| UniProt/SwissProt ID: | TOPK_HUMAN |
| Description: | PDZ binding kinase [Source:HGNC Symbol;Acc:18282] |
| Location: | chr8 p21.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S57 | SPRGLsHSPWA | HPRD; SysPTM | |
| S59 | RGLSHsPWAVK | HPRD; phosphoELM; RegPhos; SysPTM | |
| T200 | ENMTVtDPEAC | RegPhos | |
| T9 | ISNFKtPSKLS | PhosphoSitePlus | |
| S32 | INIPAsPFMQK | PhosphoSitePlus; HPRD; phosphoELM | |
| S76 | NDHYRsVYQKR | Pkinase | PhosphoSitePlus |
| T9 | ISNFKtPSKLS | CDC2 | RegPhos |
| S23 | KSVLCsTPTIN | PhosphoSitePlus; HPRD; phosphoELM | |
| T9 | ISNFKtPSKLS | CCNB1 | HPRD |
| S310 | PKDRPsAAHIV | HPRD | |
| T9 | ISNFKtPSKLS | P14635(Cyclin B1 | RegPhos |
| T9 | ISNFKtPSKLS | CDC2(CDK1 | RegPhos |
| Y47 | TGVNVyLMKRS | Pkinase | PhosphoSitePlus |
| S264 | KTFDEsDFDDE | HPRD | |
| Y100 | PNIVGyRAFTE | Pkinase | PhosphoSitePlus |
| T26 | LCSTPtINIPA | PhosphoSitePlus; HPRD | |
| T24 | SVLCStPTINI | PhosphoSitePlus; HPRD; phosphoELM | |
| Y78 | HYRSVyQKRLM | Pkinase | PhosphoSitePlus |
| T9 | ISNFKtPSKLS | CDK1 | HPRD; phosphoELM |
| S59 | RGLSHsPWAVK | Pkinase | PhosphoSitePlus; SysPTM |
| Y74 | ICNDHyRSVYQ | Pkinase | PhosphoSitePlus |
| S19 | SEKKKsVLCST | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| TOPK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| TOPK_HUMAN do not have mutation site. |
| Differential expressed protein |
| TOPK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TOPK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TOPK_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TOPK_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TOPK_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | TOPK_HUMAN | kinase -> substrate | RegPhos |
| TOPK_HUMAN | 2AAB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK1_HUMAN | TOPK_HUMAN | kinase -> substrate | HPRD; RegPhos |
| CCNB1_HUMAN | TOPK_HUMAN | kinase -> substrate | HPRD |
| TOPK_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TOPK_HUMAN | GA45A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TOPK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007067 | mitosis | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0005575 | cellular_component | ND | cellular_component |