Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TOPK_HUMAN
Description:PDZ binding kinase [Source:HGNC Symbol;Acc:18282]
Location:chr8 p21.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S57SPRGLsHSPWAHPRD; SysPTM
S59RGLSHsPWAVKHPRD; phosphoELM; RegPhos; SysPTM
T200ENMTVtDPEACRegPhos
T9ISNFKtPSKLSPhosphoSitePlus
S32INIPAsPFMQKPhosphoSitePlus; HPRD; phosphoELM
S76NDHYRsVYQKRPkinasePhosphoSitePlus
T9ISNFKtPSKLSCDC2RegPhos
S23KSVLCsTPTINPhosphoSitePlus; HPRD; phosphoELM
T9ISNFKtPSKLSCCNB1HPRD
S310PKDRPsAAHIVHPRD
T9ISNFKtPSKLSP14635(Cyclin B1RegPhos
T9ISNFKtPSKLSCDC2(CDK1RegPhos
Y47TGVNVyLMKRSPkinasePhosphoSitePlus
S264KTFDEsDFDDEHPRD
Y100PNIVGyRAFTEPkinasePhosphoSitePlus
T26LCSTPtINIPAPhosphoSitePlus; HPRD
T24SVLCStPTINIPhosphoSitePlus; HPRD; phosphoELM
Y78HYRSVyQKRLMPkinasePhosphoSitePlus
T9ISNFKtPSKLSCDK1HPRD; phosphoELM
S59RGLSHsPWAVKPkinasePhosphoSitePlus; SysPTM
Y74ICNDHyRSVYQPkinasePhosphoSitePlus
S19SEKKKsVLCSTPhosphoSitePlus; HPRD

Dephosphorylation site
TOPK_HUMAN do not have dephosphorylation site.

Mutation site
TOPK_HUMAN do not have mutation site.

Differential expressed protein
TOPK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TOPK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TOPK_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANTOPK_HUMANkinase -> substrateRegPhos
TOPK_HUMAN2AAB_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANTOPK_HUMANkinase -> substrateHPRD; RegPhos
CCNB1_HUMANTOPK_HUMANkinase -> substrateHPRD
TOPK_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TOPK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0007067mitosisNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingNASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationNASbiological_process
GO:0005575cellular_componentNDcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23