Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RB_HUMAN
Description:retinoblastoma 1 [Source:HGNC Symbol;Acc:9884]
Location:chr13 q14.2
Node attribute:PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S780RPPTLsPIPHIP30279(Cyclin D2RegPhos
Y813PLKSPyKISEGHPRD; phosphoELM
T252NGSPRtPRRGQCDC2RegPhos
T5RKTACDK4HPRD
S807GNIYIsPLKSPCDK2HPRD
S773ILQYAsTRPPTRb_CPhosphoSitePlus
Y325RYEEIyLKNKDPhosphoSitePlus
T583DREGPtDHLESPhosphoSitePlus
T252NGSPRtPRRGQPhosphoSitePlus; phosphoELM
S567AWLSDsPLFDLRB_APhosphoSitePlus
T823GLPTPtKMTPRHPRD; phosphoELM
S788PHIPRsPYKFPCDK4HPRD; RegPhos
S624TTRVNsTANAEPhosphoSitePlus
S811ISPLKsPYKISCDC2RegPhos
T373VIPPHtPVRTVCDK_groupphosphoELM; RegPhos
T826TPTKMtPRSRIphosphoELM; RegPhos
T821SEGLPtPTKMTRb_CPhosphoSitePlus
Y813PLKSPyKISEGRb_CPhosphoSitePlus
T356FETQRtPRKSNCDK4HPRD; RegPhos
T821SEGLPtPTKMTphosphoELM
S842ESFGTsEKFQKRb_CPhosphoSitePlus
S829KMTPRsRILVSRb_CPhosphoSitePlus
T625TRVNStANAETPhosphoSitePlus
S834SRILVsIGESFRb_CPhosphoSitePlus
T356FETQRtPRKSNPhosphoSitePlus; phosphoELM
T373VIPPHtPVRTVCDC2RegPhos
T774LQYAStRPPTLRb_CPhosphoSitePlus
S37DPEQDsGPEDLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S795YKFPSsPLRIPHPRD
Y805PGGNIyISPLKRb_CPhosphoSitePlus
S249IPINGsPRTPRCDC2RegPhos
S230YFIKLsPPMLLPhosphoSitePlus
T823GLPTPtKMTPRRb_CPhosphoSitePlus
S780RPPTLsPIPHIRb_CPhosphoSitePlus
S895HLPGEsKFQQKRb_CPhosphoSitePlus
T252NGSPRtPRRGQCDK1HPRD
S855QMVCNsDRVLKHPRD; phosphoELM; SysPTM
S811ISPLKsPYKISCDK1HPRD
S811ISPLKsPYKISCDK2HPRD
S163LFALFsKLERTDUF3452PhosphoSitePlus
T821SEGLPtPTKMTCDK2HPRD; RegPhos
T353IDSFEtQRTPRPhosphoSitePlus; HPRD; phosphoELM
S811ISPLKsPYKISphosphoELM
T826TPTKMtPRSRICDK4HPRD; RegPhos
T140LKEIDtSTKVDDUF3452PhosphoSitePlus
T373VIPPHtPVRTVCDK1HPRD
S811ISPLKsPYKISRb_CPhosphoSitePlus
S780RPPTLsPIPHICDK4HPRD; RegPhos
S807GNIYIsPLKSPCDK1HPRD
S780RPPTLsPIPHICCND2HPRD
T345DKTLQtDSIDSPhosphoSitePlus
S882FDIEGsDEADGRb_CPhosphoSitePlus
S612LSPVRsPKKKGCDK2HPRD; RegPhos
T826TPTKMtPRSRIRb_CPhosphoSitePlus
S588TDHLEsACPLNPhosphoSitePlus
T252NGSPRtPRRGQCDK_groupphosphoELM; RegPhos
S360RTPRKsNLDEEPhosphoSitePlus
S795YKFPSsPLRIPRb_CPhosphoSitePlus
S855QMVCNsDRVLKRb_CPhosphoSitePlus; SysPTM
S249IPINGsPRTPRCDK1HPRD
T5_MPPKtPRKTAPhosphoSitePlus
T841GESFGtSEKFQRb_CPhosphoSitePlus
T241KEPYKtAVIPIPhosphoSitePlus
S838VSIGEsFGTSERb_CPhosphoSitePlus
S249IPINGsPRTPRCDK_groupphosphoELM; RegPhos
Y790IPRSPyKFPSSRb_CPhosphoSitePlus
T601LQNNHtAADMYPhosphoSitePlus; HPRD
T373VIPPHtPVRTVRB_APhosphoSitePlus
T373VIPPHtPVRTVphosphoELM
S807GNIYIsPLKSPRb_CPhosphoSitePlus
S794PYKFPsSPLRIRb_CPhosphoSitePlus
Y321NLSKRyEEIYLPhosphoSitePlus
S618PKKKGsTTRVNPhosphoSitePlus
S807GNIYIsPLKSPphosphoELM
S811ISPLKsPYKISCDK_groupphosphoELM; RegPhos
S612LSPVRsPKKKGPhosphoSitePlus; phosphoELM
S347TLQTDsIDSFEPhosphoSitePlus
S788PHIPRsPYKFPRb_CPhosphoSitePlus
S230YFIKLsPPMLLCDK2HPRD; RegPhos
T905KLAEMtSTRTRRb_CPhosphoSitePlus
S807GNIYIsPLKSPCDC2RegPhos
S149VDNAMsRLLKKDUF3452PhosphoSitePlus
S807GNIYIsPLKSPCDK_groupphosphoELM; RegPhos
Y606TAADMyLSPVRPhosphoSitePlus; HPRD; phosphoELM
S816SPYKIsEGLPTRb_CPhosphoSitePlus
S350TDSIDsFETQRPhosphoSitePlus
S608ADMYLsPVRSPPhosphoSitePlus
S249IPINGsPRTPRPhosphoSitePlus; phosphoELM
T778STRPPtLSPIPRb_CPhosphoSitePlus
S780RPPTLsPIPHIHPRD
S795YKFPSsPLRIPCDK4HPRD; RegPhos
T5MPPKTpRKTACDK4RegPhos
S567AWLSDsPLFDLCDK2HPRD; RegPhos
S919QKMNDsMDTSNRb_CPhosphoSitePlus
S608ADMYLsPVRSPCDK2HPRD; RegPhos

Dephosphorylation site
RB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000267163R320*TCGAOvarian Cancer21720365, 18772890
