Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NPM_HUMAN
Description:nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Source:HGNC Symbol;Acc:7910]
Location:chr5 q35.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y67AEAMNyEGSPINucleoplasminPhosphoSitePlus
S10MDMDMsPLRPQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T237EKTPKtPKGPSCDK1HPRD; phosphoELM; SysPTM
S4MEDSMdMDMRegPhos
S227SKGQEsFKKQEHPRD; RegPhos
T199KSIRDtPAKNACDK2HPRD; RegPhos; SysPTM
S139KLLSIsGKRSANucleoplasmin; DUF4366; TPhosphoSitePlus
S4MEDSMdMDMPLK1RegPhos
S217KDSKPsSTPRSHPRD
T199KSIRDtPAKNACDC2(CDK1RegPhos; SysPTM
S88VQPTVsLGGFEHPRD; phosphoELM
S243PKGPSsVEDIKTFIIF_alpha; Nop14PhosphoSitePlus
T234KKQEKtPKTPKHPRD; phosphoELM; RegPhos
Y17LRPQNyLFGCEHPRD
S106RLKCGsGPVHIHPRD; RegPhos
S227SKGQEsFKKQEPKC_groupphosphoELM; RegPhos
T234KKQEKtPKTPKCDK1HPRD; phosphoELM
S217KDSKPsSTPRSTFIIF_alpha; Nop14PhosphoSitePlus
S137DVKLLsISGKRHPRD; phosphoELM; RegPhos; SysPTM
S70MNYEGsPIKVTNucleoplasminPhosphoSitePlus; SysPTM
S254AKMQAsIEKHPRD; SysPTM
T219SKPSStPRSKGCDC2RegPhos
T250NCFRMtDQEAIHPRD
T237EKTPKtPKGPSTFIIF_alpha; Nop14PhosphoSitePlus; SysPTM
S242TPKGPsSVEDIHPRD
S112GPVHIsGQHLVHPRD
S254AKMQAsIEKGGHPRD; phosphoELM; RegPhos; SysPTM
T78KVTLAtLKMSVHPRD; phosphoELM
S222SSTPRsKGQESTFIIF_alpha; Nop14PhosphoSitePlus
S214PKGPSsVEDIKHPRD
S231IEKGGsLPKVEHPRD
T237EKTPKtPKGPSHPRD; phosphoELM; RegPhos; SysPTM
S254AKMQAsIEKGGTFIIF_alpha; Nop14PhosphoSitePlus; SysPTM
S260IEKGGsLPKVETFIIF_alphaPhosphoSitePlus; SysPTM
S139KLLSIsGKRSAHPRD; phosphoELM
T219SKPSStPRSKGTFIIF_alpha; Nop14PhosphoSitePlus
T219SKPSStPRSKGHPRD; phosphoELM; RegPhos
S218DSKPSsTPRSKHPRD
T199KSIRDtPAKNACDK1phosphoELM; SysPTM
S88VQPTVsLGGFENucleoplasminPhosphoSitePlus
S222SSTPRsKGQESHPRD
S4DMDMHPRD; phosphoELM
T75SPIKVtLATLKNucleoplasminPhosphoSitePlus
S143ISGKRsAPGGGNucleoplasmin; DUF4366; TPhosphoSitePlus
S112GPVHIsGQHLVNucleoplasmin; DUF4366; TPhosphoSitePlus
T95GGFEItPPVVLNucleoplasmin; DUF4366PhosphoSitePlus
S293WQWRKsL____PhosphoSitePlus
T75SPIKVtLATLKHPRD; phosphoELM; RegPhos
S70MNYEGsPIKVTHPRD; phosphoELM; RegPhos; SysPTM
S214QNGKDsKPSSTTFIIF_alpha; Nop14PhosphoSitePlus
S4__MEDsMDMDMPhosphoSitePlus
S43NEHQLsLRTVSHPRD
S243PKGPSsVEDIKHPRD; phosphoELM
T46QLSLRtVSLGAHPRD
S106RLKCGsGPVHINucleoplasmin; DUF4366PhosphoSitePlus
S4DMDMPLK1HPRD; phosphoELM
S218DSKPSsTPRSKTFIIF_alpha; Nop14PhosphoSitePlus
Y29KADKDyHFKVDNucleoplasminPhosphoSitePlus
S225AKMQAsIEKGGHPRD
S137DVKLLsISGKRNucleoplasmin; DUF4366; TPhosphoSitePlus; SysPTM
S227SKGQEsFKKQETFIIF_alpha; Nop14PhosphoSitePlus
T199KSIRDtPAKNATFIIF_alpha; Nop14PhosphoSitePlus; SysPTM
S198KKGQEsFKKQEHPRD
T234KKQEKtPKTPKCDC2(CDK1RegPhos
T237EKTPKtPKGPSCDC2RegPhos; SysPTM
T208EKTPKtPKGPSCDK1HPRD
T279NCFRMtDQEAITFIIF_alphaPhosphoSitePlus
T78KVTLAtLKMSVNucleoplasminPhosphoSitePlus
Y67AEAMNyEGSPIHPRD; phosphoELM
S195APVKKsIRDTPHPRD
S195APVKKsIRDTPNucleoplasmin; TFIIF_alphPhosphoSitePlus
T234KKQEKtPKTPKTFIIF_alpha; Nop14PhosphoSitePlus
Y17LRPQNyLFGCENucleoplasminPhosphoSitePlus
S213TPKGPsSVEDIHPRD
T237EKTPKtPKGPSCDC2(CDK1RegPhos; SysPTM
T95GGFEItPPVVLHPRD; phosphoELM; RegPhos
T279NCFRMtDQEAIHPRD; phosphoELM
S125EEDAEsEDEEENucleoplasmin; DUF4366; TPhosphoSitePlus; SysPTM
T234KKQEKtPKTPKCDC2RegPhos
S242TPKGPsSVEDITFIIF_alpha; Nop14PhosphoSitePlus
S125EEDAEsEDEEEHPRD; phosphoELM; RegPhos; SysPTM
T205KKQEKtPKTPKCDK1HPRD
S260IEKGGsLPKVEHPRD; phosphoELM; RegPhos; SysPTM
T219SKPSStPRSKGCDK1HPRD
T199KSIRDtPAKNAHPRD; phosphoELM; RegPhos; SysPTM

