvarian Cancer21720365
ENSP00000362938Y323DCOSMICOvarian Cancer21720365
ENSP00000381931Y323DCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000381931Gastric CancerMetastasiscell lineUp1.917022644
ENSP00000381931Gastric CancerMetastasiscell lineUp1.917022644

Hyperphosphorylation site
RCC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRCC1_HUMANkinase -> substrateRegPhos
CDK1_HUMANRCC1_HUMANkinase -> substrateHPRD; RegPhos
MK06_HUMANRCC1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANRCC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RCC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007090regulation of S phase of mitotic cell cycleIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0051225spindle assemblyIMPbiological_process
GO:0007088regulation of mitosisIDAbiological_process
GO:0031492nucleosomal DNA bindingIDAmolecular_function
GO:0042393histone bindingIDAmolecular_function
GO:0005087Ran guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0031965nuclear membraneIDAcellular_component
GO:0051301cell divisionIEAbiological_process
GO:0007052mitotic spindle organizationIDAbiological_process
GO:0007067mitosisIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0000794condensed nuclear chromosomeIDAcellular_component
GO:0000790nuclear chromatinIDAcellular_component
GO:0005087Ran guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007059chromosome segregationIMPbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0005737cytoplasmIDAcellular_component


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