ENSP00000267163R763TTCGAOvarian Cancer21720365, 18772890
ENSP00000267163R358GHPIHead and Neck Cancer8776589
ENSP00000267163E72QHPIHead and Neck Cancer8605116
ENSP00000267163R500GHPIHead and Neck Cancer11524739
ENSP00000267163K530RHPIHead and Neck Cancer7704558
ENSP00000267163H673PHPIHead and Neck Cancer
ENSP00000267163A635PHPIHead and Neck Cancer7795591
ENSP00000267163E440*Ding2008, BIOMARTLung Cancer18428421, 18948947, 21930507, 21930502
ENSP00000267163Q395*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163R150SBIOMARTGastric Cancer21930507, 21930502
ENSP00000267163N803KHPIHead and Neck Cancer8605116
ENSP00000267163L657PHPIHead and Neck Cancer8776589
ENSP00000267163L662PHPIHead and Neck Cancer10671068
ENSP00000267163R661WTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163W563*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000267163Q685PHPIHead and Neck Cancer7795591
ENSP00000267163R787*TCGAOvarian Cancer21720365, 18772890
ENSP00000267163Q702*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163R661WOMIM, HPIHead and Neck Cancer1352883 10486322, 1352883 7927327 8776589 9311732 18677112 15643604
ENSP00000267163G310EHPIHead and Neck Cancer9973307
ENSP00000267163Q217*Ding2008Neoplasms by Histologic Type18428421, 18948947
ENSP00000267163V654EHPIHead and Neck Cancer7795591
ENSP00000267163S567LOMIM, HPIHead and Neck Cancer2594029, 2594029 10671068
ENSP00000267163H549YHPIHead and Neck Cancer8605116
ENSP00000267163M457RHPIHead and Neck Cancer8346255
ENSP00000267163E137DHPIHead and Neck Cancer9311732
ENSP00000267163R621PTCGAOvarian Cancer21720365, 18772890
ENSP00000267163R251*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163K447QHPIHead and Neck Cancer9140452
ENSP00000267163Y659FTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163A264VTCGAOvarian Cancer21720365, 18772890
ENSP00000267163R698WBIOMARTBrain Cancer21930507, 21930502
ENSP00000267163Q217*Ding2008, BIOMARTLung Cancer18428421, 18948947, 21930507, 21930502
ENSP00000267163Y728CBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000267163K616EHPIHead and Neck Cancer11524739
ENSP00000267163C712ROMIM, HPIHead and Neck Cancer10486322, 10671068
ENSP00000267163I185THPIHead and Neck Cancer7795591
ENSP00000267163Y424*TCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000267163C706YHPIHead and Neck Cancer
ENSP00000267163R556*BIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000267163E79*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000267163E440*Ding2008Neoplasms by Histologic Type18428421, 18948947

Differential expressed protein
RB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S807Rb_CPGGNIYIsPLKSPYKmelanoma skin cancer15502804PhosphoSitePlus
S811Rb_CIYISPLKsPYKISEGmelanoma skin cancer15502804PhosphoSitePlus
S795Rb_CSPYKFPSsPLRIPGGmelanoma skin cancer15502804PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRB_HUMANkinase -> substrateRegPhos
CCND2_HUMANRB_HUMANkinase -> substrateHPRD
CDK1_HUMANRB_HUMANkinase -> substrateRegPhos
CDK4_HUMANRB_HUMANkinase -> substrateRegPhos; NetPath
CDK2_HUMANRB_HUMANkinase -> substrateRegPhos; NetPath
CDK6_HUMANRB_HUMANkinase -> substrateNetPath
MDM2_HUMANRB_HUMANotherKEGG
P53_HUMANRB_HUMANTF -> target geneTRANSFAC
E2F1_HUMANRB_HUMANTF -> target geneTRANSFAC
ATF2_HUMANRB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05218Melanoma
hsa05166HTLV-I infection
hsa05203Viral carcinogenesis
hsa05212Pancreatic cancer
hsa05223Non-small cell lung cancer