Dephosphorylation site
NPM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296930S293PCOSMICLymphoma20979630
ENSP00000296930W288*COSMICLymphoma19593743
ENSP00000296930W290GCOSMICLymphoma20979630
ENSP00000428755W290GCOSMICLymphoma20979630
ENSP00000296930G69DCOSMICMelanoma
ENSP00000428755S293PCOSMICLymphoma20979630
ENSP00000428755G69DCOSMICMelanoma
ENSP00000428755W288*COSMICLymphoma19593743

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000296930Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000296930Hepatocellular CarcinomaNormal vs. CancertissueUp317627933
ENSP00000296930Prostate CancerMetastasiscell lineUp1.718232632
ENSP00000296930Prostate CancerMetastasistissueUp318553995
ENSP00000296930Oral Premalignant LesionsNormal vs. CancertissueUp1.219072117
ENSP00000296930Oral Premalignant LesionsNormal vs. CancertissueDown0.9619072117
ENSP00000296930Oral Premalignant LesionsNormal vs. CancertissueUp1.619072117
ENSP00000296930Oral Premalignant LesionsNormal vs. CancertissueUp1.719072117
ENSP00000296930Breast CancerNormal vs. Cancercell lineUp214997480
ENSP00000296930Breast CancerTreatment (none vs. multidrug resistant)cell lineDown0.5916540677
ENSP00000296930Breast CancerMetastasistissueUp1.218416831
ENSP00000296930Hepatocellular CarcinomaNormal vs. CancertissueUp11866469
ENSP00000296930hepatitis B virusNormal vs. CancertissueUp6.914654528
ENSP00000296930hepatitis C virusNormal vs. CancertissueUp6.914654528
ENSP00000296930Hepatocellular CarcinomaNormal vs. CancertissueUp6.914654528
ENSP00000296930hepatitis C virusNormal vs. CancertissueUp3.316097030
ENSP00000296930hepatitis B virusNormal vs. Cancercell lineUp3.919187611
ENSP00000296930Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineDown15684709
ENSP00000296930Non-small cell lung carcinomaMetastasiscell lineDown0.2917418446
ENSP00000296930Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp1120804217
ENSP00000296930Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineUp1.718253933
ENSP00000296930Breast CancerMetastasiscell lineDown0.6418582095
ENSP00000296930Breast CancerMetastasiscell lineDown0.6518582095
ENSP00000296930Breast CancerMetastasiscell lineDown0.7418582095
ENSP00000296930Breast CancerNormal vs. CancertissueUp20560667
ENSP00000296930Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000296930Gastric CancerTreatment (none vs. hexamethylene bisacetamide (HMBA) treatment)cell lineDown20440860
ENSP00000296930Hepatocellular CarcinomaNormal vs. CancertissueUp11866469

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T199TFIIF_alpha; Nop14VKKSIRDtPAKNAQKKaposi's sarcoma20333249PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDK2_HUMANNPM_HUMANkinase -> substrateHPRD; RegPhos
DYRK4_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
KPCL_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANNPM_HUMANkinase -> substrateHPRD; RegPhos
CDK1_HUMANNPM_HUMANkinase -> substrateRegPhos
BMX_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANNPM_HUMANkinase -> substrateRegPhos
KPCD_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NPM_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051059NF-kappaB bindingISSmolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0008285negative regulation of cell proliferationISSbiological_process
GO:0008104protein localizationIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0060699regulation of endoribonuclease activityIDAbiological_process
GO:0005634nucleusISScellular_component
GO:0006334nucleosome assemblyIDAbiological_process
GO:0046599regulation of centriole replicationIMPbiological_process
GO:0051082unfolded protein bindingISSmolecular_function
GO:0006886intracellular protein transportTASbiological_process
GO:0007165signal transductionNASbiological_process
GO:0042393histone bindingIDAmolecular_function
GO:0043024ribosomal small subunit bindingIDAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0006281DNA repairIDAbiological_process
GO:0043023ribosomal large subunit bindingIDAmolecular_function
GO:0006913nucleocytoplasmic transportTASbiological_process
GO:0042255ribosome assemblyTASbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0005737cytoplasmISScellular_component
GO:0007098centrosome cycleISSbiological_process
GO:0005813centrosomeISScellular_component
GO:0007569cell agingISSbiological_process
GO:0046982protein heterodimerization activityIMPmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0006950response to stressIMPbiological_process
GO:0031616spindle pole centrosomeIDAcellular_component
GO:0010826negative regulation of centrosome duplicationIMPbiological_process
GO:0030957Tat protein bindingIDAmolecular_function
GO:0032071regulation of endodeoxyribonuclease activityIDAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0034080CENP-A containing nucleosome assembly at centromerTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0043066negative regulation of apoptotic processNASbiological_process
GO:0051259protein oligomerizationIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23