hsa05214Glioma
hsa05169Epstein-Barr virus infection
hsa05215Prostate cancer
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa04110Cell cycle
hsa05219Bladder cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0035189Rb-E2F complexTAScellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0030308negative regulation of cell growthTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007090regulation of S phase of mitotic cell cycleIEAbiological_process
GO:0001047core promoter bindingIDAmolecular_function
GO:0043550regulation of lipid kinase activityIDAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiTASbiological_process
GO:0003713transcription coactivator activityNASmolecular_function
GO:0007265Ras protein signal transductionIEPbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0042551neuron maturationIEAbiological_process
GO:0045445myoblast differentiationIMPbiological_process
GO:0048565digestive tract developmentIEAbiological_process
GO:0043353enucleate erythrocyte differentiationIEAbiological_process
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0031575mitotic cell cycle G1/S transition checkpointTASbiological_process
GO:0007346regulation of mitotic cell cycleIMPbiological_process
GO:0045842positive regulation of mitotic metaphase/anaphase IMPbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0035189Rb-E2F complexIEAcellular_component
GO:0051402neuron apoptotic processIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0016605PML bodyIDAcellular_component
GO:0071922regulation of cohesin localization to chromatinIMPbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0016514SWI/SNF complexTAScellular_component
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006469negative regulation of protein kinase activityIPIbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0071930negative regulation of transcription involved in GIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0071459protein localization to chromosome, centromeric reIMPbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0000785chromatinTAScellular_component
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0031134sister chromatid biorientationIMPbiological_process
GO:0051219phosphoprotein bindingIPImolecular_function
GO:0007050cell cycle arrestIEAbiological_process
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0034088maintenance of mitotic sister chromatid cohesionIMPbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0005819spindleIEAcellular_component
GO:0000279M phaseNASbiological_process
GO:0045651positive regulation of macrophage differentiationIEAbiological_process
GO:0090230regulation of centromere complex assemblyTASbiological_process
GO:0051318G1 phaseTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008134transcription factor bindingIPImolecular_function
GO:0048667cell morphogenesis involved in neuron differentiatIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0007346regulation of mitotic cell cycleIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0007050cell cycle arrestTASbiological_process
GO:0006338chromatin remodelingTASbiological_process
GO:0001102RNA polymerase II activating transcription factor IEAmolecular_function
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0045786negative regulation of cell cycleIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0019900kinase bindingIDAmolecular_function
GO:0045749negative regulation of S phase of mitotic cell cycTASbiological_process